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Author Details

Ernesto Guccione
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
2001
106
44
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36732506G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma.Nat Commun2023
37537299WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma.Nat Cancer2023
35584893Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications.Gut2023
37156770Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis.Nat Commun2023
37095322PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma.Nat Cell Biol2023
36674842Proof-of-Concept Method to Study Uncharacterized Methyltransferases Using PRDM15.Int J Mol Sci2023
34620690Integrative RNA-omics Discovers GNAS Alternative Splicing as a Phenotypic Driver of Splicing Factor-Mutant Neoplasms.Cancer Discov2022
35401504Development of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients After 1273-mRNA SARS-CoV-2 Vaccination.Front Immunol2022
35697804Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR.Nat Biotechnol2022
35618746Pan-cancer pervasive upregulation of 3' UTR splicing drives tumourigenesis.Nat Cell Biol2022
36684069Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma.Bioeng Transl Med2022
35905714Dynamic plasticity of prostate cancer intermediate cells during androgen receptor-targeted therapy.Cell Rep2022
36065205T cell immunity is key to the pandemic endgame: How to measure and monitor it.Curr Res Immunol2022
36158208An interplay between BRD4 and G9a regulates skeletal myogenesis.Front Cell Dev Biol2022
33676077Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells.Genomics Proteomics Bioinformatics2022
33774927The duality of PRDM proteins: epigenetic and structural perspectives.FEBS J2022
35045282The portrait of liver cancer is shaped by mitochondrial genetics.Cell Rep2022
34330913PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma.Nat Commun2021
33567222Splice-Switching Antisense Oligonucleotides as a Targeted Intrinsic Engineering Tool for Generating Armored Redirected T Cells.Nucleic Acid Ther2021
33593823Mutations in <i>PRDM15</i> Are a Novel Cause of Galloway-Mowat Syndrome.J Am Soc Nephrol2021
33836156TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.Cell2021
34732729Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing.Nat Commun2021
34390647Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals.Cell Rep2021
34075878HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.Elife2021
34052526Cancer synthetic vulnerabilities to protein arginine methyltransferase inhibitors.Curr Opin Pharmacol2021
32444465Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.Cancer Discov2020
31935372Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.Cancer Cell2020
31780633circASXL1-1 regulates BAP1 deubiquitinase activity in leukemia.Haematologica2020
31950080PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly.Sci Adv2020
31819273Discovery of a first-in-class EZH2 selective degrader.Nat Chem Biol2020
33033118Mitchell-Riley syndrome iPSCs exhibit reduced pancreatic endoderm differentiation due to a mutation in <i>RFX6</i>.Development2020
33252038EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma.Elife2020
33299999Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.bioRxiv2020
33125893Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.Cell2020
32665551PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis.Nat Commun2020
32681107Global translation during early development depends on the essential transcription factor PRDM10.Nat Commun2020
32787082Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.J Med Chem2020
32923617METTL6 is a tRNA m<sup>3</sup>C methyltransferase that regulates pluripotency and tumor cell growth.Sci Adv2020
30846446The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.Development2019
31742995Identification of Quinolinols as Activators of TEAD-Dependent Transcription.ACS Chem Biol2019
31848333Discovery of a chemical probe for PRDM9.Nat Commun2019
31529049The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex.Nucleic Acids Res2019
31213506Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology.Mol Cancer Ther2019
31408619Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.Cancer Cell2019
31350521The regulation, functions and clinical relevance of arginine methylation.Nat Rev Mol Cell Biol2019
31350280CDK2 regulates the NRF1/<i>Ehmt1</i> axis during meiotic prophase I.J Cell Biol2019
31375791Author Correction: The regulation, functions and clinical relevance of arginine methylation.Nat Rev Mol Cell Biol2019
31372511The role of GRHL2 and epigenetic remodeling in epithelial-mesenchymal plasticity in ovarian cancer cells.Commun Biol2019
30711630Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.Gastroenterology2019
30833420Epigenetic Regulation of the PTEN-AKT-RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma.Cancer Res2019
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Collaborators

Diana Low
Institute of Molecular and Cell Biology (IMCB)
Co-authored papers 22
Alexander Rialdi
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Co-authored papers 10
Ivan Marazzi
Center for Epigenetics and Metabolism, University of California irvine
Co-authored papers 7
Jessica Sook Yuin Ho
Icahn School of Medicine at Mount Sinai, Duke-NUS Medical School
Co-authored papers 7
Philipp Kaldis
Co-authored papers 5
Jian Jin
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 5
Robert Sebra
Icahn School of Medicine at Mount Sinai
Co-authored papers 4
Jordi Ochando
Icahn School of Medicine at Mount Sinai
Co-authored papers 4
Randy A Albrecht
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 3
Jayantha Gunaratne
Institute of Molecular and Cell Biology
Co-authored papers 3
Minji Byun
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Adolfo Garc??a-Sastre
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Dalia Barsyte-Lovejoy
University of Toronto, College St
Co-authored papers 3
Nan Zhao
Department of Computer Science and Informatics Institute, University of Missouri
Co-authored papers 3
Simin Zheng
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Benjamin D Greenbaum
Memorial Sloan Kettering Cancer Center
Co-authored papers 3
Arvin C Dar
Co-authored papers 3
Ruby Yun-Ju Huang
National Taiwan University College of Medicine
Co-authored papers 2
Soner Yildiz
University of Geneva
Co-authored papers 2
Kris M White
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 2
Matthew T Weirauch
University of Cincinnati College of Medicine
Co-authored papers 2
Jianhe Peng
Co-authored papers 2
Laura Campisi
Icahn School of Medicine at Mount Sinai
Co-authored papers 2
Juergen A Richt
College of Veterinary Medicine, Kansas State University
Co-authored papers 2
Teresa Aydillo
Icahn School of Medicine at Mount Sinai
Co-authored papers 2
Dan Hasson
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Emily Bernstein
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