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Author Details

Andrew P VanDemark
University of Pittsburgh
2000
44
23
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36893255Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.Science2023
37678706The Cytotoxic Mycobacteriophage Protein Phaedrus gp82 Interacts with and Modulates the Activity of the Host ATPase, MoxR.J Mol Biol2023
37327313Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.Proc Natl Acad Sci U S A2023
35315486Itavastatin and resveratrol increase triosephosphate isomerase protein in a newly identified variant of TPI deficiency.Dis Model Mech2022
36379252On the illusion of auxotrophy: met15ο yeast cells can grow on inorganic sulfur, thanks to the previously uncharacterized homocysteine synthase Yll058w.J Biol Chem2022
35101798Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death.Redox Biol2022
33126055Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis.Redox Biol2021
32513718PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells.Proc Natl Acad Sci U S A2020
32274853Structural and functional divergence of GDAP1 from the glutathione S-transferase superfamily.FASEB J2020
31075491Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo.Biochim Biophys Acta Mol Basis Dis2019
31383866The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway.Nat Commun2019
30762363Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members.J Chem Inf Model2019
30525572Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE.J Am Chem Soc2018
29053969PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.Cell2017
28117766Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins.J Vis Exp2017
27031109Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics.PLoS Genet2016
27758857Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity.J Biol Chem2016
27840029The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6.Mol Cell2016
25463631Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency.Biochim Biophys Acta2015
26215801Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52.Nat Commun2015
24161951Cross-talk between diverse serine integrases.J Mol Biol2014
25171888The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice.Biol Open2014
24112940The structure of Xis reveals the basis for filament formation and insight into DNA bending within a mycobacteriophage intasome.J Mol Biol2014
23460207The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.Nucleic Acids Res2013
24349032Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology.PLoS One2013
24101474Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin.Proc Natl Acad Sci U S A2013
23641070Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.J Cell Sci2013
22318720Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin.J Biol Chem2012
22950046A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease.Brain Behav2012
22493320Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.Mol Biol Cell2012
20352123Dissection of structure and function of the N-terminal domain of mouse DNMT1 using regional frame-shift mutagenesis.PLoS One2010
18089575Structural and functional analysis of the Spt16p N-terminal domain reveals overlapping roles of yFACT subunits.J Biol Chem2008
17803945Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation.Mol Cell2007
17942675Potent D-peptide inhibitors of HIV-1 entry.Proc Natl Acad Sci U S A2007
16678108The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition.Mol Cell2006
15721250E1 on the move.Mol Cell2005
16141067Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.Science2005
15452557Grabbing E2 by the tail.Nat Struct Mol Biol2004
12660720Two-stepping with E1.Nat Struct Biol2003
12005425SUMO wrestling with specificity.Structure2002
12504688Structural basis of ubiquitylation.Curr Opin Struct Biol2002
11440714Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.Cell2001
10722750Characterization of the N-terminal domain of the yeast transcriptional repressor Tup1. Proposal for an association model of the repressor complex Tup1 x Ssn6.J Biol Chem2000
11062549Opening doors into the proteasome.Nat Struct Biol2000
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Collaborators

Center for Free Radical and Antioxidant Health, University of Pittsburgh
Co-authored papers 7
Laufer Center for Physical and Quantitative Biology, Stony Brook University
Co-authored papers 7
Center for Molecular Imaging, University of Pittsburgh School of Medicine
Co-authored papers 4
Co-authored papers 3
University of Pittsburgh
Co-authored papers 3
UPMC-Hillman Cancer Center, University of Pittsburgh
Co-authored papers 2
Spectral Medical Inc.
Co-authored papers 2
University of Pittsburgh
Co-authored papers 2
H. Lee. Moffitt Cancer Center
Co-authored papers 1
University of Pittsburgh
Co-authored papers 1
University of Pittsburgh, USA Pittsburgh Center for Evolutionary Biology and Medicine
Co-authored papers 1
University of Pittsburgh
Co-authored papers 1
University of Pittsburgh
Co-authored papers 1
Co-authored papers 1
College of Resources and Environmental Sciences, Nanjing Agricultural University
Co-authored papers 1
Moffitt Cancer Center and Research Institute
Co-authored papers 1
Co-authored papers 1
Moffitt Cancer Center and Research Institute
Co-authored papers 1
Seoul National University
Co-authored papers 1
University of Pittsburgh School of Medicine
Co-authored papers 1
University of Pittsburgh School of Medicine
Co-authored papers 1
Columbia University
Co-authored papers 1
Co-authored papers 1
Center for Critical Care Nephrology, University of Pittsburgh School of Medicine
Co-authored papers 1
University of California San Diego
Co-authored papers 1
Karolinska Institute
Co-authored papers 1
Co-authored papers 1
University of Pittsburgh School of Medicine.
Co-authored papers 1
University of Pittsburgh
Co-authored papers 1
Co-authored papers 1