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Author Details

Jonathan M Dreyfuss
Joslin Diabetes Center, Harvard Medical School
2005
69
32
PMIDPaper TitleJournal TitlePublished Year
36599833Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis.Nat Commun2023
37808767Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion.bioRxiv2023
37852413FoxK1 associated gene regulatory network in hepatic insulin action and its relationship to FoxO1 and insulin receptor mediated transcriptional regulation.Mol Metab2023
37611129Anti-Insulin Receptor Antibody for Malignant Insulinoma and Refractory Hypoglycemia.N Engl J Med2023
37503007ScreenDMT reveals linoleic acid diols replicably associate with BMI and stimulate adipocyte calcium fluxes.bioRxiv2023
38032734Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion.J Clin Invest2023
37046360Continuous glucose monitoring in patients with post-bariatric hypoglycaemia reduces hypoglycaemia and glycaemic variability.Diabetes Obes Metab2023
37230214Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.Metabolism2023
36548088Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.J Clin Invest2023
36747758Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.bioRxiv2023
35185597Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors.Front Physiol2022
36198264E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance.Cell Rep2022
33974064Glycemic Patterns Are Distinct in Post-Bariatric Hypoglycemia After Gastric Bypass (PBH-RYGB).J Clin Endocrinol Metab2021
33879610Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains.Proc Natl Acad Sci U S A2021
33649212Cysteinyl-specialized proresolving mediators link resolution of infectious inflammation and tissue regeneration via TRAF3 activation.Proc Natl Acad Sci U S A2021
34376240Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets.Genome Med2021
34506305Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex.J Clin Invest2021
34845204High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control.Nat Commun2021
32853041Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.Vasc Med2020
32040503Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes.PLoS Biol2020
32888406A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes.Cell Metab2020
32632845Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity.Geroscience2020
30530479Developmental and functional heterogeneity of white adipocytes within a single fat depot.EMBO J2019
31880793Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood.JAMA Netw Open2019
30976983Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia.Obes Surg2019
31076418Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.Diabetes Care2019
30843877SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms.JCI Insight2019
30523026FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy.Diabetes2019
30666959The Crohn's disease polymorphism, <i>ATG16L1</i> T300A, alters the gut microbiota and enhances the local Th1/Th17 response.Elife2019
29539432Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites.Cell Rep2018
29860335Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes.J Clin Endocrinol Metab2018
28714135YAP suppresses gluconeogenic gene expression through PGC1α.Hepatology2017
28199304Adipose-derived circulating miRNAs regulate gene expression in other tissues.Nature2017
28252345Evidence of stress in β cells obtained with laser capture microdissection from pancreases of brain dead donors.Islets2017
28380379β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance.Cell Metab2017
28345670Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.Nat Commun2017
28492253Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues.Nature2017
29241534Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes.Cell Rep2017
26858359Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice.Diabetes2016
27852976Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function.Aging (Albany NY)2016
27689005Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism.Mol Metab2016
27775551Antibiotic effects on gut microbiota and metabolism are host dependent.J Clin Invest2016
27531045Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells.Int J Obes (Lond)2016
25804930Associations of cord blood metabolites with early childhood obesity risk.Int J Obes (Lond)2015
26377923Metabolic modeling predicts metabolite changes in Mycobacterium tuberculosis.BMC Syst Biol2015
26076036Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.Nat Med2015
26196144Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence.Elife2015
25737951Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes.Mol Metab2015
23935467Reconstruction and validation of a genome-scale metabolic model for the filamentous fungus Neurospora crassa using FARM.PLoS Comput Biol2013
23823726The Mycobacterium tuberculosis regulatory network and hypoxia.Nature2013
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Collaborators

Peter J Park
Harvard Medical School
Co-authored papers 10
Marco F Ramoni
Children's Hospital Informatics Program, Harvard Medical School
Co-authored papers 5
Simon Kasif
Boston University
Co-authored papers 4
Elvira Isganaitis
Co-authored papers 4
Ashok Kumar Jayavelu
German Cancer Research Center (DKFZ)
Co-authored papers 3
Robert E Gerszten
Co-authored papers 3
Jeremy Zucker
Pacific Northwest National Laboratory
Co-authored papers 2
Cynthia C Morton
Co-authored papers 2
Matthias Mann
Max-Planck Institute of Biochemistry
Co-authored papers 2
Kevin Fitzgerald
Co-authored papers 2
Aldons J Lusis
Co-authored papers 2
Krishna S Nair
Co-authored papers 2
Emily Oken
Co-authored papers 2
Leila Noetzli
Co-authored papers 2
Clary B Clish
Broad Institute of MIT and Harvard
Co-authored papers 2
Lynn Bry
Co-authored papers 2
Aleksandar D Kostic
Co-authored papers 2
Birgit Schilling
Buck Institute for Research on Aging
Co-authored papers 2
Jonathan Liu
Co-authored papers 1
Suzanne Devkota
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 1
Stephen S Rich
Co-authored papers 1
Peter M Black
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 1
Sudha B Biddinger
Co-authored papers 1
Tyler Jacks
Co-authored papers 1
Penelope A Morel
University of Pittsburgh
Co-authored papers 1
Amy J Wagers
Joslin Diabetes Center
Co-authored papers 1
Ashwin N Ananthakrishnan
Co-authored papers 1
Stephen J Chanock
National Cancer Institute, National Institutes of Health
Co-authored papers 1
Daniel Levner
Emulate Inc.
Co-authored papers 1
Ramnik J Xavier
Broad Institute of MIT and Harvard
Co-authored papers 1
Release 1.2