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Author Details

Mike Tyers
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
1986
231
88
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36890145A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay.Sci Rep2023
37595512Absolute quantification of protein number and dynamics in single cells.Curr Opin Struct Biol2023
37639469Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations.PLoS Genet2023
37977119Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition.Mol Cell2023
36890145A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay.Sci Rep2023
37595512Absolute quantification of protein number and dynamics in single cells.Curr Opin Struct Biol2023
37977119Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition.Mol Cell2023
37639469Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations.PLoS Genet2023
34731885Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.Blood Adv2022
36305789Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.J Cell Biol2022
35864841Head-to-tail cyclization of side chain-protected linear peptides to recapitulate genetically-encoded cyclized peptides.Pept Sci (Hoboken)2022
35482514The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor.Mol Biol Cell2022
36197453Overview of the COVID-19 text mining tool interactive demonstration track in BioCreative VII.Database (Oxford)2022
36117290Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.J Med Chem2022
36393871What programs the size of animal cells?Front Cell Dev Biol2022
35239649The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.PLoS Biol2022
34731885Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.Blood Adv2022
35199530Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion.ACS Chem Biol2022
35482514The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor.Mol Biol Cell2022
36305789Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.J Cell Biol2022
35864841Head-to-tail cyclization of side chain-protected linear peptides to recapitulate genetically-encoded cyclized peptides.Pept Sci (Hoboken)2022
36197453Overview of the COVID-19 text mining tool interactive demonstration track in BioCreative VII.Database (Oxford)2022
36393871What programs the size of animal cells?Front Cell Dev Biol2022
36117290Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.J Med Chem2022
35239649The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.PLoS Biol2022
35199530Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion.ACS Chem Biol2022
33070389The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.Protein Sci2021
33579912PRMT5 inhibition disrupts splicing and stemness in glioblastoma.Nat Commun2021
33660365A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.Aging Cell2021
34316707A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.NAR Cancer2021
33070389The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.Protein Sci2021
33417871UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.Cell Stem Cell2021
34662547Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.J Mol Biol2021
34705497Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.Sci Adv2021
33660365A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.Aging Cell2021
33579912PRMT5 inhibition disrupts splicing and stemness in glioblastoma.Nat Commun2021
34705497Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.Sci Adv2021
34662547Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.J Mol Biol2021
34316707A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.NAR Cancer2021
33417871UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.Cell Stem Cell2021
32457299Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.Nat Commun2020
32409666Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.Nat Commun2020
32094149Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.Genetics2020
32457299Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.Nat Commun2020
32445698Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Cell2020
32709866Author Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery.Nat Commun2020
32755594Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.Mol Cell2020
32744610G1/S transcription factors assemble in increasing numbers of discrete clusters through G1 phase.J Cell Biol2020
33173868Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.bioRxiv2020
32785687Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality.J Cell Biol2020
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Collaborators

Bobby-Joe Breitkreutz
The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 27
Jasmin Coulombe-Huntington
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 22
Ashton Breitkreutz
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Co-authored papers 21
Lorrie Boucher
The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 20
Andrew Chatr-Aryamontri
Institute for Research in Immunology and Cancer (IRIC), University of Montreal
Co-authored papers 20
Chris Stark
The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 20
Kara Dolinski
Lewis-Sigler Institute for Integrative Genomics, Princeton University
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Rose Oughtred
Lewis-Sigler Institute for Integrative Genomics, Princeton University
Co-authored papers 16
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
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Teresa Reguly
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
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Andrew Winter
University of Edinburgh
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Jennifer Rust
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Brenda J Andrews
University of Toronto
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Christie S Chang
Co-authored papers 9
Gary D Bader
University of Toronto
Co-authored papers 9
Tony Pawson
Co-authored papers 8
Charles Boone
University of Toronto
Co-authored papers 7
Daniel Durocher
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 7
Gianni Cesareni
University of Rome 'Tor Vergata'
Co-authored papers 6
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 6
Alexey I Nesvizhskii
University of Michigan ann arbor
Co-authored papers 6
Matthias Peter
Institute of Biochemistry, ETH Zurich
Co-authored papers 6
Almer M van der Sloot
Institute for Research in Immunology and Cancer, Universite de Montreal
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Julie D Forman-Kay
Hospital for Sick Children
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Lea Harrington
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Anne Marinier
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Christopher W V Hogue
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Release 1.2