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Author Details

Constance L Cepko
Howard Hughes Medical Institute, Harvard Medical School
1981
260
100
Kirsten Obernier (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37460158Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism.Cold Spring Harb Perspect Med2024
37252956Chromophore supply modulates cone function and survival in retinitis pigmentosa mouse models.Proc Natl Acad Sci U S A2023
37961274High temporal frequency light response in mouse retina is mediated by ON and OFF bipolar cells and requires FAT3 signaling.bioRxiv2023
34534525Development and diversification of bipolar interneurons in the mammalian retina.Dev Biol2022
36216958Light-Seq: light-directed in situ barcoding of biomolecules in fixed cells and tissues for spatially indexed sequencing.Nat Methods2022
35045975Mouse Lines with Cre-Mediated Recombination in Retinal Amacrine Cells.eNeuro2022
35315776Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration.Elife2022
35251042Targeting Microglia to Treat Degenerative Eye Diseases.Front Immunol2022
34986354Spatiotemporal patterns of neuronal subtype genesis suggest hierarchical development of retinal diversity.Cell Rep2022
34083252A High-Density Narrow-Field Inhibitory Retinal Interneuron with Direct Coupling to Müller Glia.J Neurosci2021
33491671Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa.JCI Insight2021
33568518Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses.Sci Transl Med2021
33847261AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa.Elife2021
33929509Cis-regulatory dissection of cone development reveals a broad role for Otx2 and Oc transcription factors.Development2021
34197341Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration.JCI Insight2021
32352930Microglia modulation by TGF-β1 protects cones in mouse models of retinal degeneration.J Clin Invest2020
33659409Probe-Seq: Method for RNA Sequencing of Specific Cell Types from Animal Tissue.Bio Protoc2020
34853795Clinical Assessment and Validation of a Rapid and Sensitive SARS-CoV-2 Test Using Reverse Transcription Loop-Mediated Isothermal Amplification Without the Need for RNA Extraction.Open Forum Infect Dis2020
31728515FIN-Seq: transcriptional profiling of specific cell types from frozen archived tissue of the human central nervous system.Nucleic Acids Res2020
32027825Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.Neuron2020
33209963<i>In Situ</i> Detection of Adeno-associated Viral Vector Genomes with SABER-FISH.Mol Ther Methods Clin Dev2020
32631829Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and <i>cis</i>-regulatory modules in the retina.Development2020
32900935SARS-CoV-2 detection using isothermal amplification and a rapid, inexpensive protocol for sample inactivation and purification.Proc Natl Acad Sci U S A2020
31110282SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues.Nat Methods2019
31815670Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation.Elife2019
31822210High-throughput dense reconstruction of cell lineages.Open Biol2019
31849618Adeno-Associated Virus Technologies and Methods for Targeted Neuronal Manipulation.Front Neuroanat2019
30833387AAV <i>cis</i>-regulatory sequences are correlated with ocular toxicity.Proc Natl Acad Sci U S A2019
31036641Soluble CX3CL1 gene therapy improves cone survival and function in mouse models of retinitis pigmentosa.Proc Natl Acad Sci U S A2019
29721937In Vivo Functional Imaging of Retinal Neurons Using Red and Green Fluorescent Calcium Indicators.Adv Exp Med Biol2018
29529016Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization.Nat Med2018
27980033The brain parenchyma has a type I interferon response that can limit virus spread.Proc Natl Acad Sci U S A2017
28472646Epigenomics of Retinal Development in Mice and Humans.Neuron2017
28598329Glycolytic reliance promotes anabolism in photoreceptors.Elife2017
28648799Fgf8 Expression and Degradation of Retinoic Acid Are Required for Patterning a High-Acuity Area in the Retina.Dev Cell2017
28815497Viral Delivery of GFP-Dependent Recombinases to the Mouse Brain.Methods Mol Biol2017
26729030Anterograde or Retrograde Transsynaptic Circuit Tracing in Vertebrates with Vesicular Stomatitis Virus Vectors.Curr Protoc Neurosci2016
26427452Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages.Adv Exp Med Biol2016
27818507The origin and evolution of cell types.Nat Rev Genet2016
27565351Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics.Cell2016
27205882Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies.Elife2016
27116662Photoreceptor Fate Determination in the Vertebrate Retina.Invest Ophthalmol Vis Sci2016
25798616NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage.J Clin Invest2015
28532380The Determination of Rod and Cone Photoreceptor Fate.Annu Rev Vis Sci2015
26299474Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.Neuron2015
26299473Clonally Related Forebrain Interneurons Disperse Broadly across Both Functional Areas and Structural Boundaries.Neuron2015
26339064Preferential Budding of Vesicular Stomatitis Virus from the Basolateral Surface of Polarized Epithelial Cells Is Not Solely Directed by Matrix Protein or Glycoprotein.J Virol2015
26258682Cell type-specific manipulation with GFP-dependent Cre recombinase.Nat Neurosci2015
26091041Embryonic Origin of Postnatal Neural Stem Cells.Cell2015
26190977Neuroanatomy goes viral!Front Neuroanat2015
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Collaborators

Jeffrey M Trimarchi
Inc., Lehigh University
Co-authored papers 16
Christopher P Austin
St. George's University Medical School
Co-authored papers 11
Seth Blackshaw
Johns Hopkins University School of Medicine.
Co-authored papers 10
Claudio Punzo
University of Massachusetts Medical School
Co-authored papers 9
Christopher A Walsh
Broad Institute of MIT and Harvard
Co-authored papers 8
Eugene Drokhlyansky
Co-authored papers 7
Ashutosh P Jadhav
Barrow Neurological Institute, St Joseph's Hospital and Medical Center
Co-authored papers 6
Winston Patrick Kuo
Harvard School of Dental Medicine
Co-authored papers 6
Li Cai
University of Texas MD Anderson Cancer Center
Co-authored papers 6
Lucila Ohno-Machado
Co-authored papers 5
Seo-Hee Cho
Lewis Katz School of Medicine, Temple University
Co-authored papers 5
Lucila Ohno-Machado
Escola de Administracao de Empresas - FGV, Stanford University, University of California San Diego, University of Sao Paulo, Yale School of Medicine
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Sanjiv Harpavat
Baylor College of Medicine
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Howard Hughes Medical Institute, Blavatnik Institute, Harvard Medical School
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Institute of Molecular and Clinical Ophthalmology Basel
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Fang Liu
Institute for Cancer Research, Norwegian Radium Hospital
Co-authored papers 3
Jonathan G Seidman
Harvard Medical School
Co-authored papers 3
Benoit G Bruneau
Gladstone Institutes of Cardiovascular Disease, Gladstone Institutes
Co-authored papers 3
Peter J Park
Harvard Medical School
Co-authored papers 3
Eivind Hovig
Center for Bioinformatics, University of Oslo
Co-authored papers 3
David G Birch
Retina Foundation of the Southwest
Co-authored papers 3
Evan Y Snyder
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 3
Christine E Seidman
Brigham and Women's Hospital (Y.K.
Co-authored papers 3
Fran??ois Guillemot
the Francis Crick Institute
Co-authored papers 2
Timothy J Cherry
University of Washington
Co-authored papers 2
Tor-Kristian Jenssen
Norwegian University of Science and Technology
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Norbert Perrimon
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David R Liu
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Release 1.2