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Author Details

Jeffrey F DiBerto
University of North Carolina at Chapel Hill
2013
37
20
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37090610A proximity proteomics pipeline with improved reproducibility and throughput.bioRxiv2024
36411392Insights into distinct signaling profiles of the µOR activated by diverse agonists.Nat Chem Biol2023
37808655A suite of engineered mice for interrogating psychedelic drug actions.bioRxiv2023
37555591De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework.J Chem Inf Model2023
36973264Structural insights into the human niacin receptor HCA2-G<sub>i</sub> signalling complex.Nat Commun2023
37162828De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep Learning Framework.bioRxiv2023
36787384Catalytic site mutations confer multiple states of G protein activation.Sci Signal2023
36638794Structures of the entire human opioid receptor family.Cell2023
36906681Molecular mechanism of biased signaling at the kappa opioid receptor.Nat Commun2023
36450356Structure-based design of bitopic ligands for the µ-opioid receptor.Nature2023
34797943Molecular insights into psychedelic drug action.J Neurochem2022
35836068TRUPATH: An Open-Source Biosensor Platform for Interrogating the GPCR Transducerome.Methods Mol Biol2022
35403009Agonist and antagonist TRUPATH assays for G protein-coupled receptors.STAR Protoc2022
35999277Serotonin modulates an inhibitory input to the central amygdala from the ventral periaqueductal gray.Neuropsychopharmacology2022
36171289Bespoke library docking for 5-HT<sub>2A</sub> receptor agonists with antidepressant activity.Nature2022
34505767A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.J Med Chem2021
34411534The cranial windows of perception.Neuron2021
34789874Structure, function and pharmacology of human itch GPCRs.Nature2021
34426574The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice.Nat Commun2021
31494142Chronic intermittent ethanol exposure dysregulates a GABAergic microcircuit in the bed nucleus of the stria terminalis.Neuropharmacology2020
31744862Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice.J Neurosci2020
32946782Structure of a Hallucinogen-Activated Gq-Coupled 5-HT<sub>2A</sub> Serotonin Receptor.Cell2020
32632286Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.Nat Neurosci2020
32367019TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome.Nat Chem Biol2020
31140276Sex-Dependent Modulation of Anxiety and Fear by 5-HT<sub>1A</sub> Receptors in the Bed Nucleus of the Stria Terminalis.ACS Chem Neurosci2019
27956747Acute engagement of G<sub>q</sub>-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior.Mol Psychiatry2018
30076467GABA neurons of the ventral periaqueductal gray area modulate behaviors associated with anxiety and conditioned fear.Brain Struct Funct2018
30868140DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs <i>in Vitro</i> and <i>in Vivo</i>.ACS Pharmacol Transl Sci2018
27624846Sex differences in the behavioral sequelae of chronic ethanol exposure.Alcohol2017
27036650Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating.Behav Brain Res2016
27556938Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala.Nature2016
25320048The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo.J Pharmacol Exp Ther2015
25881115Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.Neuropsychopharmacology2015
25937170A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.Neuron2015
24917543Different contributions of dopamine D1 and D2 receptor activity to alcohol potentiation of brain stimulation reward in C57BL/6J and DBA/2J mice.J Pharmacol Exp Ther2014
24810108Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J mice.Psychopharmacology (Berl)2014
24205018Changes in sensitivity of reward and motor behavior to dopaminergic, glutamatergic, and cholinergic drugs in a mouse model of fragile X syndrome.PLoS One2013
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Collaborators

Bryan L Roth
UNC Chapel Hill School of Medicine
Co-authored papers 21
Xi-Ping Huang
University of North Carolina School of Medicine
Co-authored papers 7
Jian Jin
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 5
Georgios Skiniotis
Stanford University School of Medicine
Co-authored papers 4
Michael J Robertson
Stanford University School of Medicine
Co-authored papers 4
Kuglae Kim
University of North Carolina School of Medicine
Co-authored papers 4
Brian E Krumm
University of North Carolina School of Medicine
Co-authored papers 4
Kate L White
Lawrence Berkeley National Laboratory
Co-authored papers 3
Alpay B Seven
Stanford University School of Medicine
Co-authored papers 3
Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Bryan L Roth
UNC School of Medicine
Co-authored papers 2
David E Nichols
Eshelman School of Pharmacy, University of North Carolina
Co-authored papers 2
Carl-Mikael Suomivuori
Stanford University School of Medicine
Co-authored papers 1
Jiewei Xu
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Yasmin L Hurd
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Mark von Zastrow
University of California san francisco
Co-authored papers 1
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 1
Ruth H??ttenhain
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Nadia Arang
Moores Cancer Center, University of California San Diego
Co-authored papers 1
Jorge Silvio Gutkind
Moores Cancer Center, University of California San Diego
Co-authored papers 1
Gye Won Han
Bridge Institute, University of Southern California
Co-authored papers 1
Petr Popov
Skolkovo Institute of Science and Technology
Co-authored papers 1
Ying-Xian Pan
Co-authored papers 1
Can Cao
University of North Carolina School of Medicine
Co-authored papers 1
John J Irwin
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Cynthia M Bulik
Karolinska Institutet
Co-authored papers 1
Aaron Marley
University of California san francisco
Co-authored papers 1
Joel Karpiak
Department of Pharmaceutical Sciences, University of California San Francisco
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Suwen Zhao
ShanghaiTech University, China iHuman Institute
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Release 1.2