Author details

Full Name

Mallika Sastry

Affiliation

ORCID

Career Start Year

1990

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37098956	Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.		2023
37989731	Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site.		2023
36119018	Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens.	Frontiers in Immunology	2022
35841885	Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability.	Structure	2022
34551978	Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses.	Proceedings of the National Academy of Sciences of the United States of America	2021
33271067	Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.	Cell Host Microbe	2020
32130953	VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.	Cell Host Microbe	2020
32637958	Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains.	bioRxiv	2020
30995238	Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting.	PLoS One	2019
30876875	Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.	Immunity	2019
31348886	Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.	Cell	2019
29867235	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.	Nat Med	2018
28166380	Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins.	ChemBioChem	2017
28445724	Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.	Cell Rep	2017
29212041	Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains.	Cell Reports	2017
29073183	Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus.	PLoS ONE	2017
27583777	Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant.	Bioconjugate Chemistry	2016
27478931	Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.	Nat Struct Mol Biol	2016
27463224	Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus.	PLoS One	2016
26098893	A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus.	PLoS One	2015
25740988	Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.	Journal of Virology	2015
26098315	Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.	Nat Struct Mol Biol	2015
26468324	Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera.	Sci Transl Med	2015
26577736	Effective isotope labeling of proteins in a mammalian expression system.	Methods in Enzymology	2015
24179220	Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.	Science	2013
23076586	Mammalian expression of isotopically labeled proteins for NMR spectroscopy.	Advances in Experimental Medicine and Biology	2012
22113616	Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.	Nature	2011
21667299	Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy.	Journal of Biomolecular NMR	2011
16910638	Cyclic peptide helices: a hybrid beta-hairpin/beta-helical supersecondary structure.	Journal of the American Chemical Society	2006
15324754	Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction.	J Magn Reson	2004
11902843	A structural basis for S100 protein specificity derived from comparative analysis of apo and Ca(2+)-calcyclin.	J Mol Biol	2002
9836578	Rational design of a functional metalloenzyme: introduction of a site for manganese binding and oxidation into a heme peroxidase.	Biochemistry	1998
9519412	The three-dimensional structure of Ca(2+)-bound calcyclin: implications for Ca(2+)-signal transduction by S100 proteins.	Structure	1998
7707379	Solution structure of the monoalkylated mitomycin C-DNA complex.	J Mol Biol	1995
7666419	Solution structure of mithramycin dimers bound to partially overlapping sites on DNA.	J Mol Biol	1995
8329387	Solution structure of the mithramycin dimer-DNA complex.	Biochemistry	1993
2346750	NMR and computational characterization of mitomycin cross-linked to adjacent deoxyguanosines in the minor groove of the d(T-A-C-G-T-A).d(T-A-C-G-T-A) duplex.	Biochemistry	1990