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Author Details

Edward A Dennis
1966
344
93
PMIDPaper TitleJournal TitlePublished Year
37855672LIPID MAPS: update to databases and tools for the lipidomics community.Nucleic Acids Res2024
36990122Molecular basis of unique specificity and regulation of group VIA calcium-independent phospholipase A (PNPLA9) and its role in neurodegenerative diseases.2023
37842940Lipid storage disease in 4 sibling superb birds-of-paradise ().2023
34996868Lipoprotein-associated phospholipase A: A paradigm for allosteric regulation by membranes.Proceedings of the National Academy of Sciences of the United States of America2022
35745008Outtakes from My Journey through the World of LIPID MAPS.Molecules2022
35358512Allosteric regulation by membranes and hydrophobic subsites in phospholipase A enzymes determine their substrate specificity.Journal of Biological Chemistry2022
36315840Membrane Association Allosterically Regulates Phospholipase A Enzymes and Their Specificity.Accounts of Chemical Research2022
34634490Each phospholipase A type exhibits distinct selectivity toward sn-1 ester, alkyl ether, and vinyl ether phospholipids.Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids2022
35218041Bioactive lipids and metabolic syndrome-a symposium report.Annals of the New York Academy of Sciences2022
35204768-Acylated and -Alkylated 2-Aminobenzothiazoles Are Novel Agents That Suppress the Generation of Prostaglandin E.Biomolecules2022
34362906Quality control requirements for the correct annotation of lipidomics data.Nat Commun2021
34474084Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase As.Journal of Lipid Research2021
33003696Automated Annotation of Sphingolipids Including Accurate Identification of Hydroxylation Sites Using MS Data.Analytical Chemistry2020
32199750Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A inhibitors.Advances in Biological Regulation2020
32424181Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?Scientific Reports2020
322139112-Oxoester Phospholipase A Inhibitors with Enhanced Metabolic Stability.Biomolecules2020
33037133Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures.J Lipid Res2020
33196315Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications.Circ Genom Precis Med2020
32694525A global lipid map defines a network essential for Zika virus replication.Nat Commun2020
32581129PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection.Proc Natl Acad Sci U S A2020
30661990Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins.Cell Chem Biol2019
30622195LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training.Sci Signal2019
30615445Substrate-Specific Inhibition Constants for Phospholipase A Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics.Journal of Medicinal Chemistry2019
31460169Correction to "Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A (GIVA cPLA)".ACS Omega2019
30862696AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice.J Lipid Res2019
30905345Phospholipase A catalysis and lipid mediator lipidomics.Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids2019
30798607β-Lactones: A Novel Class of Ca-Independent Phospholipase A (Group VIA iPLA) Inhibitors with the Ability To Inhibit β-Cell Apoptosis.Journal of Medicinal Chemistry2019
30665457Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis.2019
29248300Review of four major distinct types of human phospholipase A.Advances in Biological Regulation2018
30115755MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines.J Lipid Res2018
30197994Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A (GIVA cPLA).ACS Omega2018
30323111Quantitative determination of esterified eicosanoids and related oxygenated metabolites after base hydrolysis.Journal of Lipid Research2018
30130298Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.Pain2018
29342349Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity.Journal of the American Chemical Society2018
29206462Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo.Journal of the American Chemical Society2018
280346462-Oxoamides based on dipeptides as selective calcium-independent phospholipase A inhibitors.Bioorganic and Medicinal Chemistry2017
287656062-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A.Scientific Reports2017
28986437Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.J Lipid Res2017
28630010Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis.2017
29404441The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.Hepatol Commun2017
27826094Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma.Journal of Allergy and Clinical Immunology2017
27555328Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease.Journal of Biological Chemistry2016
27063350Computational Modeling of Competitive Metabolism between Ͽ3- and Ͽ6-Polyunsaturated Fatty Acids in Inflammatory Macrophages.J Phys Chem B2016
27087127Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships.Journal of Medicinal Chemistry2016
27320659Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A.Bioorganic and Medicinal Chemistry2016
26774606Membrane and inhibitor interactions of intracellular phospholipases A2.Advances in Biological Regulation2016
275225782-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity.Bioorganic and Medicinal Chemistry2016
26031662Introduction to Thematic Review Series: Phospholipases: Central Role in Lipid Signaling and Disease.Journal of Lipid Research2015
25624474Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates.Proceedings of the National Academy of Sciences of the United States of America2015
25404585Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis.Journal of Lipid Research2015
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