Author details

Full Name

Hao Yin

Affiliation

ORCID

Career Start Year

2010

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
33122087	Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing.	Advanced Drug Delivery Reviews	2021
33972728	Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations.	Nature Cell Biology	2021
32926379	Chimeric DNA-RNA Guide RNA Designs.	Methods in Molecular Biology	2021
31188495	Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes.	Hepatology	2020
31740768	Adenine base editing in an adult mouse model of tyrosinaemia.	Nature Biomedical Engineering	2020
32284877	Rapid detection of African swine fever virus using Cas12a-based portable paper diagnostics.	Cell Discovery	2020
30664678	CRISPR-Cas: a tool for cancer research and therapeutics.	Nature Reviews Clinical Oncology	2019
31902584	Engineering guide RNA to reduce the off-target effects of CRISPR.	Journal of Genetics and Genomics	2019
30803822	Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9.	Molecular Therapy	2019
29597895	In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency.	Hum Gene Ther	2018
29377001	Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.	Nature Chemical Biology	2018
27956228	Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.	Gastroenterology	2017
28337020	Delivery technologies for genome editing.	Nature Reviews Drug Discovery	2017
28615073	CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion.	Genome Biol	2017
28399412	Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.	Cancer Cell	2017
29099267	Identification of cell cycle-targeting microRNAs through genome-wide screens.	Cell Cycle	2017
29131148	Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.	Nature Biotechnology	2017
26658687	RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver.	Journal of Hepatology	2016
26829318	Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo.	Nat Biotechnol	2016
26086867	Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.	Hum Gene Ther	2015
26018130	A versatile reporter system for CRISPR-mediated chromosomal rearrangements.	Genome Biol	2015
26060510	Precision cancer mouse models through genome editing with CRISPR-Cas9.	Genome Medicine	2015
24831975	Nucleic acid-mediated intracellular protein delivery by lipid-like nanoparticles.	Biomaterials	2014
25355493	Loss of Î±-catenin elicits a cholestatic response and impairs liver regeneration.	Sci Rep	2014
25354018	Ionizable amphiphilic dendrimer-based nanomaterials with alkyl-chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo.	Angew Chem Int Ed Engl	2014
24681508	Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.	Nature Biotechnology	2014
24813696	In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.	Nat Nanotechnol	2014
24623658	Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.	Advanced healthcare materials	2014
25022906	Non-viral vectors for gene-based therapy.	Nature Reviews Genetics	2014
24844798	Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice.	Nature Communications	2014
25119044	CRISPR-mediated direct mutation of cancer genes in the mouse liver.	Nature	2014
24516150	Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.	Proceedings of the National Academy of Sciences of the United States of America	2014
23882076	Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery.	Proceedings of the National Academy of Sciences of the United States of America	2013
20708156	Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.	Cancer Cell	2010