Author details

Full Name

Tracey A Rouault

Affiliation

ORCID

Career Start Year

1978

Papers

214

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37552760	An iron-sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and -unwinding activities.		2023
37607904	Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming.	Nat Commun	2023
35080107	Mammalian iron sulfur cluster biogenesis: From assembly to delivery to recipient proteins with a focus on novel targets of the chaperone and co-chaperone proteins.	IUBMB Life	2022
36093377	TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model.	iScience	2022
35562883	Iron Homeostasis in the CNS: An Overview of the Pathological Consequences of Iron Metabolism Disruption.	International Journal of Molecular Sciences	2022
36061025	Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia.	Heliyon	2022
35602653	Disruption of cellular iron homeostasis by <i>IREB2</i> missense variants causes severe neurodevelopmental delay, dystonia and seizures.	Brain Commun	2022
35098635	Mammalian iron sulfur cluster biogenesis and human diseases.	IUBMB Life	2022
34593646	Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-Î±/hepcidin axis.	Proceedings of the National Academy of Sciences of the United States of America	2021
33512384	Therapeutic inhibition of HIF-2Î± reverses polycythemia and pulmonary hypertension in murine models of human diseases.	Blood	2021
34083449	Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets.	Science	2021
33402335	Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.	Sci Signal	2021
34389108	Mechanisms of cellular iron sensing, regulation of erythropoiesis and mitochondrial iron utilization.	Semin Hematol	2021
32776106	Assembly of the [4Fe-4S] cluster of NFU1 requires the coordinated donation of two [2Fe-2S] clusters from the scaffold proteins, ISCU2 and ISCA1.	Hum Mol Genet	2020
32019928	Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.	Nat Commun	2020
32311335	Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis.	Trends in Biochemical Sciences	2020
32243827	How Oxidation of a Unique Iron-Sulfur Cluster in FBXL5 Regulates IRP2 Levels and Promotes Regulation of Iron Metabolism Proteins.	Molecular Cell	2020
31918395	Mammalian iron-sulfur cluster biogenesis: Recent insights into the roles of frataxin, acyl carrier protein and ATPase-mediated transfer to recipient proteins.	Curr Opin Chem Biol	2020
33298951	Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase.	Nature Communications	2020
31498148	Potential role of iron in repair of inflammatory demyelinating lesions.	Journal of Clinical Investigation	2019
30765471	Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.	Haematologica	2019
30923992	The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways.	BioMetals	2019
30971398	Glia maturation factor-Î³ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS.	Blood advances	2019
30915432	Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome.	Brain	2019
29784770	TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation.	Blood Adv	2018
30504842	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.	Nat Commun	2018
30213870	Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress.	Blood	2018
30337301	Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of -deficient mice.	Blood advances	2018
30190349	Heme, whence come thy carbon building blocks?	Blood	2018
30321179	Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention.	PLoS ONE	2018
29309586	Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients.	Human Molecular Genetics	2018
29523684	Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells.	Journal of Biological Chemistry	2018
29480820	Translational repression of HIF2Î± expression in mice with Chuvash polycythemia reverses polycythemia.	Journal of Clinical Investigation	2018
29472371	How does hepcidin hinder ferroportin activity?	Blood	2018
29746238	Methods for Studying Iron Regulatory Protein 1: An Important Protein in Human Iron Metabolism.	Methods Enzymol	2018
29599243	Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.	Science	2018
29074498	Ferritin is secreted via 2 distinct nonclassical vesicular pathways.	Blood	2018
28615439	Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways.	Journal of Biological Chemistry	2017
28380382	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.		2017
27714045	Mammalian Fe-S proteins: definition of a consensus motif recognized by the co-chaperone HSC20.	Metallomics	2016
27026139	Mitochondrial iron overload: causes and consequences.	Current Opinion in Genetics and Development	2016
26752519	Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.	Nat Med	2016
26749241	Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.	Cell Metab	2016
26719882	SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery.	J Natl Cancer Inst	2016
28007899	Use of antisense oligonucleotides to correct the splicing error in ISCU myopathy patient cell lines.	Hum Mol Genet	2016
25245479	Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery.		2015
25771171	Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.	Neurobiology of Disease	2015
25425402	Mammalian iron-sulphur proteins: novel insights into biogenesis and function.	Nature Reviews Molecular Cell Biology	2015
26083061	Iron-sulfur proteins hiding in plain sight.	Nature Chemical Biology	2015
24606901	Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.		2014