Author details

Full Name

Sylvain Meloche

Affiliation

Institute for Research in Immunology and Cancer

ORCID

Career Start Year

1982

Papers

149

H Index

Expertise

CM4AI Collaborator

Sami Nourreddine (CM4AI)

PMID	Paper Title	Journal Title	Published Year
36576983	Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy.	J Cell Physiol	2024
37097827	Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen.	ACS Chem Biol	2023
37322019	CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.	Nat Commun	2023
35041461	Signaling by the tyrosine kinase Yes promotes liver cancer development.	Sci Signal	2022
35342035	Development of a high-throughput assay to identify inhibitors of the ubiquitin-conjugating enzyme UBCH10.	SLAS Discov	2022
35529900	YES, a novel therapeutic target in hepatocellular carcinoma.	Mol Cell Oncol	2022
36612022	On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer.	Cancers (Basel)	2022
36309522	CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.	Nat Commun	2022
33177649	Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.	Oncogene	2021
33833999	Interleukin-17 Receptor D in Physiology, Inflammation and Cancer.	Front Oncol	2021
34732541	Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential.	Pharmacol Rev	2021
32709883	Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.	Nat Commun	2020
30642949	Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.	Mol Cell Biol	2019
30339711	A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.	PLoS One	2018
27924572	Isolation of Mouse Embryonic Stem Cell Lines in the Study of ERK1/2 MAP Kinase Signaling.	Methods Mol Biol	2017
28167606	Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity.	Mol Cell Biol	2017
28449575	Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.	Bioconjug Chem	2017
29038159	Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.	Mol Cell Biol	2017
27034432	Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.	Blood	2016
27446918	Redundancy in the World of MAP Kinases: All for One.	Front Cell Dev Biol	2016
27143398	Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress.	Am J Obstet Gynecol	2016
27152455	Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7Î²-Aurora A pathway.	Cell Cycle	2016
27086924	ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.	Oncogene	2016
25521218	The atypical MAPK ERK3 controls positive selection of thymocytes.	Immunology	2015
26237430	The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.	Nat Genet	2015
26235619	Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development.	Cell Rep	2015
25843717	E4F1 is a master regulator of CHK1-mediated functions.	Cell Rep	2015
24408923	ERKs in cancer: friends or foes?	Cancer Res	2014
25002529	The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival.	Mol Cell Biol	2014
25078316	Towards the development of chromone-based MEK1/2 modulators.	Eur J Med Chem	2014
25185265	UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.	Blood	2014
24732107	Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome-associated neonatal lethality in Erk3(-/-) mouse pups.	Pediatr Res	2014
24475167	The non-classical MAP kinase ERK3 controls T cell activation.	PLoS One	2014
22797077	RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.	Oncogene	2013
23687087	Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.	Blood	2013
23599344	Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.	Genes Dev	2013
23712012	Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions.	Mol Syst Biol	2013
21945831	Liver fibrosis protects mice from acute hepatocellular injury.	Gastroenterology	2012
22802335	Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia.	Blood	2012
22792062	Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.	PLoS Pathog	2012
22508986	The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.	Mol Cell Biol	2012
22669843	F-box proteins elongate translation during stress recovery.	Sci Signal	2012
22298595	Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.	Cancer Res	2012
21177870	Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.	J Biol Chem	2011
21630457	ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses.	Proteomics	2011
21683433	An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.	Cell	2011
21098080	A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.	Mol Cell Proteomics	2011
21127295	Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.	Circ Res	2011
20236090	C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.	Biochem J	2010
20956558	Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.	Mol Cell Biol	2010

1 - 50 of 149

Severa Bunda

Princess Margaret Cancer Centre

Career Start Year 2005

Number of shared co-authors 0

Yong Jae Shin

Cancer Stem Cell Research Center, Samsung Biomedical Research Institute

Career Start Year 2001

Number of shared co-authors 0

Yael Babichev

2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital.

