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Author Details

Hans Clevers
Princess Maxima Center for Pediatric Oncology
1985
787
198
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38012415Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells.Nat Immunol2024
35879361Uncovering the mode of action of engineered T cells in patient cancer organoids.Nat Biotechnol2023
38086335Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites.Cancer Cell2023
37669929A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury.Nat Commun2023
37669225Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development.J Infect Dis2023
38016960Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity.Nat Commun2023
37595032Organoid cell fate dynamics in space and time.Sci Adv2023
37591832One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids.Nat Commun2023
37555660SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid models.J Virol2023
37619220Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids.PLoS Pathog2023
37943878Targeted inhibition of Wnt signaling with a Clostridioides difficile toxin B fragment suppresses breast cancer tumor growth.PLoS Biol2023
37883554Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.Science2023
37541526Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk.Gastroenterology2023
37823774Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells.Cancer Res Commun2023
37494474Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology.Sci Transl Med2023
37532704Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures.Nat Commun2023
37157910Reuniting philosophy and science to advance cancer research.Biol Rev Camb Philos Soc2023
37020038Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities.Oncogene2023
37253730Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures.Nat Commun2023
37017636Oncogenic signaling is coupled to colorectal cancer cell differentiation state.J Cell Biol2023
37344535Author Correction: Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs.Sci Rep2023
37310627Directed Differentiation of Murine and Human Small Intestinal Organoids Toward All Mature Lineages.Methods Mol Biol2023
37178682Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification.Med2023
37137901Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss.Nat Commun2023
37435135Nanoblades allow high-level genome editing in murine and human organoids.Mol Ther Nucleic Acids2023
37068258Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants.Proc Natl Acad Sci U S A2023
37000626Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.Cell Rep2023
37126722PGE<sub>2</sub> alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate.Proc Natl Acad Sci U S A2023
36724260Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids.Proc Natl Acad Sci U S A2023
36920212Paecilomycone Inhibits Quorum Sensing in Gram-Negative Bacteria.Microbiol Spectr2023
36809334The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures.Elife2023
36538378Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation.J Clin Invest2023
36804367Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids.J Vis Exp2023
36681661DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints.Cell Death Discov2023
36602988A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology.PLoS One2023
36864051Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs.Sci Rep2023
36823355Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis.Nat Biotechnol2023
36161653Patient-derived tumor organoids predict responses to irinotecan-based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer.Int J Cancer2023
34486394Regulation of solute carriers oct2 and OAT1/3 in the kidney: a phylogenetic, ontogenetic, and cell dynamic perspective.Physiol Rev2022
35710786A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant.Cell Discov2022
35803261Human liver organoids for disease modeling of fibrolamellar carcinoma.Stem Cell Reports2022
35508177Patient-derived micro-organospheres enable clinical precision oncology.Cell Stem Cell2022
35704148In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed.Angiogenesis2022
35469014Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR ÿ LGR5 bispecific antibody with efficacy in epithelial tumors.Nat Cancer2022
35587635Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene.Microbiol Spectr2022
36459971Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.Cell Stem Cell2022
36002022Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.Cell Stem Cell2022
36042877Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.STAR Protoc2022
36058001Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy.Adv Sci (Weinh)2022
35985334Rapid tissue prototyping with micro-organospheres.Stem Cell Reports2022
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Collaborators

Marc van de Wetering
Princess Maxima Center for Pediatric Oncology
Co-authored papers 95
Edwin Cuppen
Hartwig Medical Foundation
Co-authored papers 31
Onur Basak
UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University
Co-authored papers 19
Albert J R Heck
Utrecht University
Co-authored papers 13
Frank C P Holstege
Princess Maxima Center for Pediatric Oncology
Co-authored papers 10
Jos Jonkers
Oncode Institute, Netherlands Cancer Institute
Co-authored papers 7
Bart L Haagmans
Erasmus Medical Center
Co-authored papers 7
Tokameh Mahmoudi
Erasmus University Medical Center
Co-authored papers 7
Thanasis Margaritis
Princess Maxima Center for Pediatric Oncology
Co-authored papers 7
Emile E Voest
The Netherlands Cancer Institute
Co-authored papers 7
Marielle E van Gijn
University Medical Center Groningen
Co-authored papers 6
Michael R Stratton
Wellcome Sanger Institute
Co-authored papers 6
Christine L Mummery
Leiden University Medical Center
Co-authored papers 6
Rachel H Giles
University Medical Center Utrecht
Co-authored papers 5
Jan Koster
Amsterdam University Medical Centers location AMC
Co-authored papers 5
Rudolf Grosschedl
Co-authored papers 5
Mauro J Muraro
Co-authored papers 5
Jan Paul Medema
Oncode Institute
Co-authored papers 4
Sarah A Teichmann
Wellcome Sanger Institute
Co-authored papers 4
Sten Linnarsson
Karolinska Institute
Co-authored papers 4
Fabian J Theis
Technical University of Munich
Co-authored papers 4
Shalev Itzkovitz
Co-authored papers 4
Philip Rosenstiel
Co-authored papers 4
Paul J van Diest
University Medical Center Utrecht
Co-authored papers 4
Maria Kasper
Co-authored papers 4
Christoph Klein
Kinderklinik und Kinderpoliklinik der Ludwig-Maximilians-Universitat Munchen
Co-authored papers 4
Charles L Sawyers
Memorial Sloan Kettering Cancer Center
Co-authored papers 4
Silvano Piazza
International Centre for Genetic Engineering and Biotechnology
Co-authored papers 3
Oliver Stegle
Wellcome Sanger Institute
Co-authored papers 3
Hjalmar Brismar
Royal Institute of Technology, Karolinska Institutet
Co-authored papers 3
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