Author details

Full Name

Karen Tran

Affiliation

ORCID

Career Start Year

2004

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37283743	Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response.	Front Immunol	2023
34559844	Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization.	PLoS Pathog	2021
31704807	Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses.	J Exp Med	2020
32209459	Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity.	Cell Reports	2020
31065249	Antigen-Specific Single B Cell Sorting and Monoclonal Antibody Cloning in Guinea Pigs.	Frontiers in Microbiology	2019
31732167	Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.	Immunity	2019
31092683	Correction for Khan et al., "Targeting the HIV-1 Spike and Coreceptor with Bi- and Trispecific Antibodies for Single-Component Broad Inhibition of Entry".	Journal of Virology	2019
30970260	The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization.	Cell Reports	2019
29596011	Slow Infusion of Recombinant Adeno-Associated Viruses into the Mouse Cerebrospinal Fluid Space.	Human gene therapy methods	2018
29976677	Targeting the HIV-1 Spike and Coreceptor with Bi- and Trispecific Antibodies for Single-Component Broad Inhibition of Entry.	Journal of Virology	2018
30397628	Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer.	Molecular Therapy - Methods and Clinical Development	2018
30065725	Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage.	Frontiers in Immunology	2018
29881382	Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies.	Frontiers in Immunology	2018
30102296	Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice.	Nature Biotechnology	2018
29766031	A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates.	Molecular Therapy - Methods and Clinical Development	2018
29230223	Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice.	Frontiers in Immunology	2017
28592540	Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses.	Journal of Virology	2017
28514687	Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach.	Immunity	2017
27815444	An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes.	Journal of Immunology	2016
27001051	Efficient Transduction of Corneal Stroma by Adeno-Associated Viral Serotype Vectors for Implications in Gene Therapy of Corneal Diseases.	Human Gene Therapy	2016
27487086	Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies.	PLoS Pathogens	2016
26530382	Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis.	mBio	2015
25569572	Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties.	PLoS Pathogens	2015
25892233	Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design.	Cell Reports	2015
26086867	Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.	Hum Gene Ther	2015
25979984	Correction for Ingale et al., Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies.	Journal of Virology	2015
25253346	Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies.	Journal of Virology	2014
25166308	HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization.	PLoS Pathogens	2014
22167180	Biochemically defined HIV-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the CD4-binding site.	Journal of Biological Chemistry	2012
20042513	Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription.	Journal of Virology	2010
20686030	Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.	J Virol	2010
19297489	Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription.	Journal of Virology	2009
17942546	Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits.	Journal of Virology	2008
16255039	Extracellular superoxide dismutase and oxidant damage in osteoarthritis.		2005
15256385	Extracellular superoxide dismutase attenuates lipopolysaccharide-induced neutrophilic inflammation.	American Journal of Respiratory Cell and Molecular Biology	2004
15700546	Lung inflation with direct injection of agarose: a technique for simultaneous molecular and morphometric measurements.	Experimental Lung Research	2004