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Author Details

Daniel Schramek
University of Toronto
2005
59
34
Sami Nourreddine (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36763002In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target.Blood Cancer Discov2023
37922356Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes.Sci Adv2023
37258521In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer.Nat Commun2023
37059914Author Correction: The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.Nat Genet2023
36765696The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma.Cancers (Basel)2023
35235778CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities.Cell Rep2022
35439056Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins.Proc Natl Acad Sci U S A2022
36911295A CRISPR Path to Finding Vulnerabilities and Solving Drug Resistance: Targeting the Diverse Cancer Landscape and Its Ecosystem.Adv Genet (Hoboken)2022
36108220Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer.Cancer Discov2022
32820548An Adaptive Physiologically Based Pharmacokinetic-Driven Design to Investigate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of Molibresib (GSK525762) in Healthy Female Volunteers.J Clin Pharmacol2021
33603772Prevalence of the Brazilian <i>TP53</i> Founder c.1010G&gt;A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients?Front Genet2021
34686327Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas.Cell Rep2021
34270926Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.Cancer Cell2021
33372298AJUBA: A regulator of epidermal homeostasis and cancer.Exp Dermatol2021
32165588Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling.Science2020
33060361The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids.Science2020
33191932In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity.J Vis Exp2020
32944620<i>In vivo</i> CRISPR screens reveal potent driver mutations in head and neck cancers.Mol Cell Oncol2020
32709883Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Nat Commun2020
32589945Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins.Cell2020
32445698Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Cell2020
32142668Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas.Cancer Cell2020
30429576Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.Nat Genet2019
31784531CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci.Nat Commun2019
32337479Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations.JNCI Cancer Spectr2019
32337478Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions.JNCI Cancer Spectr2019
31267692Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.EMBO Mol Med2019
31133695AIF-regulated oxidative phosphorylation supports lung cancer development.Cell Res2019
30374066Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.Nat Genet2018
29925635Afatinib restrains K-RAS-driven lung tumorigenesis.Sci Transl Med2018
28002811Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer.Oncotarget2017
28077873Translation from unconventional 5' start sites drives tumour initiation.Nature2017
29039415CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.Nat Methods2017
27876675A Phase 1/1b Study Evaluating Trametinib Plus Docetaxel or Pemetrexed in Patients With Advanced Non-Small Cell Lung Cancer.J Thorac Oncol2017
26990290Activity of the oral mitogen-activated protein kinase kinase inhibitor trametinib in RAS-mutant relapsed or refractory myeloid malignancies.Cancer2016
27241552RANKL/RANK control Brca1 mutation- .Cell Res2016
27392790Phase 1 study to evaluate the effect of the MEK inhibitor trametinib on cardiac repolarization in patients with solid tumours.Cancer Chemother Pharmacol2016
25734337Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.Nat Commun2015
26590320ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas.Elife2015
24445999A dual role for autophagy in a murine model of lung cancer.Nat Commun2014
24675893MKK7 and ARF: new players in the DNA damage response scenery.Cell Cycle2014
24436421Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas.Science2014
22858987Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.Leukemia2013
23462470Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.Development2013
22863881A mouse model to identify cooperating signaling pathways in cancer.Nat Methods2012
21470874RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis.Trends Endocrinol Metab2011
22136931Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.Cell Stem Cell2011
21317887The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.Nat Genet2011
21445556RANKL/RANK-beyond bones.J Mol Med (Berl)2011
20074523Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate.Cell2010
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Collaborators

Richard Moriggl
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
Co-authored papers 4
Elaine Fuchs
The Rockefeller University
Co-authored papers 3
Rama Khokha
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Purna A Joshi
Princess Margaret Cancer Centre
Co-authored papers 3
Rod Bremner
University of Toronto
Co-authored papers 3
David W Cescon
Princess Margaret Cancer Centre
Co-authored papers 3
J??ri Reimand
Ontario Institute for Cancer Research
Co-authored papers 3
Nada Jabado
McGill University Health Centre (MUHC), Montreal Children's Hospital (MCH)
Co-authored papers 3
Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 3
Antonio C Wolff
Co-authored papers 2
Paul G Ekert
Co-authored papers 2
Karin Aumayr
Co-authored papers 2
Hartland W Jackson
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 2
James R Woodgett
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Philippe P Roux
IRIC - University of Montreal
Co-authored papers 2
Funda Meric-Bernstam
University of Texas MD Anderson Cancer Center
Co-authored papers 2
William D Foulkes
Segal Cancer Centre, Jewish General Hospital
Co-authored papers 2
Martin Widschwendter
European Translational Oncology Prevention and Screening (EUTOPS) Institute
Co-authored papers 2
Larissa A Korde
Clinical Investigations Branch, National Cancer Institute
Co-authored papers 2
Patrick Nitschke
Co-authored papers 2
Graham MacLeod
University of Toronto
Co-authored papers 2
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 2
Hamid Nikbakht
Co-authored papers 2
Meredith M Regan
Co-authored papers 2
Sharon Abish
McGill University
Co-authored papers 2
Lisa A Carey
Co-authored papers 2
Stephane Angers
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 2
Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 2
Henrik Molina
Co-authored papers 1
Genevi??ve Lavoie
Institute for Research in Immunology and Cancer (IRIC)
Co-authored papers 1
Release 1.2