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Author Details

Rima Al-Awar
Ontario Institute for Cancer Research, University Avenue
1999
74
30
PMIDPaper TitleJournal TitlePublished Year
36793435Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.ACS Med Chem Lett2023
37660910G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions.J Biol Chem2023
36948210Discovery of Nanomolar DCAF1 Small Molecule Ligands.J Med Chem2023
37075613Targeting tumour-associated macrophages in hodgkin lymphoma using engineered extracellular matrix-mimicking cryogels.Biomaterials2023
34958585Correction to "Structure-Activity Relationship of USP5 Inhibitors".J Med Chem2022
35783295CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding.Nat Rev Chem2022
36030052G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin.J Biol Chem2022
34963044Correction to "Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma".J Med Chem2022
33476303A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.JCI Insight2021
33522809Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.J Med Chem2021
33591753A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.J Med Chem2021
34648286Structure-Activity Relationship of USP5 Inhibitors.J Med Chem2021
34589290The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia.Oncoimmunology2021
34662547Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.J Mol Biol2021
34301934Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.Nat Commun2021
34291633Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.J Med Chem2021
32369358Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.J Med Chem2020
32094923A drug discovery platform to identify compounds that inhibit EGFR triple mutants.Nat Chem Biol2020
32758183Antagonists of the serotonin receptor 5A target human breast tumor initiating cells.BMC Cancer2020
32778845Functional characterization of a PROTAC directed against BRAF mutant V600E.Nat Chem Biol2020
32409666Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.Nat Commun2020
32457299Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.Nat Commun2020
30696771Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.J Biol Chem2019
30840432Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence.ACS Chem Biol2019
31173706The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids.Cell Stem Cell2019
30359161Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9.SLAS Discov2019
30300580MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.Cancer Cell2018
30288907Discovery of an MLLT1/3 YEATS Domain Chemical Probe.Angew Chem Int Ed Engl2018
28273451Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.Cell Rep2017
28161682Preclinical evaluation of taxane-binding peptide-modified polymeric micelles loaded with docetaxel in an orthotopic breast cancer mouse model.Biomaterials2017
27076069Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy.Cell Metab2016
27618721Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay.Stem Cell Reports2016
27587383Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells.Haematologica2016
27449082Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells.Oncotarget2016
26916338Small molecules reveal an alternative mechanism of Bax activation.Biochem J2016
26958703Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).J Med Chem2016
26952093PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.J Transl Med2016
25832785Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.Apoptosis2015
26331536Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.Nature2015
26379026Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Nat Chem Biol2015
26471359WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.Cancer Res2015
26158521FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing.Cell Death Dis2015
26167872Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.Nat Chem Biol2015
26058080Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.Cancer Cell2015
24487029shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.Cancer Res2014
25330770Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.EMBO Mol Med2014
25164867Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.Nat Commun2014
25136132(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.Proc Natl Acad Sci U S A2014
22989411Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.Biochem J2013
24900672Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.ACS Med Chem Lett2013
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Collaborators

Ontario Institute for Cancer Research, University Avenue
Co-authored papers 31
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 22
University of Toronto
Co-authored papers 21
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 16
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 13
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 11
University of Toronto, College St
Co-authored papers 11
Princess Margaret Cancer Centre
Co-authored papers 7
Princess Margaret Cancer Centre
Co-authored papers 7
University of Perugia
Co-authored papers 7
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 6
Princess Margaret Cancer Centre
Co-authored papers 5
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 4
University of Toronto
Co-authored papers 4
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 4
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
University of Toronto
Co-authored papers 3
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 3
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 3
University Health Network, University of Toronto
Co-authored papers 3
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
University of Toronto
Co-authored papers 2
Hospital for Sick Children
Co-authored papers 2
University of California los angeles
Co-authored papers 2
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 2
The Hospital for Sick Children Research Institute
Co-authored papers 2
MRC Weatherall Institute of Molecular Medicine, University of Oxford
Co-authored papers 2
University of Toronto, Canada Mediterranean Institute for Life Sciences
Co-authored papers 2
2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital.
Co-authored papers 2
University of Toronto
Co-authored papers 2