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Author Details

Feyruz V Rassool
University of Maryland Greenebaum Comprehensive Cancer Center
1984
84
41
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34808460PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers.Transl Oncol2022
35759659Activating STING1-dependent immune signaling in <i>TP53</i> mutant and wild-type acute myeloid leukemia.Proc Natl Acad Sci U S A2022
35681619Pharmacologic Induction of BRCAness in <i>BRCA</i>-Proficient Cancers: Expanding PARP Inhibitor Use.Cancers (Basel)2022
36009550LLL12B, a Novel Small-Molecule STAT3 Inhibitor, Induces Apoptosis and Suppresses Cell Migration and Tumor Growth in Triple-Negative Breast Cancer Cells.Biomedicines2022
35091444Phase I Clinical Trial of DNA Methyltransferase Inhibitor Decitabine and PARP Inhibitor Talazoparib Combination Therapy in Relapsed/Refractory Acute Myeloid Leukemia.Clin Cancer Res2022
34504649Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication.Oncotarget2021
33822747How Epigenetic Therapy Beats Adverse Genetics in Monosomy Karyotype AML.Cancer Res2021
32238799Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells.Cell Death Dis2020
32824412Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR.Int J Mol Sci2020
32651270Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency.Proc Natl Acad Sci U S A2020
30691684Exploiting epigenetically mediated changes: Acute myeloid leukemia, leukemia stem cells and the bone marrow microenvironment.Adv Cancer Res2019
31591209DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.Proc Natl Acad Sci U S A2019
30953707Partnering with PARP inhibitors in acute myeloid leukemia with FLT3-ITD.Cancer Lett2019
29615458An Effective Epigenetic-PARP Inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA Mutations.Clin Cancer Res2018
30389813Retraction: Aromatase Inhibitor-mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer.Mol Cancer Ther2018
28486105CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.Cancer Cell2017
26797621Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2.Pharmaceuticals (Basel)2016
27728808Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.Cancer Cell2016
27688775High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature.Stem Cells Int2016
27374090Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress.Oncotarget2016
27064363Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin.Leuk Res2016
25766563A "RANning" leap with "XPOrt" into TKI resistance.Blood2015
25828893c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias.Mol Cancer Res2015
25976679Aromatase Inhibitor-Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer.Mol Cancer Ther2015
23958061Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome.Leuk Res2014
25441683High frequency of rare structural chromosome abnormalities at relapse of cytogenetically normal acute myeloid leukemia with FLT3 internal tandem duplication.Cancer Genet2014
24163065Vascular progenitors from cord blood-derived induced pluripotent stem cells possess augmented capacity for regenerating ischemic retinal vasculature.Circulation2014
22641215Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias.Oncogene2013
23836560Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.Blood2013
22995214DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity.Biochim Biophys Acta2013
22112941Targeting abnormal DNA repair in therapy-resistant breast cancers.Mol Cancer Res2012
23088869HDAC inhibitors: roles of DNA damage and repair.Adv Cancer Res2012
22439938Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells.Cancer Cell2012
22427031Genomic instability in chronic myeloid leukemia: targets for therapy?Curr Hematol Malig Rep2012
21228325Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice.Blood2011
21543117KLFs and ATRA-induced differentiation: new pathways for exploitation.Leuk Res2011
21718709Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining.Mutat Res2011
20219246Regulation of differentiation by a PHD domain in the NUP98-PHF23 fusion protein.Leuk Res2010
20697770Targeting abnormal DNA double strand break repair in cancer.Cell Mol Life Sci2010
20841480Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells.Cancer Res2010
20807885Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy.Blood2010
18192505Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML.Blood2008
18467025Genomic instability in myeloid malignancies: increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair.Cancer Lett2008
18524993Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks.Blood2008
18524763BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner.J Biol Chem2008
17875717Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?Cancer Res2007
16545529Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA that is important to mdr1 gene amplification reveals a novel gene whose expression is associated with spermatocyte and adipocyte differentiation.Gene2006
16877702Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis?Mol Cancer Res2006
14737073Differentially expressed genes in adult familial myelodysplastic syndromes.Leukemia2004
12691817DNA double strand breaks (DSB) and non-homologous end joining (NHEJ) pathways in human leukemia.Cancer Lett2003
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Collaborators

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
Co-authored papers 11
Institute for Cell Engineering, The Johns Hopkins University School of Medicine
Co-authored papers 3
Johns Hopkins University School of Medicine
Co-authored papers 3
Center for Stem Cell Biology & Regenerative Medicine and.
Co-authored papers 2
Maastricht University Medical Center
Co-authored papers 2
Daegu Catholic University Medical Center, Catholic University of Daegu
Co-authored papers 2
Johns Hopkins University School of Medicine
Co-authored papers 2
University of Michigan ann arbor
Co-authored papers 2
Livestrong Cancer Institutes, Dell Medical School, University of Texas at Austin
Co-authored papers 2
University of Texas Southwestern Medical Center at Dallas
Co-authored papers 2
Montefiore Medical Center
Co-authored papers 1
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
Co-authored papers 1
Medical Research Council Cancer Unit, University of Cambridge
Co-authored papers 1
University of California San Diego
Co-authored papers 1
Queen's University
Co-authored papers 1
University of British Columbia
Co-authored papers 1
Johns Hopkins University School of Medicine
Co-authored papers 1
Tangdu Hospital, Fourth Military Medical University
Co-authored papers 1
University of British Columbia
Co-authored papers 1
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Center for Comparative Medicine, Baylor College of Medicine
Co-authored papers 1
Johns Hopkins University School of Medicine
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Meyer Cancer Center
Co-authored papers 1
Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine
Co-authored papers 1
Ajou University
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University of Adelaide
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Ghent University
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Dana-Farber Cancer Institute
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