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Author Details

Alejandro V Villarino
University of Miami Miller School of Medicine
2001
65
40
PMIDPaper TitleJournal TitlePublished Year
37402563Multivalent tyrosine kinase inhibition promotes T cell recruitment to immune-desert gastric cancers by restricting epithelial-mesenchymal transition via tumour-intrinsic IFN-γ signalling.Gut2023
37559725T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis.Front Immunol2023
37732296Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma.Mol Ther Oncolytics2023
36946782Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer.Cancer Discov2023
37443284Transcription factor EGR2 controls homing and pathogenicity of T<sub>H</sub>17 cells in the central nervous system.Nat Immunol2023
37009861Transcriptional programing of T cell metabolism by STAT family transcription factors.Eur J Immunol2023
36427325A central role for STAT5 in the transcriptional programing of T helper cell metabolism.Sci Immunol2022
35446623MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection.Proc Natl Acad Sci U S A2022
34507993IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca<sup>2+</sup> through the noncanonical STAT3 pathway.Proc Natl Acad Sci U S A2021
34644563PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8<sup>+</sup> T cells at the expense of central memory.Cell Rep2021
32332067IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis.Sci Immunol2020
33028646Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair-deficient tumors.Cold Spring Harb Mol Case Stud2020
33326784Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells.Cell Rep2020
32634740T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria.iScience2020
32589961SnapShot: Jak-STAT Signaling II.Cell2020
33010223Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells.Immunity2020
31519812Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-T<sub>FH</sub> cells.Sci Immunol2019
31377117The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1.Mol Cell2019
29187589STAT5B: A Differential Regulator of the Life and Death of CD4<sup>+</sup> Effector Memory T Cells.J Immunol2018
29358051Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.Cell2018
28930659Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.Immunity2017
28498100Extraordinary effects of unnatural pairings.Elife2017
28323260Mechanisms and consequences of Jak-STAT signaling in the immune system.Nat Immunol2017
29282366JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.Nat Rev Drug Discov2017
29104284JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.Nat Rev Drug Discov2017
29202461IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.JCI Insight2017
28916644Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells.J Exp Med2017
28530713BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.Nat Immunol2017
26999798Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.Elife2016
28713870IL-10 induces a STAT3-dependent autoregulatory loop in T<sub>H</sub>2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.Sci Immunol2016
26446995An autoregulatory enhancer controls mammary-specific STAT5 functions.Nucleic Acids Res2016
25587654The JAK-STAT pathway: impact on human disease and therapeutic intervention.Annu Rev Med2015
26482142IL-27 shakes up the establishment of ectopic lymphoid structures.J Exp Med2015
25992861Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.Immunity2015
25689436IL-1 watches the watchmen.Nat Immunol2015
25527793Mechanisms of Jak/STAT signaling in immunity and disease.J Immunol2015
24632714A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.Blood2014
25217959An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.Nat Genet2014
25123275Transcriptional and epigenetic networks of helper T and innate lymphoid cells.Immunol Rev2014
23382546T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.J Exp Med2013
23746840Posttranscriptional control of T cell effector function by aerobic glycolysis.Cell2013
22684943IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens.Eur J Immunol2012
23209316Distinct requirements for T-bet in gut innate lymphoid cells.J Exp Med2012
21236706Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells.Immunity2011
19949064Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells.J Immunol2010
20974984STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms.J Immunol2010
20921406Duration of antigen receptor signaling determines T-cell tolerance or activation.Proc Natl Acad Sci U S A2010
18375937IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD.Int Immunol2008
17227909Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.J Exp Med2007
16365415IL-27 limits IL-2 production during Th1 differentiation.J Immunol2006
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Collaborators

John J O'Shea
National Institute of Arthritis, National Institutes of Health
Co-authored papers 32
Yuka Kanno
Co-authored papers 15
Han-Yu Shih
National Eye Institute, National Institutes of Health
Co-authored papers 6
Golnaz Vahedi
Co-authored papers 5
Fred P Davis
Howard Hughes Medical Institute
Co-authored papers 4
Massimo Gadina
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Co-authored papers 4
Kan Jiang
Co-authored papers 3
Yasmine Belkaid
National Institute of Allergy and Infectious Diseases
Co-authored papers 3
Cristina M Tato
Institute of Immunity, Stanford University School of Medicine
Co-authored papers 3
Nicolas Bouladoux
National Institute of Allergy and Infectious Diseases
Co-authored papers 2
Michael T McManus
Co-authored papers 2
Chen Yao
University of Texas Southwestern Medical Center
Co-authored papers 2
Garry P Nolan
Stanford University School of Medicine
Co-authored papers 1
Allyson L Byrd
Genentech Inc.
Co-authored papers 1
Vinodh N Rajapakse
Co-authored papers 1
Jahangheer Shaik
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
Jana Vandrovcova
UCL Queen Square Institute of Neurology
Co-authored papers 1
Jesse H Arbuckle
National Institute of Allergy and Infectious Diseases
Co-authored papers 1
Stephan C Sch??rer
Institute for Data Science and Computing, University of Miami
Co-authored papers 1
Loyal A Goff
Johns Hopkins University School of Medicine
Co-authored papers 1
David L Wiest
Fox Chase Cancer Center
Co-authored papers 1
Howard A Young
Center for Cancer Research, National Cancer Institute
Co-authored papers 1
Daniel J Cua
Merck & Co., Inc.
Co-authored papers 1
Chaochen Wang
Co-authored papers 1
Lionel Feigenbaum
Science Applications International Corporation/Frederick
Co-authored papers 1
Leonard B Maggi
Washington University School of Medicine
Co-authored papers 1
Jens G Lohr
Co-authored papers 1
Tak W Mak
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
Jonathan L Linehan
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
David E Levy
NYU Grossman School of Medicine
Co-authored papers 1
Release 1.2