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Author Details

Kevin Struhl
1976
300
114
PMIDPaper TitleJournal TitlePublished Year
37137302Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells.2023
37748648Elongation rate of RNA polymerase II affects pausing patterns across 3' UTRs.2023
37094136Condition-specific 3' mRNA isoform half-lives and stability elements in yeast.2023
35058367A compensatory link between cleavage/polyadenylation and mRNA turnover regulates steady-state mRNA levels in yeast.Proceedings of the National Academy of Sciences of the United States of America2022
359722703' Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles.Molecular and Cellular Biology2022
35482762MafB, WDR77, and ÿ-catenin interact with each other and have similar genome association profiles.PLoS One2022
36421680Nucleotide-level linkage of transcriptional elongation and polyadenylation.eLife2022
34764224Different SP1 binding dynamics at individual genomic loci in human cells.Proceedings of the National Academy of Sciences of the United States of America2021
33523865S100A8/S100A9 cytokine acts as a transcriptional coactivator during breast cellular transformation.Science advances2021
34463254YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation.Elife2021
34515029Comparison of transcriptional initiation by RNA polymerase II across eukaryotic species.eLife2021
32845240The transcriptional elongation rate regulates alternative polyadenylation in yeast.eLife2020
33144504Pheno-RNA, a method to associate genes with a specific phenotype, identifies genes linked to cellular transformation.Proceedings of the National Academy of Sciences of the United States of America2020
30681409Requirements for RNA polymerase II preinitiation complex formation in vivo.eLife2019
30337373Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming.Gut2019
30910960Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers.Proc Natl Acad Sci U S A2019
29802342Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation.Nat Commun2018
30224479Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins.Proceedings of the National Academy of Sciences of the United States of America2018
30089253Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis.Cell Reports2018
30318446Extensive Structural Differences of Closely Related 3' mRNA Isoforms: Links to Pab1 Binding and mRNA Stability.Molecular Cell2018
28920856Correction: Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo.eLife2017
28803729The Ground State and Evolution of Promoter Region Directionality.Cell2017
28699889Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo.eLife2017
27773675Mediator Undergoes a Compositional Change during Transcriptional Activation.Molecular Cell2016
27436900Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers.Proceedings of the National Academy of Sciences of the United States of America2016
26900662Transcriptome-scale RNase-footprinting of RNA-protein complexes.Nat Biotechnol2016
27626181LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer.Oncotarget2016
26687005Many lncRNAs, 5'UTRs, and pseudogenes are translated and some are likely to express functional proteins.Elife2015
25827089Mapping 3' mRNA isoforms on a genomic scale.Current Protocols in Molecular Biology2015
25784959STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer.Epigenetics Chromatin2015
25902495Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.Proc Natl Acad Sci U S A2015
25002509Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.Proceedings of the National Academy of Sciences of the United States of America2014
25279376Secondary structures involving the poly(A) tail and other 3' sequences are major determinants of mRNA isoform stability in yeast.Microbial Cell2014
24529382Global analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast.Cell2014
24623307Is DNA methylation of tumour suppressor genes epigenetic?eLife2014
24746699TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape.Molecular Cell2014
23463311Determinants of nucleosome positioning.Nat Struct Mol Biol2013
23776204Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts.Proceedings of the National Academy of Sciences of the United States of America2013
23277563Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.Proceedings of the National Academy of Sciences of the United States of America2013
23595228NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.Genome Res2013
22120719MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells.Oncogene2012
22885008A functional evolutionary approach to identify determinants of nucleosome positioning: a unifying model for establishing the genome-wide pattern.Mol Cell2012
22908280An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state.Proceedings of the National Academy of Sciences of the United States of America2012
22722849SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.Nature2012
22720264Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.Cell Rep2012
21856198JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.Molecular Cell2011
21220315Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion.Proceedings of the National Academy of Sciences of the United States of America2011
21220302Splitting of H3-H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange.Proceedings of the National Academy of Sciences of the United States of America2011
21415163Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types.Cancer Research2011
21930916Extensive divergence of yeast stress responses through transitions between induced and constitutive activation.Proc Natl Acad Sci U S A2011
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