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Author Details

Ursula Grohmann
University of Perugia
1988
158
56
PMIDPaper TitleJournal TitlePublished Year
35917118Ustekinumab Tissue and Serum Levels in Patients With Crohn's Disease Are Closely Correlated Though Not Consistently Associated With Objective Response After Induction.Inflamm Bowel Dis2023
34145969Indoleamine 2,3-dioxygenase 1 (IDO1): an up-to-date overview of an eclectic immunoregulatory enzyme.FEBS J2022
35409342Critical Assessment of a Structure-Based Screening Campaign for IDO1 Inhibitors: Tips and Pitfalls.Int J Mol Sci2022
33451129The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions.Int J Mol Sci2021
33705545Vedolizumab Tissue Concentration Correlates to Mucosal Inflammation and Objective Treatment Response in Inflammatory Bowel Disease.Inflamm Bowel Dis2021
33693650Novel mutations in the WFS1 gene are associated with Wolfram syndrome and systemic inflammation.Hum Mol Genet2021
34394118Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity.Front Immunol2021
34391570Editorial overview: Indoles: very busy (and not indolent) molecules at work in immune regulation.Curr Opin Immunol2021
33968089Current Challenges for IDO2 as Target in Cancer Immunotherapy.Front Immunol2021
342902433-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.Nat Commun2021
31210557Effects of probiotic administration on immune responses of children and adolescents with type 1 diabetes to a quadrivalent inactivated influenza vaccine.Hum Vaccin Immunother2020
32024760Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.Proc Natl Acad Sci U S A2020
33055013Polyamines and Kynurenines at the Intersection of Immune Modulation.Trends Immunol2020
33159421Class IA PI3Ks regulate subcellular and functional dynamics of IDO1.EMBO Rep2020
32605792A novel mutation of indoleamine 2,3-dioxygenase 1 causes a rapid proteasomal degradation and compromises protein function.J Autoimmun2020
32994209Reply to Han et al.: On track for an IDO1-based personalized therapy in autoimmunity.Proc Natl Acad Sci U S A2020
32899743Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe?Biomolecules2020
32546647Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma.Clin Cancer Res2020
32428262Exemplifying complexity of immune suppression by a "canonical" speech: A glimpse into TNFRSF-activated signaling pathways in Treg cells.Eur J Immunol2020
32190988New Insights from Crystallographic Data: Diversity of Structural Motifs and Molecular Recognition Properties between Groups of IDO1 Structures.ChemMedChem2020
30793469IL-35Ig-expressing dendritic cells induce tolerance via Arginase 1.J Cell Mol Med2019
31724832Tracking Hidden Binding Pockets Along the Molecular Recognition Path of l-Trp to Indoleamine 2,3-Dioxygenase 1.ChemMedChem2019
31389262Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis.Expert Opin Drug Discov2019
31354721Immunoregulatory Interplay Between Arginine and Tryptophan Metabolism in Health and Disease.Front Immunol2019
31481962Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells.Front Immunol2019
31337416Wolfram syndrome, a rare neurodegenerative disease: from pathogenesis to future treatment perspectives.J Transl Med2019
30797943Amino acid metabolism as drug target in autoimmune diseases.Autoimmun Rev2019
29563329Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.JCI Insight2018
29945890Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.Diabetes2018
30236470Immune Checkpoint Molecules, Personalized Immunotherapy, and Autoimmune Diabetes.Trends Mol Med2018
30518925Induction of immunosuppressive functions and NF-κB by FLIP in monocytes.Nat Commun2018
30391205Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1.Biochem Pharmacol2018
30388851Is It Time to Use Probiotics to Prevent or Treat Obesity?Nutrients2018
29486616Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4.Expert Opin Drug Discov2018
27696702Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.J Cell Mol Med2017
30108849Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry.Medchemcomm2017
28450863The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes.Front Immunol2017
28214225A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.Immunity2017
29031064Fragment-based approach to identify IDO1 inhibitor building blocks.Eur J Med Chem2017
28771031Challenges in the design of reliable immuno-oncology mouse models to inform drug development.Future Med Chem2017
28554057The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO.Curr Opin Pharmacol2017
28825608Eating Disorders and Disordered Eating Symptoms in Adolescents with Type 1 Diabetes.Nutrients2017
28545736Amino-acid sensing and degrading pathways in immune regulation.Cytokine Growth Factor Rev2017
27647832IDO1 and TGF-β Mediate Protective Effects of IFN-α in Antigen-Induced Arthritis.J Immunol2016
26522434Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.Neuropharmacology2016
25278421LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism.Immunobiology2015
26426076IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.J Clin Invest2015
26003759Islet antigen-pulsed dendritic cells expressing ectopic IL-35Ig protect nonobese diabetic mice from autoimmune diabetes.Cytokine2015
25783564Stem cells from human amniotic fluid exert immunoregulatory function via secreted indoleamine 2,3-dioxygenase1.J Cell Mol Med2015
25729384The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals.Front Immunol2015
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Collaborators

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Co-authored papers 65
University of Perugia
Co-authored papers 32
University of Perugia
Co-authored papers 17
Department of Pharmaceutical Sciences, University of Perugia
Co-authored papers 17
University of Perugia
Co-authored papers 4
Weill Cornell School of Medicine
Co-authored papers 4
Co-authored papers 3
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 2
Department of Pharmaceutical Sciences, University of Perugia
Co-authored papers 2
Co-authored papers 2
Department of Pharmaceutical Sciences, University of Perugia
Co-authored papers 2
Englander Institute for Precision Medicine
Co-authored papers 1
Co-authored papers 1
Institute of Pharmaceutical Sciences, ETH Zurich
Co-authored papers 1
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati"
Co-authored papers 1
Weill Cornell Medical College
Co-authored papers 1
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati"
Co-authored papers 1
Wihuri Research Institute
Co-authored papers 1
University of Colorado Anschutz Medical Campus
Co-authored papers 1
National Institute of Arthritis
Co-authored papers 1
Albert Einstein College of Medicine
Co-authored papers 1
Herbert Irving Comprehensive Cancer Center, Columbia University
Co-authored papers 1
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Institute of Pharmaceutical Sciences, ETH Zurich
Co-authored papers 1
Northwestern University, Feinberg School of Medicine
Co-authored papers 1
Weill Cornell Medical College
Co-authored papers 1
Department of Pharmaceutical and Organic Chemistry, University of Granada
Co-authored papers 1
Institute of Pharmaceutical Sciences, ETH Zurich
Co-authored papers 1
Weill Cornell Medical College
Co-authored papers 1
Co-authored papers 1