Author details

Full Name

Wenqing Xu

Affiliation

ORCID

Career Start Year

1995

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37349336	Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome.		2023
36422797	Correlation Analysis of Molecularly-Defined Cortical Interneuron Populations with Morpho-Electric Properties in Layer V of Mouse Neocortex.		2023
37189394	Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/Î²-Catenin Signaling Pathway.		2023
36614183	Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from .		2023
36854761	Structural mechanism for inhibition of PP2A-B56Î± and oncogenicity by CIP2A.	Nat Commun	2023
36261529	The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron.	Nature	2022
34541573	Potent neutralizing RBD-specific antibody cocktail against SARS-CoV-2 and its mutant.		2021
34076854	Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons.		2021
33550140	Structural insights into SARS-CoV-2 infection and therapeutics development.	Stem Cell Research	2021
34315898	Cryo-EM structure of human Wntless in complex with Wnt3a.	Nature Communications	2021
33864621	High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.	Protein Cell	2021
31541192	Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors.	Oncogene	2020
32315618	Selective PP2A Enhancement through Biased Heterotrimer Stabilization.	Cell	2020
32363534	Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB<sub>2</sub>-AcpM<sub>2</sub>.	Protein Cell	2020
31892537	Crystal structure of human LDB1 in complex with SSBP2.	Proceedings of the National Academy of Sciences of the United States of America	2020
32277040	Structure of the RNA-dependent RNA polymerase from COVID-19 virus.	Science	2020
32327601	Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.	Science	2020
32272481	Structure of M<sup>pro</sup> from SARS-CoV-2 and discovery of its inhibitors.	Nature	2020
32526208	Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.	Cell	2020
33127676	Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC.	Sci Adv	2020
32512002	Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO.	J Mol Biol	2020
30826310	Purification and characterization of the extracellular region of human receptor tyrosine kinase like orphan receptor 2 (ROR2).	Protein Expr Purif	2019
30481505	Nerve growth factor metabolic dysfunction contributes to sevoflurane-induced cholinergic degeneration and cognitive impairments.	Brain Research	2019
31142515	The Highly Recurrent PP2A AÎ±-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.	Cancer Res	2019
31035307	Crystal structure of a novel ATPase RadD from Escherichia coli.	Proteins: Structure, Function and Bioinformatics	2019
30676665	Crystal structure of the LUFS domain of human single-stranded DNA binding Protein 2 (SSBP2).	Protein Science	2019
29496880	Accurate computational design of multipass transmembrane proteins.	Science	2018
30097861	Biochemical and Biophysical Assays of PAR-WWE Domain Interactions and Production of iso-ADPr for PAR-Binding Analysis.	Methods in Molecular Biology	2018
30197296	Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction.	Molecular Cell	2018
30283133	Crystal structure of a membrane-bound O-acyltransferase.	Nature	2018
29894316	High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics.	Anesthesiology	2018
29604130	Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.	Protein Science	2018
28174209	Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.	EMBO Rep	2017
28504649	Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.	J Clin Invest	2017
28546513	The SIAH E3 ubiquitin ligases promote Wnt/Î²-catenin signaling through mediating Wnt-induced Axin degradation.	Genes and Development	2017
28546512	Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.	Genes and Development	2017
27866900	A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.		2016
27350047	Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.	Protein Cell	2016
26893383	Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7).	Journal of Biological Chemistry	2016
27231341	Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling.	Journal of Biological Chemistry	2016
27050267	Crystal structure of a tankyrase 1-telomere repeat factor 1 complex.	Acta Crystallogr F Struct Biol Commun	2016
27328430	Structural insights into SAM domain-mediated tankyrase oligomerization.	Protein Science	2016
26227961	Structural basis of the Norrin-Frizzled 4 interaction.	Cell Research	2015
25327252	Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.	Nature	2015
24636259	MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex.	Developmental Cell	2014
24465839	Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.	PLoS ONE	2014
24186977	Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.	Genes and Development	2013
23857276	Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations.	Nature Communications	2013
24192037	Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes.	eLife	2013
22267412	Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.	Genes and Development	2012