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Author Details

Laura Ferraiuolo
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
2007
60
28
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36857431A cell-penetrant peptide blocking <i>C9ORF72</i>-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.Sci Transl Med2023
34767256Biological and methodological complexities of beta-amyloid peptide: Implications for Alzheimer's disease research.J Neurochem2022
35568435<i>C9ORF72</i>-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons.Life Sci Alliance2022
35628601Towards 3D Bioprinted Spinal Cord Organoids.Int J Mol Sci2022
36619668Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.Front Cell Neurosci2022
36499600Blood-Brain Barrier Disruption and Its Involvement in Neurodevelopmental and Neurodegenerative Disorders.Int J Mol Sci2022
36497181Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS.Cells2022
36241425Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.Life Sci Alliance2022
35291294Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.bioRxiv2022
35224690Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease.Cell Mol Life Sci2022
33440662Mitochondrial Dysfunction in Alzheimer's Disease: A Biomarker of the Future?Biomedicines2021
33732769A Parkinson's Disease-relevant Mitochondrial and Neuronal Morphology High-throughput Screening Assay in LUHMES Cells.Bio Protoc2021
33869658Adipose-derived stem cells protect motor neurons and reduce glial activation in both <i>in vitro</i> and <i>in vivo</i> models of ALS.Mol Ther Methods Clin Dev2021
33892003Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets.Neurosci Lett2021
34975412Emerging Mechanisms Underpinning Neurophysiological Impairments in <i>C9ORF72</i> Repeat Expansion-Mediated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia.Front Cell Neurosci2021
34963475Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity.J Neuroinflammation2021
34376242SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis.Mol Neurodegener2021
34173837DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity.Cell Mol Life Sci2021
34314817NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS.Free Radic Biol Med2021
33314575Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease.Aging Cell2021
32365522Deficits in Mitochondrial Spare Respiratory Capacity Contribute to the Neuropsychological Changes of Alzheimer's Disease.J Pers Med2020
32058042Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.Prog Neurobiol2020
32968089Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons.Sci Rep2020
32669685Applications of machine learning to diagnosis and treatment of neurodegenerative diseases.Nat Rev Neurol2020
30698736Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.Brain2019
31647549C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.Brain2019
31579294A High-throughput and Pathophysiologically Relevant Astrocyte-motor Neuron Co-culture Assay for Amyotrophic Lateral Sclerosis Therapeutic Discovery.Bio Protoc2019
30711519Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS.EBioMedicine2019
30169589Lost in translation: microRNAs mediate pathological cross-talk between motor neurons and astrocytes.Brain2018
30171839Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease.J Mol Biol2018
30195799Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS.Mol Ther Nucleic Acids2018
27965018High content analysis in amyotrophic lateral sclerosis.Mol Cell Neurosci2017
28168207Additive amelioration of ALS by co-targeting independent pathogenic mechanisms.Ann Clin Transl Neurol2017
28677678SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.Nat Commun2017
28840555Can Astrocytes Be a Target for Precision Medicine?Adv Exp Med Biol2017
26928464Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.Nat Med2016
27688759Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism.Proc Natl Acad Sci U S A2016
27716798MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.PLoS One2016
27334615The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.EMBO J2016
26780562New In Vitro Models to Study Amyotrophic Lateral Sclerosis.Brain Pathol2016
25085783Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis.Neurobiol Aging2015
26621731Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.Proc Natl Acad Sci U S A2015
26528138Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis.Front Cell Neurosci2015
25358252Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose-response study in mice and nonhuman primates.Mol Ther2015
24379375Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS.Proc Natl Acad Sci U S A2014
25411487Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex.J Neurosci2014
25233402The non-cell-autonomous component of ALS: new in vitro models and future challenges.Biochem Soc Trans2014
24750229Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.Neuropathol Appl Neurobiol2014
24607225Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.Neuron2014
23449106Neural stem cells as a therapeutic approach for amyotrophic lateral sclerosis.Mol Ther2013
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Collaborators

Pamela J Shaw
Sheffield Institute for Translational Neuroscience, University of Sheffield
Co-authored papers 34
Guillaume M Hautbergue
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Co-authored papers 12
Mimoun Azzouz
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Co-authored papers 11
Lydia M Castelli
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Co-authored papers 8
Jonathan D Cooper
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Co-authored papers 6
Cleide Dos Santos Souza
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Co-authored papers 5
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Mark O Collins
University of Sheffield
Co-authored papers 2
Jan Rehwinkel
MRC Weatherall Institute of Molecular Medicine, University of Oxford
Co-authored papers 2
Wenbin Wei
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Co-authored papers 1
Winston Hide
Harvard Medical School
Co-authored papers 1
Calum Harvey
Sheffield Institute for Translational Neuroscience, University of Sheffield
Co-authored papers 1
Andrew Peden
University of Sheffield
Co-authored papers 1
Michael P Snyder
Stanford University School of Medicine
Co-authored papers 1
David E Gordon
Emory University
Co-authored papers 1
Calum Harvey
Sheffield Institute for Translational Neuroscience, University of Sheffield
Co-authored papers 1
John Franklin
Sheffield Institute for Translational Neuroscience, University of Sheffield
Co-authored papers 1
Sai Zhang
Stanford University School of Medicine
Co-authored papers 1
Emily Graves
Sheffield Institute for Translational Neuroscience, University of Sheffield
Co-authored papers 1
Ying Sun
Co-authored papers 1
Kelly E Glajch
Neurodegenerative Diseases Research Unit
Co-authored papers 1
Andrew A Peden
University of Sheffield
Co-authored papers 1
Valerie Odon
Co-authored papers 1
Tobias Moll
Sheffield Institute for Translational Neuroscience, University of Sheffield
Co-authored papers 1
Emily Graves
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Release 1.2