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Author Details

Kosuke Yusa
Wellcome Sanger Institute
2003
71
39
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36717582B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.Nat Commun2023
37576222Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma.Heliyon2023
34638130The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.Blood Adv2022
36241868AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors.Oncogene2022
36271468Author Correction: Pooled extracellular receptor-ligand interaction screening using CRISPR activation.Genome Biol2022
36228744Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin.Eur J Pharmacol2022
35171652Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.Sci Transl Med2022
35333572Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.Sci Adv2022
32764680KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.Leukemia2021
34261826Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals.Endocr J2021
32251294Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions.Nat Commun2020
32005967Author Correction: ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response.Nat Genet2020
31913353ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response.Nat Genet2020
30639098Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.Cell2019
31862961Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets.Nat Commun2019
31097696Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening.Nat Commun2019
31034882Genome-wide CRISPR-Cas9 screening in mammalian cells.Methods2019
30971826Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.Nature2019
30722791Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects.Genome Biol2019
30932271CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors.Stem Cells2019
30674557JACKS: joint analysis of CRISPR/Cas9 knockout screens.Genome Res2019
30622252ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.Nat Commun2019
29748565Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.Nat Commun2018
30103702Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting.BMC Genomics2018
29914970Genome-scale identification of cellular pathways required for cell surface recognition.Genome Res2018
29996108Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution.Cell Rep2018
30568163SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.Nat Commun2018
30477585Pooled extracellular receptor-ligand interaction screening using CRISPR activation.Genome Biol2018
29728365A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.Genome Res2018
29643451Author Correction: Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries.Sci Rep2018
28835438Molecular synergy underlies the co-occurrence patterns and phenotype of <i>NPM1</i>-mutant acute myeloid leukemia.Blood2017
28388235Applications of CRISPR genome editing technology in drug target identification and validation.Expert Opin Drug Discov2017
29174331Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.Cell Stem Cell2017
28785007Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries.Sci Rep2017
27054363Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.PLoS Genet2016
27760321A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.Cell Rep2016
25378133Off-target assessment of CRISPR-Cas9 guiding RNAs in human iPS and mouse ES cells.Genesis2015
26104701piggyBac Transposon.Microbiol Spectr2015
25408399piggyBac transposon-based insertional mutagenesis in mouse haploid embryonic stem cells.Methods Mol Biol2015
24535568Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library.Nat Biotechnol2014
25418962Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.BMC Genomics2014
25024429Removal of reprogramming transgenes improves the tissue reconstitution potential of keratinocytes generated from human induced pluripotent stem cells.Stem Cells Transl Med2014
23358416The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites.Mol Cell Biol2013
24071911Seamless genome editing in human pluripotent stem cells using custom endonuclease-based gene targeting and the piggyBac transposon.Nat Protoc2013
23908384Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase.Genome Res2013
23845441A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.Cancer Cell2013
23990560Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development.Science2013
23702683Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture.Leukemia2013
22184403The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.Blood2012
21992617Hyperactive piggyBac gene transfer in human cells and in vivo.Hum Gene Ther2012
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Collaborators

Allan Bradley
The Wellcome Trust Sanger Institute
Co-authored papers 16
Mathew J Garnett
Wellcome Sanger Institute
Co-authored papers 7
Nathalie Conte
The Wellcome Trust Sanger Institute
Co-authored papers 5
Euan A Stronach
Imperial College London
Co-authored papers 4
Julio Saez-Rodriguez
Institute of Computational Biomedicine, Heidelberg University
Co-authored papers 4
Brian J P Huntly
University of Cambridge
Co-authored papers 4
Ultan McDermott
Wellcome Sanger Institute
Co-authored papers 3
Oliver M Dovey
Co-authored papers 3
Serena Nik-Zainal
Early Cancer Institute, University of Cambridge
Co-authored papers 2
Sarah A Teichmann
Wellcome Sanger Institute
Co-authored papers 2
Jason S Carroll
Co-authored papers 2
David J Adams
Wellcome Sanger Institute
Co-authored papers 2
Rebecca Shepherd
Murdoch Children's Research Institute, Royal Children's Hospital
Co-authored papers 2
Alejandra Bruna
CRUK Cambridge Institute, University of Cambridge
Co-authored papers 2
Adam Butler
Wellcome Sanger Institute
Co-authored papers 2
Peter Ellis
Co-authored papers 2
Keiko Akagi
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Carlos Caldas
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 2
Jacqueline K White
Wellcome Trust Sanger Institute
Co-authored papers 1
Cyril H Benes
Co-authored papers 1
Kotaro Shirakawa
Graduate School of Medicine, Kyoto University
Co-authored papers 1
Wayne Yu
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
Co-authored papers 1
Bastien Gerby
Universite de Toulouse, Inserm, Universite Toulouse III-Paul Sabatier
Co-authored papers 1
Noriyuki Kijima
Osaka University Graduate School of Medicine
Co-authored papers 1
Jesse S Boehm
Broad Institute of Harvard and MIT
Co-authored papers 1
Prashant Mali (CM4AI)
University of California San Diego
Co-authored papers 1
Robert A Brodsky
Sidney Kimmel Cancer Center, Johns Hopkins University
Co-authored papers 1
Linzhao Cheng
Johns Hopkins University School of Medicine
Co-authored papers 1
Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 1
John G Doench
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