Author details

Full Name

Philip C Wong

Affiliation

ORCID

Career Start Year

1990

Papers

131

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37102631	Elevated PDGF-BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRÎ² Shedding from Pericytes.		2023
37215013	Elevated nuclear TDP-43 induces constitutive exon skipping.	bioRxiv	2023
36789434	A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS.	bioRxiv	2023
37293032	Pathological Tau transmission initiated by binding lymphocyte-activation gene 3.	bioRxiv	2023
35311646	Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43.	eLife	2022
35452678	Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.	Journal of Biological Chemistry	2022
36536457	Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes.	Mol Neurodegener	2022
34987110	Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.	Journal of Neuroscience	2022
35044790	Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis.	Sci Transl Med	2022
34599968	Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice.	Journal of Biological Chemistry	2021
34050996	Brain metabolism in tau and amyloid mouse models of Alzheimer's disease: An MRI study.	NMR in Biomedicine	2021
33878375	Early detection of Alzheimer's disease using creatine chemical exchange saturation transfer magnetic resonance imaging.	Neuroimage	2021
32669023	D-Glucose uptake and clearance in the tauopathy Alzheimer's disease mouse brain detected by on-resonance variable delay multiple pulse MRI.	J Cereb Blood Flow Metab	2021
31242080	Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.		2020
31332509	Splicing repression is a major function of TDP-43 in motor neurons.	Acta Neuropathologica	2019
30553917	Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI.	Neuroimage	2019
31485326	Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the ALS mouse model.	Translational Neurodegeneration	2019
28941811	Reversible induction of TDP-43 granules in cortical neurons after traumatic injury.	Experimental Neurology	2018
28153034	Tdp-43 cryptic exons are highly variable between cell types.	Molecular Neurodegeneration	2017
28332094	Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43.	Acta Neuropathologica	2017
29034834	Challenges and Advances in Gene Therapy Approaches for Neurodegenerative Disorders.	Current Gene Therapy	2017
28017605	An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.	Curr Biol	2017
27785573	Depletion of TDP-43 decreases fibril and plaque Î²-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.	Acta Neuropathologica	2016
26744351	Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis.	Acta Neuropathologica	2016
27373369	The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model.	Nature Communications	2016
27834214	Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.	Proceedings of the National Academy of Sciences of the United States of America	2016
27681424	PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.	Cell Rep	2016
26250685	TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD.	Science	2015
25552654	Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration.	Human Molecular Genetics	2015
25965552	Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System.	Molecular Therapy - Nucleic Acids	2015
26269641	Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.	Journal of Neuroscience	2015
26308899	GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport.	Nature	2015
24646365	Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.	J Neurochem	2014
24637500	Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice.	PLoS ONE	2014
23715299	Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients.	Transl Psychiatry	2013
24120466	Altered astrocytic expression of TDP-43 does not influence motor neuron survival.	Experimental Neurology	2013
23764200	Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice.	Molecular Neurodegeneration	2013
23143281	The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes.	Journal of Neural Transmission	2013
21937983	Alzheimer's therapeutics: translation of preclinical science to clinical drug development.		2012
22608070	Rodent models of TDP-43: recent advances.	Brain Research	2012
20382452	Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.	Neurobiology of Aging	2012
21725355	Neutralization of the Î³-secretase activity by monoclonal antibody against extracellular domain of nicastrin.	Oncogene	2012
22140537	Increased expression of PS1 is sufficient to elevate the level and activity of Î³-secretase in vivo.	PLoS One	2011
21490216	Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.	Journal of Neuroscience	2011
21387148	Enhanced stability and knockdown efficiency of poly(ethylene glycol)-b-polyphosphoramidate/siRNA micellar nanoparticles by co-condensation with sodium triphosphate.	Pharmaceutical Research	2011
21418547	Selectivity to amyloid-Î² precursor protein cleavage provides hope against Alzheimer's.	Alzheimer's Research and Therapy	2011
21456963	Amyloid precursor protein processing and Alzheimer's disease.	Annual Review of Neuroscience	2011
22036569	Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent Î²-amyloid generation.	Cell	2011
21613326	Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4.	Development (Cambridge)	2011
20660762	Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.	Proceedings of the National Academy of Sciences of the United States of America	2010