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Author Details

Donald M Mock
University of Arkansas for Medical Sciences
1975
161
37
PMIDPaper TitleJournal TitlePublished Year
35274303Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival.Transfusion2022
31340188Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens.Eur J Pharm Sci2019
29193118In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage.Transfusion2018
30478521Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs-a Case Example of Erythropoietin.AAPS J2018
29770455Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations.Transfusion2018
27450367Leigh-Like Syndrome Due to Homoplasmic m.8993T>G Variant with Hypocitrullinemia and Unusual Biochemical Features Suggestive of Multiple Carboxylase Deficiency (MCD).JIMD Rep2017
28189627Population Pharmacokinetics of Darbepoetin in Infants Following Single Intravenous and Subcutaneous Dosing.J Pharm Sci2017
28099421Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities.Pediatr Res2017
28261808Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose.Transfusion2017
29076057Erratum: Leigh-Like Syndrome Due to Homoplasmic m.8993T>G Variant with Hypocitrullinemia and Unusual Biochemical Features Suggestive of Multiple Carboxylase Deficiency (MCD).JIMD Rep2017
28701385Biotin: From Nutrition to Therapeutics.J Nutr2017
26699811Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis.Expert Opin Drug Metab Toxicol2016
26327679Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis.Neuropharmacology2016
26502725A Mass Balance-Based Semiparametric Approach to Evaluate Neonatal Erythropoiesis.AAPS J2016
27215601A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups.AAPS J2016
27040455Clearance of stored red blood cells is not increased compared with fresh red blood cells in a human endotoxemia model.Transfusion2016
27039311Models for the red blood cell lifespan.J Pharmacokinet Pharmacodyn2016
25527659In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency.J Nutr2015
26363547Autologous Infant and Allogeneic Adult Red Cells Demonstrate Similar Concurrent Post-Transfusion Survival in Very Low Birth Weight Neonates.J Pediatr2015
26017162A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs.AAPS J2015
24969019Measurement of posttransfusion red cell survival with the biotin label.Transfus Med Rev2014
25320191Adequate intake of biotin in pregnancy: why bother?J Nutr2014
24088873Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion.Pediatr Res2013
24108188Tracking donor RBC survival in premature infants: agreement of multiple populations of biotin-labeled RBCs with Kidd antigen-mismatched RBCs.Pediatr Res2013
22157538Marginal biotin deficiency can be induced experimentally in humans using a cost-effective outpatient design.J Nutr2012
22780899Posttransfusion red blood cell (RBC) survival determined using biotin-labeled RBCs has distinct advantages over labeling with (51) Cr.Transfusion2012
22833654Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans.J Nutr2012
22229348Comparison of red blood cell survival in sheep determined using red blood cells labeled with either biotin at multiple densities or [14C]cyanate: validation of a model to study human physiology and disease.Transfusion2012
22023312Accelerated removal of antibody-coated red blood cells from the circulation is accurately tracked by a biotin label.Transfusion2012
20630041Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin.Transfusion2011
21918059Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans.J Nutr2011
21892638Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS.Anal Bioanal Chem2011
21905207In vivo multispectral photoacoustic and photothermal flow cytometry with multicolor dyes: a potential for real-time assessment of circulation, dye-cell interaction, and blood volume.Cytometry A2011
21051254Development and characterization of a mouse with profound biotinidase deficiency: a biotin-responsive neurocutaneous disorder.Mol Genet Metab2011
21062290Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities.Transfusion2011
21248194Urinary excretion of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans.J Nutr2011
20397702Quantitative measurement of plasma 3-hydroxyisovaleryl carnitine by LC-MS/MS as a novel biomarker of biotin status in humans.Anal Chem2010
20943794Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans.Am J Clin Nutr2010
21028833Quantitative measurement of urinary excretion of 3-hydroxyisovaleryl carnitine by LC-MS/MS as an indicator of biotin status in humans.Anal Chem2010
20561297Red blood cell (RBC) volume can be independently determined in vivo in the sheep using ovine RBCs labeled at different densities of biotin.Transfusion2010
19056638Introduction to "Advances in understanding of the biological role of biotin at the clinical, biochemical, and molecular level".J Nutr2009
19220818Red blood cell volume can be independently determined in vitro using sheep and human red blood cells labeled at different densities of biotin.Transfusion2009
19056637Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in mice.J Nutr2009
18194383A randomized clinical trial comparing immediate versus delayed clamping of the umbilical cord in preterm infants: short-term clinical and laboratory endpoints.Transfusion2008
18996865Biotin accounts for less than half of all biotin and biotin metabolites in the cerebrospinal fluid of children.Am J Clin Nutr2008
18974016Management of a patient with holocarboxylase synthetase deficiency.Mol Genet Metab2008
18541968Biotin-sensitive 3-methylcrotonylglycinuria in a patient with severe growth delay, ectodermal abnormalities, neonatal progeroid appearance, and developmental delay.Clin Dysmorphol2008
18596580Red cell volume can be accurately determined in sheep using a nonradioactive biotin label.Pediatr Res2008
18287661Biotin-protein bond: instability and structural modification to provide stability for in vivo applications.Methods Mol Biol2008
16895887Lymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans.Am J Clin Nutr2006
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Collaborators

The University of Iowa, Roy J. and Lucille A. Carver College of Medicine
Co-authored papers 32
University of Iowa Carver College of Medicine
Co-authored papers 26
Division of Pharmaceutics and Translational Therapeutics, University of Iowa
Co-authored papers 13
University of Cincinnati College of Medicine
Co-authored papers 5
Cincinnati Children's Hospital Medical Center
Co-authored papers 5
University of Amsterdam
Co-authored papers 3
University of Melbourne, The Royal Children's Hospital
Co-authored papers 2
University of Cincinnati and Cincinnati VA Medical Center
Co-authored papers 2
Co-authored papers 2
Duke University
Co-authored papers 1
Section of Clinical Genetics and Metabolism, University of Colorado
Co-authored papers 1
University of California San Diego
Co-authored papers 1
University of Texas Health Science Center at San Antonio Texas78229 USA.
Co-authored papers 1
Erasmus University Medical Center
Co-authored papers 1
Co-authored papers 1
Baystate Medical Center-University of Massachusetts Springfield
Co-authored papers 1