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Author Details

Christopher J Paige
Princess Margaret Cancer Centre, University Health Network
1975
156
52
PMIDPaper TitleJournal TitlePublished Year
37061631Engineered murine IL-21-secreting leukemia cells induce granzyme B<sup>+</sup> T cells and CD4<sup>+</sup>CD44<sup>+</sup>CD62L<sup>-</sup> effector memory cells while suppressing regulatory T cells, leading to long-term survival.Cancer Immunol Immunother2023
32160549Neurokinin-1 Receptor Signaling Is Required for Efficient Ca<sup>2+</sup> Flux in T-Cell-Receptor-Activated T Cells.Cell Rep2020
32663467Cytotoxic CD4<sup>+</sup> T Cells in Bladder Cancer-A New License to Kill.Cancer Cell2020
30576006Differential regulation of IgA<sup>+</sup> B cells in vitro by stromal cells from distinctive anatomical compartments.J Leukoc Biol2019
31856922Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell-delivered murine leukemia model.J Immunother Cancer2019
31116977c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells.Cell Rep2019
29910711Functional Consequences of the Postnatal Switch From Neonatal to Mutant Adult Glycine Receptor α1 Subunits in the <i>Shaky</i> Mouse Model of Startle Disease.Front Mol Neurosci2018
27621226Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice.Brain Behav Immun2017
28957409Bone marrow basophils provide survival signals to immature B cells in vitro but are dispensable in vivo.PLoS One2017
29238195Cytokines and depression in cancer patients and caregivers.Neuropsychiatr Dis Treat2017
28724750Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease.J Neurosci2017
27862626Pro- and anti-inflammatory cytokine associations with major depression in cancer patients.Psychooncology2017
27933304Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.Mol Ther Methods Clin Dev2016
27618761Tumor-secreted products repress B-cell lymphopoiesis in a murine model of breast cancer.Eur J Immunol2016
25541043Hemokinin-1 is an important mediator of endotoxin-induced acute airway inflammation in the mouse.Peptides2015
26170030Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses.Blood2015
25949915CD4<sup>+</sup> T cell plasticity engenders robust immunity in response to cytokine therapy.Oncoimmunology2015
25682603Markedly perturbed hematopoiesis in acid ceramidase deficient mice.Haematologica2015
24468892Role of neurokinin 1 receptors in dextran sulfate-induced colitis: studies with gene-deleted mice and the selective receptor antagonist netupitant.Inflamm Res2014
25154710Murine splenic CD4⁺ T cells, induced by innate immune cell interactions and secreted factors, develop antileukemia cytotoxicity.Cancer Immunol Res2014
24747746Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex.Nat Med2014
23516556Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency.PLoS One2013
24251770Localized interleukin-12 delivery for immunotherapy of solid tumours.J Cell Mol Med2013
23974957GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.Nat Immunol2013
23626716Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.PLoS One2013
22130540Seasonal H1N1 influenza virus infection induces cross-protective pandemic H1N1 virus immunity through a CD8-independent, B cell-dependent mechanism.J Virol2012
22471406Diminished pheromone-induced sexual behavior in neurokinin-1 receptor deficient (TACR1(-/-)) mice.Genes Brain Behav2012
22545114Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response.PLoS One2012
22421572The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation.Semin Immunol2012
20965576Early B-cell factor regulates the expression of Hemokinin-1 in the olfactory epithelium and differentiating B lymphocytes.J Neuroimmunol2011
22158124Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.Nature2011
21873521Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells.J Immunol2011
21430229Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.J Immunol2011
21417464Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.J Med Chem2011
20660792Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development.Blood2010
18624776IL-12 immunotherapy of murine leukaemia: comparison of systemic versus gene modified cell therapy.J Cell Mol Med2009
19800893Antimicrobial properties of hemokinin-1 against strains of Pseudomonas aeruginosa.Life Sci2009
19447148Interleukin-21 regulates expression of the immediate-early lytic cycle genes and proteins in Epstein-Barr Virus infected B cells.Virus Res2009
19081134Regulatory mechanisms in the differential expression of Hemokinin-1.Neuropeptides2009
19201828IL-21: an executor of B cell fate.J Immunol2009
19260677Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.J Med Chem2009
18222514Interleukin-21 regulates expression of key Epstein-Barr virus oncoproteins, EBNA2 and LMP1, in infected human B cells.Virology2008
18522851Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3.Cell Stem Cell2008
18292505Heparan sulfate and heparin enhance ERK phosphorylation and mediate preBCR-dependent events during B lymphopoiesis.J Immunol2008
17475825Cutting edge: transplant tolerance induced by anti-CD45RB requires B lymphocytes.J Immunol2007
17954896The future of health research is hanging in the balance.CMAJ2007
17537522Co-regulated decrease of Neurokinin-1 receptor and Hemokinin-1 gene expression in monocytes and macrophages after activation with pro-inflammatory cytokines.J Neuroimmunol2007
17599344Generation and characterization of stromal cell independent IL-7 dependent B cell lines.J Immunol Methods2007
16303314IL-7: a key regulator of B lymphopoiesis.Semin Immunol2006
17142735Identification of cellular intermediates and molecular pathways induced by IL-21 in human B cells.J Immunol2006
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Collaborators

Tak W Mak
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 9
Jeffrey A Medin
Medical College of Wisconsin
Co-authored papers 6
Andrew Wakeham
Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network
Co-authored papers 5
Ekaterina Kouzmina
Queen's University
Co-authored papers 2
Megan R McCusker
Princess Margaret Cancer Centre
Co-authored papers 2
Danielle Rodin
Princess Margaret Cancer Centre, University of Toronto
Co-authored papers 2
Madeline Li
University of Toronto
Co-authored papers 2
Paul C Boutros
University of California los angeles
Co-authored papers 2
Gary Rodin
Princess Margaret Cancer Centre (University Health Network)
Co-authored papers 2
Tony Pawson
Co-authored papers 1
Peter Libby
Co-authored papers 1
Andrew J Elia
University Health Network, Princess Margaret Cancer Centre
Co-authored papers 1
Razqallah Hakem
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 1
Maya Topf
Leibniz-Institut fur Virologie (LIV)
Co-authored papers 1
Katherine A Siminovitch
University of Toronto, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
James R Woodgett
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
Anne Hakem
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
David T Scadden
Co-authored papers 1
Rama Khokha
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
Simon C Watkins
Center for Molecular Imaging, University of Pittsburgh School of Medicine
Co-authored papers 1
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