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Author Details

David L Boyle
1990
151
58
PMIDPaper TitleJournal TitlePublished Year
36993527Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium.bioRxiv2023
37993439Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis.Nat Commun2023
34963199Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.ACR Open Rheumatol2022
36035425Improving Transcriptome Fidelity Following Synovial Tissue Disaggregation.Frontiers in Medicine2022
35835913Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries.Nat Genet2022
35892413Lipopolysaccharide Exposure Differentially Alters Plasma and Brain Inflammatory Markers in Adult Male and Female Rats.Brain Sciences2022
35573706Crosstalk between CD4 T cells and synovial fibroblasts from human arthritic joints promotes hyaluronan-dependent leukocyte adhesion and inflammatory cytokine expression in vitro.Matrix Biol Plus2022
36266270Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function.Nat Commun2022
33026068Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity.Inflamm Bowel Dis2021
33544432Distinct DNA Methylation Patterns of Rheumatoid Arthritis Peripheral Blood and Synovial Tissue T Cells.ACR Open Rheumatol2021
33579724IgG Epitopes Processed and Presented by IgG<sup>+</sup> B Cells Induce Suppression by Human Thymic-Derived Regulatory T Cells.J Immunol2021
32637608Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.Sci Adv2020
31738005Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout.Arthritis and Rheumatology2020
32067517Correlation of serum protein biomarkers with disease activity in psoriatic arthritis.Expert Review of Clinical Immunology2020
30739130Toreforant, an orally active histamine H-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.Inflammation Research2019
31872186Joint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis Fibroblast-like Synoviocytes.ACR Open Rheumatol2019
30808624PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes.Ann Rheum Dis2019
29408488Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis.Biochemical Pharmacology2018
30075744Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis.Arthritis Res Ther2018
29996944Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissueArthritis Res Ther2018
29765031Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes.Nat Commun2018
27079855Cellular electrophysiological principles that modulate secretion from synovial fibroblasts.Journal of Physiology2017
28807995Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor <i>LBH</i> Gene.J Immunol2017
28935945Synovial tissue research: a state-of-the-art review.Nature reviews. Rheumatology2017
28701760Synovial tissue research: a state-of-the-art review.Nature reviews. Rheumatology2017
29255214Corrigendum: Synovial tissue research: a state-of-the-art review.Nature reviews. Rheumatology2017
27651926Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis.RMD Open2016
25378349TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.Ann Rheum Dis2016
27282753Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes.Nat Commun2016
27275015Abnormal <i>PTPN11</i> enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.JCI Insight2016
27159840LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis.Arthritis Rheumatol2016
26414708Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.Arthritis Rheumatol2016
26288175Correction: Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets.PLoS One2015
25545378Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease.Inflamm Bowel Dis2015
25398374The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.Annals of the Rheumatic Diseases2015
25901943Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets.PLoS One2015
25808728DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis.Arthritis Rheumatol2015
25995222Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.Sci Transl Med2015
24923411Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium.2014
24400116Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss.PLoS ONE2014
24244039Novel phosphoinositide 3-kinase δ,γ inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis.Journal of Pharmacology and Experimental Therapeutics2014
25041724Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis.Aliment Pharmacol Ther2014
24766912Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels.2014
24631588Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain.Pain2014
24855454Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6.Journal of Inflammation2014
23335101Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival.2013
22736089DNA methylome signature in rheumatoid arthritis.Ann Rheum Dis2013
23277489Regulation of DNA methylation in rheumatoid arthritis synoviocytes.Journal of Immunology2013
23631487An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype.Genome Med2013
23335302Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis.2013
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