Author details

Full Name

Alfred H Merrill

Affiliation

ORCID

Career Start Year

1974

Papers

274

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
33152398	Brain pathology and cerebellar purkinje cell loss in a mouse model of chronic neuronopathic Gaucher disease.	Progress in Neurobiology	2021
33037133	Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures.	J Lipid Res	2020
31954175	The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells.	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids	2020
31048407	Ceramide synthase inhibition by fumonisins: a perfect storm of perturbed sphingolipid metabolism, signaling, and disease.	Journal of Lipid Research	2019
31638789	Analysis of 1-Deoxysphingoid Bases and Their -Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials.	Journal of Agricultural and Food Chemistry	2019
31636468	Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.	Nature Immunology	2019
30300671	Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.		2019
29632068	Eleven residues determine the acyl chain specificity of ceramide synthases.	Journal of Biological Chemistry	2018
30224516	Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival.	Molecular and Cellular Biology	2018
28161582	Opinion article on lipidomics: Inherent challenges of lipidomic analysis of sphingolipids.	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids	2017
28574511	Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death.	Cell Death and Differentiation	2017
28320857	Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.	Journal of Biological Chemistry	2017
29163475	Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.	Frontiers in Immunology	2017
28087695	Novel Interconnections in Lipid Metabolism Revealed by Overexpression of Sphingomyelin Synthase-1.	Journal of Biological Chemistry	2017
28280117	Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis.	Journal of Cell Science	2017
27568557	Identification of Modifier Genes in a Mouse Model of Gaucher Disease.	Cell Reports	2016
27234572	Delineating pathological pathways in a chemically induced mouse model of Gaucher disease.	Journal of Pathology	2016
26113602	Development of pheochromocytoma in ceramide synthase 2 null mice.		2015
25947379	1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma.	Journal of Biological Chemistry	2015
25947376	Introduction to Thematic Minireview Series: Novel Bioactive Sphingolipids.	Journal of Biological Chemistry	2015
25598080	Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.	J Lipid Res	2015
25064127	Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.	Nat Med	2014
25517151	Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells.	Biophysical Journal	2014
24163422	Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain.	Journal of Lipid Research	2014
24064337	Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration.	Human Molecular Genetics	2014
25241943	Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length.		2014
23283968	Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain.	Journal of Biological Chemistry	2013
24038259	Lipidomics technologies at the end of the first decade and the beginning of the next.	Advances in Nutrition	2013
24189069	25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.	J Biol Chem	2013
24019516	Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization.	Journal of Biological Chemistry	2013
23263160	Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.	Cancer Chemotherapy and Pharmacology	2013
23367521	In memoriam: Charles (Chuck) Crawford Sweeley, Jr. (1930-2012).	Journal of Lipid Research	2013
22261821	Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression.	Molecular Endocrinology	2012
22973882	Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons.	Molecular Neurodegeneration	2012
22927646	Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor.	Mol Cell Biol	2012
22539345	Modulation of ceramide synthase activity via dimerization.	Journal of Biological Chemistry	2012
22291021	Sphingosine 1-phosphate (S1P) lyase deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neurons.	Journal of Biological Chemistry	2012
22332103	Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts.	Advances in Nutrition	2012
23021221	Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.	Cell	2012
23110086	Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction.	PLoS One	2012
22231783	Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes.	Journal of Lipid Research	2012
22144673	Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain.	Journal of Biological Chemistry	2012
21983393	Lipidomics and imaging mass spectrometry.		2011
21398423	Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.	Molecular Cancer Therapeutics	2011
21303545	Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism.	BMC Syst Biol	2011
21257722	A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors.	Clinical Cancer Research	2011
21415121	A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences.	Journal of Lipid Research	2011
21314456	Adaptive control model reveals systematic feedback and key molecules in metabolic pathway regulation.	J Comput Biol	2011
21586681	Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry.	Journal of Lipid Research	2011
21749933	Analysis of mammalian sphingolipids by liquid chromatography tandem mass spectrometry (LC-MS/MS) and tissue imaging mass spectrometry (TIMS).		2011