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Author Details

Mareike Simon
Abramson Family Cancer Research Institute, Perelman School of Medicine
1980
284
104
Sarah J Ratcliffe (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37848248Cancer Metabolism under Limiting Oxygen Conditions.Cold Spring Harb Perspect Med2024
36808622HIF: a master regulator of nutrient availability and metabolic cross-talk in the tumor microenvironment.EMBO J2023
37703882Tumor microenvironmental nutrients, cellular responses, and cancer.Cell Chem Biol2023
37745397Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer.bioRxiv2023
35123542Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells.Cancer Metab2022
35739398NAD<sup>+</sup> regeneration drives cancer cell proliferation.Nat Metab2022
35839757GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment.Cell Metab2022
35629912A Flexible Tool to Correct Superimposed Mass Isotopologue Distributions in GC-APCI-MS Flux Experiments.Metabolites2022
36224385Activation of γ-globin expression by hypoxia-inducible factor 1α.Nature2022
35042744Hypoxia-Inducible Factors in Cancer.Cancer Res2022
33468992PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas.Oncogenesis2021
35590155A powerful tool to study metabolic reprogramming in pediatric cancers.Med2021
33795874m<sup>6</sup>A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype.Nat Cell Biol2021
33652667Systematic Identification of MACC1-Driven Metabolic Networks in Colorectal Cancer.Cancers (Basel)2021
33758423Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma.Nat Metab2021
34861885ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism.Cancer Metab2021
34547237Moonlighting functions of metabolic enzymes and metabolites in cancer.Mol Cell2021
34321458PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance.Cell Death Dis2021
34244212Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma.Cancer Discov2021
34233924Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma.Cancer Res2021
34031127Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection.Infect Immun2021
33431608Cell-Intrinsic Tumorigenic Functions of PPARγ in Bladder Urothelial Carcinoma.Mol Cancer Res2021
32346009N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma.Sci Rep2020
32098960Publisher Correction: Cellular adaptation to oxygen deficiency beyond the Nobel award.Nat Commun2020
31980651Targeting glutamine metabolism slows soft tissue sarcoma growth.Nat Commun2020
33268356Histone H3.3 beyond cancer: Germline mutations in <i>Histone 3 Family 3A and 3B</i> cause a previously unidentified neurodegenerative disorder in 46 patients.Sci Adv2020
33067597Clarifying the translational potential of B-I09.Nat Chem Biol2020
32718321DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance.Genome Biol2020
32640203Cancer Cells Don't Live Alone: Metabolic Communication within Tumor Microenvironments.Dev Cell2020
32144406Cellular adaptation to hypoxia through hypoxia inducible factors and beyond.Nat Rev Mol Cell Biol2020
32169218Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.Cell2020
32375058Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.Cell Metab2020
30586708Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature.Circulation2019
31586545Even Cancer Cells Watch Their Cholesterol!Mol Cell2019
31626776BACH1 Orchestrates Lung Cancer Metastasis.Cell2019
29330808Detection of Hypoxia and HIF in Paraffin-Embedded Tumor Tissues.Methods Mol Biol2018
29915281Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas.Oncogenesis2018
29866440PPARγ is dispensable for clear cell renal cell carcinoma progression.Mol Metab2018
30026212Transcriptional control of kidney cancer.Science2018
29915025Glutathione metabolism in cancer progression and treatment resistance.J Cell Biol2018
30184495Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation.Cell Rep2018
30154560Perseverance when the going gets tough.Nat Cell Biol2018
29959988Genetic and metabolic hallmarks of clear cell renal cell carcinoma.Biochim Biophys Acta Rev Cancer2018
29924990Hif1α Deletion Limits Tissue Regeneration via Aberrant B Cell Accumulation in Experimental Pancreatitis.Cell Rep2018
30455703Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.Front Immunol2018
29754953Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.Cell Metab2018
29381485IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.J Clin Invest2018
28842498Oxygen availability and metabolic reprogramming in cancer.J Biol Chem2017
28253108Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma.Radiology2017
26837714Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.Nat Commun2016
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Collaborators

John D Gordan
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 10
Wendy Kimryn Rathmell
Co-authored papers 7
John Alan Diehl
Case Western Reserve University School of Medicine
Co-authored papers 6
Katherine L Nathanson
Perelman School of Medicine, University of Pennsylvania, USA Abramson Cancer Center
Co-authored papers 5
Stuart H Orkin
Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School
Co-authored papers 5
Jessica A Bertout
Fred Hutchinson Cancer Research Center
Co-authored papers 5
Samuel S Lee
Co-authored papers 4
Sriram Venneti
Co-authored papers 4
John M Maris
Children's Hospital of Philadelphia
Co-authored papers 3
Aalim M Weljie
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 3
Nathaniel Heintz
Howard Hughes Medical Institute, The Rockefeller University
Co-authored papers 3
Larysa H Pevny
Co-authored papers 3
Mitchell J Weiss
Co-authored papers 2
Ramana V Davuluri
The Wistar Institute
Co-authored papers 2
Daniel G Tenen
Harvard Stem Cell Institute, Harvard Medical School
Co-authored papers 2
Chi V Dang
Johns Hopkins University School of Medicine
Co-authored papers 2
Jeremy N Rich
UPMC Hillman Cancer Center, University of Pittsburgh Medical Center
Co-authored papers 2
Vivette D D'Agati
Columbia University Irving Medical Center
Co-authored papers 2
Ian A Blair
Co-authored papers 2
Sharon Gerecht
Duke University, Johns Hopkins University
Co-authored papers 2
Susan J Fisher
University of California San Francisco
Co-authored papers 1
Yingtao Bi
Foundational Immunology, AbbVie Cambridge Research Center
Co-authored papers 1
Thomas F Floyd
The University of Texas Southwestern
Co-authored papers 1
Ian W Folkert
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Peter J Houghton
The University of Texas Health Science Center at San Antonio
Co-authored papers 1
E Alejandro Sweet-Cordero
University of California San Francisco
Co-authored papers 1
Maria Martinez-Lage
Massachusetts General Hospital
Co-authored papers 1
Sarah J Ratcliffe (CM4AI)
University of Virginia
Co-authored papers 1
Ying-Wooi Wan
Baylor College of Medicine
Co-authored papers 1
Tyler Jacks
Co-authored papers 1
Release 1.2