Author details

Full Name

John Y-J Shyy

Affiliation

ORCID

Career Start Year

1995

Papers

153

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36913673	Epitranscriptional Regulation: From the Perspectives of Cardiovascular Bioengineering.	Annu Rev Biomed Eng	2023
36191258	Obstructive Sleep Apnea-induced Endothelial Dysfunction Is Mediated by miR-210.	American Journal of Respiratory and Critical Care Medicine	2023
37569694	Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children.	Int J Mol Sci	2023
36716379	Cyclic stretch promotes vascular homing of endothelial progenitor cells via Acsl1 regulation of mitochondrial fatty acid oxidation.	Proc Natl Acad Sci U S A	2023
34585841	Inpatient use of metformin and acarbose is associated with reduced mortality of COVID-19 patients with type 2 diabetes mellitus.	Endocrinology, Diabetes and Metabolism	2022
36035495	Time Domains of Hypoxia Responses and -Omics Insights.	Front Physiol	2022
35507674	JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension.	Science Translational Medicine	2022
35861833	RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease.	J Am Heart Assoc	2022
36252121	MED1 Regulates BMP/TGF-Î² in Endothelium: Implication for Pulmonary Hypertension.	Circulation Research	2022
35318857	Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2022
35013491	Endothelial-derived extracellular microRNA-92a promotes arterial stiffness by regulating phenotype changes of vascular smooth muscle cells.	Scientific Reports	2022
34806652	Role of endothelial cells in pulmonary fibrosis via SREBP2 activation.	JCI insight	2021
33644072	RAMP2-AS1 Regulates Endothelial Homeostasis and Aging.	Front Cell Dev Biol	2021
33694155	Halofuginone, a promising drug for treatment of pulmonary hypertension.	British Journal of Pharmacology	2021
33791691	Inpatient Use of Metformin and Acarbose Is Associated with Reduced Mortality of COVID-19 Patients with Type 2 Diabetes Mellitus.		2021
33468662	Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions.	Proc Natl Acad Sci U S A	2021
34001623	Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cells.	Proc Natl Acad Sci U S A	2021
33784827	SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.	Circulation Research	2021
34261329	Inflammasome Activation in Children With Kawasaki Disease and Multisystem Inflammatory Syndrome.	Arterioscler Thromb Vasc Biol	2021
33977576	Gout-induced endothelial impairment: The role of SREBP2 transactivation of YAP.	FASEB Journal	2021
33977234	Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells.	FASEB BioAdvances	2021
33186592	AMPK upregulates K2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice.	Biochemical Pharmacology	2021
34408668	Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells.	Frontiers in Physiology	2021
34669509	Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension.	Am J Physiol Cell Physiol	2021
34704831	TRPC6, a therapeutic target for pulmonary hypertension.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2021
34531976	Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization.	Pulmonary Circulation	2021
33425479	Serum miR-92a is Elevated in Children and Adults with Obstructive Sleep Apnea.		2020
32324970	MicroRNA-483 amelioration of experimental pulmonary hypertension.	EMBO Molecular Medicine	2020
32186932	Notch enhances Ca entry by activating calcium-sensing receptors and inhibiting voltage-gated K channels.	American Journal of Physiology - Cell Physiology	2020
33471718	Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19.	Endocrine Practice	2020
33257668	Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.	Nat Commun	2020
32755395	MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension.	Circulation	2020
33363178	Endocytic Adaptors in Cardiovascular Disease.	Frontiers in Cell and Developmental Biology	2020
33300001	SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2.		2020
33294172	Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension.	Pulmonary Circulation	2020
33282184	Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung.	Pulmonary Circulation	2020
33119548	microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production.	JCI insight	2020
30917677	Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (KrÃ¼ppel-Like Factor 4)-Mediated Histone Modifications.	Arterioscler Thromb Vasc Biol	2019
30578397	Germline mutation causes idiopathic pulmonary arterial hypertension.	European Respiratory Journal	2019
31182601	Shear stress regulation of miR-93 and miR-484 maturation through nucleolin.	Proc Natl Acad Sci U S A	2019
29480471	Bioinformatics Approach to Identify Novel AMPK Targets.	Methods in Molecular Biology	2018
28985241	Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents.	American Journal of Hypertension	2018
29984197	Shear Stress Regulation of Endothelium: A Double-edged Sword.	Journal of Translational Internal Medicine	2018
30052471	Atheroprone flow enhances the endothelial-to-mesenchymal transition.	American Journal of Physiology - Heart and Circulatory Physiology	2018
29570986	AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension.	American Journal of Respiratory and Critical Care Medicine	2018
28143904	AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.	Sci Signal	2017
28642237	Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization.	Arterioscler Thromb Vasc Biol	2017
28500253	LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1.	Physiol Genomics	2017
28973892	Systems biology analysis of longitudinal functional response of endothelial cells to shear stress.	Proc Natl Acad Sci U S A	2017
28794002	KrÃ¼ppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility.	Circulation	2017