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Author Details

Yasuto Kido
Shionogi & Co.
1999
22
16
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34974334Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse.Drug Metab Pharmacokinet2022
34413161Identification of Food-Derived Isoflavone Sulfates as Inhibition Markers for Intestinal Breast Cancer Resistance Proteins.Drug Metab Dispos2021
33765486Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction.Eur J Med Chem2021
31549838Discovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.J Med Chem2019
31657130Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden.ChemMedChem2019
29733614Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.J Med Chem2018
29775538Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.J Med Chem2018
27878880Highly Conformationally Restricted Cyclopropane Tethers with Three-Dimensional Structural Diversity Drastically Enhance the Cell Permeability of Cyclic Peptides.Chemistry2017
25801152A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.Bioorg Med Chem2015
25625617Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.J Med Chem2015
23241029Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.J Med Chem2013
23634759Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).J Med Chem2013
24900510Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.ACS Med Chem Lett2012
21599003Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.J Med Chem2011
17965255Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa.Reproduction2007
15618650Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes.Drug Metab Pharmacokinet2002
11739607Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier.J Neurochem2001
11341366Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood-brain barrier.J Pharm Pharmacol2001
10714609Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies.Pharm Res2000
11328664Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine.J Drug Target2000
10991972Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.J Pharmacol Exp Ther2000
10579682Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1.J Pharm Pharmacol1999
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Collaborators

Yusuke Nakamura
Japanese Foundation for Cancer Research
Co-authored papers 4
Kathleen M Giacomini
University of California San Francisco
Co-authored papers 2
Kari M Morrissey
Amunix Pharmaceuticals
Co-authored papers 1
Arik A Zur
Schools of Pharmacy and Medicine, University of California san francisco
Co-authored papers 1
Alan Kosaka
Roche Palo Alto LLC
Co-authored papers 1
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Yong Huang
Collegeville
Co-authored papers 1
Xuexiang Zhang
Baruch S. Blumberg Institute
Co-authored papers 1
Matthias Wittwer
F. Hoffmann-La Roche Ltd.
Co-authored papers 1
P??r Matsson
University of Gothenburg
Co-authored papers 1
Natalia Khuri
Stanford University
Co-authored papers 1
Release 1.2