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Author Details

Robert G Roeder
the Rockefeller University
1969
572
155
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36824887Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas.bioRxiv2023
37626123MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.Nat Commun2023
37696373Structural basis for evolutionarily conserved interactions between TFIIS and Paf1C.Int J Biol Macromol2023
37739210Cooperation between IRTKS and deubiquitinase OTUD4 enhances the SETDB1-mediated H3K9 trimethylation that promotes tumor metastasis via suppressing E-cadherin expression.Cancer Lett2023
37535603SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.EMBO Rep2023
37532915Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators.Nat Rev Genet2023
37419086Michael R. Green (1954-2023).Mol Cell2023
37311463Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.Mol Cell2023
37172569SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53.Cell2023
36646760Two target gene activation pathways for orphan ERR nuclear receptors.Cell Res2023
36603581Functional partitioning of transcriptional regulators by patterned charge blocks.Cell2023
35210568EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis.Nat Cell Biol2022
35394046Phosphorylated MED1 links transcription recycling and cancer growth.Nucleic Acids Res2022
36215477LYL1 facilitates AETFC assembly and gene activation by recruiting CARM1 in t(8;21) AML.Proc Natl Acad Sci U S A2022
36369505Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter.Nat Commun2022
36158200A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation.Front Cell Dev Biol2022
36255214Correction for Malik et al., "Structural and Functional Organization of TRAP220, the TRAP/Mediator Subunit That Is Targeted by Nuclear Receptors".Mol Cell Biol2022
35217626A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia.Proc Natl Acad Sci U S A2022
34187895DOT1L complex regulates transcriptional initiation in human erythroleukemic cells.Proc Natl Acad Sci U S A2021
33627428The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway.Sci Adv2021
33542097Mediator subunit MED1 is required for E2A-PBX1-mediated oncogenic transcription and leukemic cell growth.Proc Natl Acad Sci U S A2021
33888560Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues.Genes Dev2021
33526675Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout.Proc Natl Acad Sci U S A2021
34556886OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity.Nat Immunol2021
34732721Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling.Nat Commun2021
32559427The Long and the Short of BRD4: Two Tales in Breast Cancer.Mol Cell2020
31915197Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.Cancer Discov2020
33142057A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities.J Med Chem2020
33053319A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms.Cell2020
33238793Regulation of hepatocyte cell cycle re-entry by RNA polymerase II-associated Gdown1.Cell Cycle2020
33232656Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage.Mol Cell2020
32576691Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development.Proc Natl Acad Sci U S A2020
32707132The CTD Is Not Essential for the Post-Initiation Control of RNA Polymerase II Activity.J Mol Biol2020
32276273E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia.Blood2020
32381628Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle.Genes Dev2020
32298650Gene-Specific Control of tRNA Expression by RNA Polymerase II.Mol Cell2020
32268116ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase.Cell Metab2020
32231397Efficacy of a small molecule inhibitor of the transcriptional cofactor PC4 in prevention and treatment of non-small cell lung cancer.PLoS One2020
30699356Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control.Cell Rep2019
3143994150+ years of eukaryotic transcription: an expanding universe of factors and mechanisms.Nat Struct Mol Biol2019
31611376AFF1 acetylation by p300 temporally inhibits transcription during genotoxic stress response.Proc Natl Acad Sci U S A2019
31399344The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.Mol Cell2019
31566237AID-RNA polymerase II transcription-dependent deamination of IgV DNA.Nucleic Acids Res2019
30867594Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.Nature2019
31127101Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.Nat Commun2019
30755707Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation.Leukemia2019
31135261PML-RARα induces all-trans retinoic acid-dependent transcriptional activation through interaction with MED1.Transcription2019
30902546Gene-Specific H1 Eviction through a Transcriptional Activatorâ¿¿p300â¿¿NAP1â¿¿H1 Pathway.Mol Cell2019
30593567Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis.Proc Natl Acad Sci U S A2019
29171785Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.Cell Cycle2018
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Collaborators

Yoshihiro Nakatani
Dana Farber Cancer Institute
Co-authored papers 18
C David Allis
The Rockefeller University
Co-authored papers 17
Brian T Chait
The Rockefeller University
Co-authored papers 14
Wei-Yi Chen
College of Biomedical Engineering, Taiyuan University of Technology
Co-authored papers 14
Alexander Hoffmann
Co-authored papers 13
Nathaniel Heintz
Howard Hughes Medical Institute, The Rockefeller University
Co-authored papers 13
Ananda L Roy
National Institutes of Health, National Institute on Aging
Co-authored papers 12
Stephen K Burley
The State University of New Jersey
Co-authored papers 11
Tom W Muir
Princeton University
Co-authored papers 11
Ari Melnick
Co-authored papers 11
Yingming Zhao
Co-authored papers 10
Kai Ge
Co-authored papers 8
Jun Qin
Co-authored papers 7
Miki Jishage
The Rockefeller University
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Michael R Green
Co-authored papers 6
Henrik Molina
Co-authored papers 5
Philip A Cole
Brigham and Women's Hospital, Blavatnik Institute, Harvard Medical School
Co-authored papers 5
Olivier Elemento
Meyer Cancer Center
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Danny Reinberg
HHMI/NYU Langone School of Medicine
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Scott A Armstrong
Boston Children's Hospital
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Hua Chen
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Min Yu
The Rockefeller University
Co-authored papers 3
Francisco J Asturias
University of Colorado Anschutz Medical Campus
Co-authored papers 3
Roger D Kornberg
Stanford University
Co-authored papers 3
James J Bieker
Co-authored papers 3
Dae Hwan Kim
Nanoori Gangnam Hospital
Co-authored papers 3
Zhu Chen
Yong Loo Lin School of Medicine, National University of Singapore
Co-authored papers 3
Richard Koche
Memorial Sloan Kettering Cancer Center
Co-authored papers 3
Benjamin A Garcia
University of Pennsylvania
Co-authored papers 3
Nan Zhu
Shanghai General Hospital, Shanghai Jiaotong University
Co-authored papers 3
Release 1.2