Career Start Year 2001

Number of shared co-authors 1

Bo Ding

Nanyang First People's Hospital Affiliated to Henan University

Career Start Year 1998

Number of shared co-authors 0

Dongyan Wang

Guizhou Medical University

Career Start Year 1997

Number of shared co-authors 1

Michael A White

University of Georgia

Career Start Year 1994

Number of shared co-authors 0

Mingyao Liu

The Institute of Biomedical Sciences, East China Normal University

Career Start Year 1994

Number of shared co-authors 1

Jiefei Tong

Hospital for Sick Children

Career Start Year 1993

Number of shared co-authors 5

Karen H Martin

West Virginia University Cancer Institute, West Virginia University

Career Start Year 1993

Number of shared co-authors 0

Christoph Reinhard

Lilly Research Laboratories

Career Start Year 1992

Number of shared co-authors 0

Dario R Alessi

University of Dundee

Career Start Year 1992

Number of shared co-authors 0

Angela Cacace

O.W.) and University of Rochester Medical Center

Career Start Year 1991

Number of shared co-authors 0

Stephan M Feller

Institute of Molecular Medicine, Martin-Luther-University of Halle-Wittenberg

Career Start Year 1989

Number of shared co-authors 0

Kun-Liang Guan

University of California San Diego

Career Start Year 1988

Number of shared co-authors 2

Rakesh Kumar

Rutgers New Jersey Medical School

Career Start Year 1987

Number of shared co-authors 2

Claudio Schneider

Laboratorio Nazionale-Consorzio Interuniversitario per le Biotecnologie

Career Start Year 1987

Number of shared co-authors 1

Deborah K Morrison

Center for Cancer Research, National Cancer Institute-Frederick

Career Start Year 1985

Number of shared co-authors 1

Michael F Moran

Hospital for Sick Children, University of Toronto

Career Start Year 1985

Number of shared co-authors 6

Jorge Silvio Gutkind

Moores Cancer Center, University of California San Diego

Career Start Year 1984

Number of shared co-authors 0

James R Woodgett

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital

Career Start Year 1982

Number of shared co-authors 6

Siu-Pok Yee

University of Connecticut Health Center

Career Start Year 1981

Number of shared co-authors 1

Ze'ev Ronai

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute

Career Start Year 1981

Number of shared co-authors 2

Robert E Lewis

University of Nebraska Medical Center

Career Start Year 1980

Number of shared co-authors 0

Michael C Ostrowski

Hollings Cancer Center, Medical University of South Carolina

Career Start Year 1979

Number of shared co-authors 0

Sara A Courtneidge

Oregon Health & Science University

Career Start Year 1977

Number of shared co-authors 0

Gordon B Mills

Knight Cancer Institute, Oregon Health and Sciences University

Career Start Year 1976

Number of shared co-authors 5

Frank McCormick

Frederick National Laboratory for Cancer Research

Career Start Year 1975

Number of shared co-authors 0

Karin D Rodland

Oregon Health and Science University

Career Start Year 1973

Number of shared co-authors 1

Jonathan M Backer

Albert Einstein College of Medicine

Career Start Year 1970

Number of shared co-authors 2

Tony Hunter

Salk Institute for Biological Studies

Career Start Year 1968

Number of shared co-authors 1

row(s) 1 - 30 of 30

Marc K Saba-El-Leil

Institute for Research in Immunology and Cancer, Universite de Montreal

Co-authored papers 26

Guy Sauvageau

Universite de Montreal

Co-authored papers 8

Rafick-Pierre Sekaly

Pathology Advanced Translational Research Unit, Emory University School of Medicine

Co-authored papers 6

Jalila Chagraoui

Institute for Research in Immunology and Cancer, University of Montreal

Co-authored papers 5

Marie-Jos??e H??bert

Universite de Montreal

Co-authored papers 4

Philippe P Roux

IRIC - University of Montreal

Co-authored papers 4

Genevi??ve Lavoie

Institute for Research in Immunology and Cancer (IRIC)

Co-authored papers 3

Louis Gaboury

Institute for Research in Immunology and Cancer (IRIC), University of Montreal

Co-authored papers 3

Jana Krosl

The Leucegene Project at Institute for Research in Immunology and Cancer.

Co-authored papers 3

Anne Marinier

Institute for Research in Immunology and Cancer

Co-authored papers 3

Stephane Angers

Department of Pharmaceutical Sciences, University of Toronto

Co-authored papers 2

Ivan Topisirovic

McGill University

Co-authored papers 2

Sami Nourreddine (CM4AI)

University of California San Diego

Co-authored papers 2

Anne-Claude Gingras

Lunenfeld-Tanenbaum Research Institute

Co-authored papers 2

Sichun Lin

Department of Pharmaceutical Sciences, University of Toronto

Co-authored papers 2

Patrick Gendron

University of Montreal

Co-authored papers 2

Alisa Damnernsawad

Knight Cancer Institute, Oregon Health & Science University

Co-authored papers 1

Ronald Simon

Institute of Pathology, University Medical Center Hamburg-Eppendorf

Co-authored papers 1

Sirano Dhe-Paganon

Dana-Farber Cancer Institute

Co-authored papers 1

Fred Saad

University of Montreal Health Center

Co-authored papers 1

Christoph J Fahrni

Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology

Co-authored papers 1

Wayne A Hendrickson

Columbia University

Co-authored papers 1

Rui Chen

Co-authored papers 1

Tak W Mak

Princess Margaret Cancer Centre, University Health Network

Co-authored papers 1

Graham MacLeod

University of Toronto

Co-authored papers 1

Thibault Houles

Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal

Co-authored papers 1

Daniel Durocher

The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital

Co-authored papers 1

Trang Hoang

Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University

Co-authored papers 1

Jacob Berman

Co-authored papers 1

Stephen W Scherer

The Hospital for Sick Children

Co-authored papers 1

1 - 30

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