Author details

Full Name

Eric B Fauman

Affiliation

ORCID

Career Start Year

1990

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37425837	Metabolome-wide Mendelian randomization characterizes heterogeneous and shared causal effects of metabolites on human health.	medRxiv	2023
36908397	LAVAA: a lightweight association viewer across ailments.	Bioinform Adv	2023
36777185	Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population.		2023
36504281	The genetic regulation of protein expression in cerebrospinal fluid.	EMBO Mol Med	2023
35147782	An effector index to predict target genes at GWAS loci.	Hum Genet	2022
35527238	An optimal variant to gene distance window derived from an empirical definition of cis and trans protein QTLs.	BMC Bioinformatics	2022
36357675	Rare and common genetic determinants of metabolic individuality and their effects on human health.	Nat Med	2022
36073519	Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation.	eLife	2022
35411039	Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge.	Mol Psychiatry	2022
36055244	Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.	Am J Hum Genet	2022
35302493	Effector membrane translocation biosensors reveal G protein and Î²arrestin coupling profiles of 100 therapeutically relevant GPCRs.	Elife	2022
34711957	An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci.	Nat Genet	2021
33727701	Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.	Nat Genet	2021
33414548	A cross-platform approach identifies genetic regulators of human metabolism and health.	Nat Genet	2021
34503513	Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.	BMC Med	2021
32720691	Insights into genetic variants associated with NASH-fibrosis from metabolite profiling.	Human Molecular Genetics	2020
32207686	Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria.	Elife	2020
32980178	Current Techniques for Complex Phenotypes: GWAS of the Electrocardiogram.	Trends in Genetics	2020
33230300	Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.	Nat Genet	2020
33067605	Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.	Nat Metab	2020
30887811	An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors.	J Proteome Res	2019
30239796	ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci.	Nucleic Acids Res	2019
29703844	A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.	Diabetes	2018
28199695	GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci.	Hum Mol Genet	2017
28530674	Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.	Nat Genet	2017
28369058	Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.	PLoS Genet	2017
27647854	The Genetic Landscape of Renal Complications in Type 1 Diabetes.	J Am Soc Nephrol	2017
24816252	An atlas of genetic influences on human blood metabolites.	Nat Genet	2014
24564875	GeneTopics--interpretation of gene sets via literature-driven topic models.	BMC Systems Biology	2013
23884885	Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach.	Diabetes	2013
21704549	Structure-based druggability assessment--identifying suitable targets for small molecule therapeutics.	Current Opinion in Chemical Biology	2011
18086534	Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.	J Struct Biol	2008
17126531	Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.	Epilepsy Research	2007
12647400	Structural bioinformatics in drug discovery.	Methods Biochem Anal	2003
12370306	Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352.	Molecular and Cellular Biology	2002
10779384	Analysis of a mutation in phosphodiesterase type 4 that alters both inhibitor activity and nucleotide selectivity.	Mol Pharmacol	2000
10983982	RNA methylation under heat shock control.	Molecular Cell	2000
9604936	Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A.	Cell	1998
8702535	The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.	Journal of Biological Chemistry	1996
9053905	Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.	Protein Eng	1996
8987394	Structure and function of the protein tyrosine phosphatases.	Trends in Biochemical Sciences	1996
8563637	Significance of structural changes in proteins: expected errors in refined protein structures.	Protein Sci	1995
8528087	A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase.	Protein Sci	1995
7803389	The Cys(X)5Arg catalytic motif in phosphoester hydrolysis.	Biochemistry	1994
8312270	Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A.	Biochemistry	1994
8052312	Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate.	Nature	1994
8340363	Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design.	J Biol Chem	1993
8371269	Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.	J Mol Biol	1993
1445867	Tracking conformational states in allosteric transitions of phosphorylase.	Biochemistry	1992
1881877	1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures.	Proteins	1991