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Author Details

Andrew Menzies
Wellcome Sanger Institute
2002
54
48
PMIDPaper TitleJournal TitlePublished Year
34433962The mutational landscape of human somatic and germline cells.Nature2021
33004514Extensive heterogeneity in somatic mutation and selection in the human bladder.Science2020
31996850Tobacco smoking and somatic mutations in human bronchial epithelium.Nature2020
30849372Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.Cell2019
29662167Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.Nat Genet2018
27135926Landscape of somatic mutations in 560 breast cancer whole-genome sequences.Nature2016
27615322Mutational signatures of ionizing radiation in second malignancies.Nat Commun2016
27930809ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data.Curr Protoc Bioinformatics2016
25730763Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.Nat Genet2015
26647970A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.Nat Commun2015
26678383VAGrENT: Variation Annotation Generator.Curr Protoc Bioinformatics2015
26099045Subclonal diversification of primary breast cancer revealed by multiregion sequencing.Nat Med2015
26018901Corrigendum: analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.Nat Genet2015
25999502Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.Science2015
24413735RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.Nat Genet2014
25260652Polygenic in vivo validation of cancer mutations using transposons.Genome Biol2014
25082706Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.Science2014
24714652Processed pseudogenes acquired somatically during cancer development.Nat Commun2014
23770606Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma.Nat Genet2013
24148783The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.Genome Biol2013
23778141Whole exome sequencing of adenoid cystic carcinoma.J Clin Invest2013
22608083The life history of 21 breast cancers.Cell2012
22722201The landscape of cancer genes and mutational processes in breast cancer.Nature2012
22608084Mutational processes molding the genomes of 21 breast cancers.Cell2012
20952405COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer.Nucleic Acids Res2011
21609966Data mining using the Catalogue of Somatic Mutations in Cancer BioMart.Database (Oxford)2011
21248752Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.Nature2011
21215367Massive genomic rearrangement acquired in a single catastrophic event during cancer development.Cell2011
20016485A comprehensive catalogue of somatic mutations from a human cancer genome.Nature2010
20981101The patterns and dynamics of genomic instability in metastatic pancreatic cancer.Nature2010
19906727COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer.Nucleic Acids Res2010
20054297Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.Nature2010
20016488A small-cell lung cancer genome with complex signatures of tobacco exposure.Nature2010
19377476A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.Nat Genet2009
19330029Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.Nat Genet2009
18428421The Catalogue of Somatic Mutations in Cancer (COSMIC).Curr Protoc Hum Genet2008
18469813X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment.Nat Genet2008
18438408Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing.Nat Genet2008
17236139Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.Am J Hum Genet2007
17675364Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution.Genome Res2007
17704778Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.Nat Genet2007
17668385Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly.Am J Hum Genet2007
17344846Patterns of somatic mutation in human cancer genomes.Nature2007
17436253Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus.Am J Hum Genet2007
17485433AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes.Bioinformatics2007
16175573Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.Genes Chromosomes Cancer2006
17088437Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.Mol Cancer Ther2006
17186471Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation.Am J Hum Genet2006
16406726High throughput DNA sequence variant detection by conformation sensitive capillary electrophoresis and automated peak comparison.Genomics2006
16618716A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.Cancer Res2006
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Collaborators

Wellcome Sanger Institute
Co-authored papers 44
The University of Texas MD Anderson Cancer Center
Co-authored papers 43
Wellcome Sanger Institute
Co-authored papers 42
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Co-authored papers 42
Wellcome Sanger Institute
Co-authored papers 34
Wellcome Sanger Institute
Co-authored papers 34
Wellcome Sanger Institute
Co-authored papers 34
Clinical Research Facility, Mercy University Hospital
Co-authored papers 30
Wellcome Trust Sanger Institute
Co-authored papers 24
Co-authored papers 23
University of East Anglia
Co-authored papers 22
Murdoch Children's Research Institute, Royal Children's Hospital
Co-authored papers 22
Early Cancer Institute, University of Cambridge
Co-authored papers 20
Inivata Ltd
Co-authored papers 20
Wellcome Trust Sanger Institute
Co-authored papers 19
Wellcome Trust Sanger Institute
Co-authored papers 18
Wellcome Trust Sanger Institute
Co-authored papers 17
Manchester Cancer Research Centre, University of Manchester
Co-authored papers 17
The Francis Crick Institute
Co-authored papers 16
Co-authored papers 16
Co-authored papers 15
Moores Cancer Center, university of california san diego
Co-authored papers 12
University of Cambridge
Co-authored papers 12
Wellcome Sanger Institute
Co-authored papers 11
Wellcome Sanger Institute
Co-authored papers 10
Wellcome Sanger Institute
Co-authored papers 10
Co-authored papers 10
Co-authored papers 9
University College London, UCL Cancer Institute
Co-authored papers 9
Institute of Cancer Sciences, University of Glasgow
Co-authored papers 9