Author details

Full Name

Thomas LaFramboise

Affiliation

ORCID

Career Start Year

2004

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36695636	A cloud-based resource for genome coordinate-based exploration and large-scale analysis of chromosome aberrations and gene fusions in cancer.	Genes Chromosomes Cancer	2023
37936209	Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential.		2023
37634012	Genomics of deletion 7 and 7q in myeloid neoplasm: from pathogenic culprits to potential synthetic lethal therapeutic targets.	Leukemia	2023
37013046	Metagenomic markings of myeloid malignancies.		2023
35085104	Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia.	Journal of Clinical Investigation	2022
35705525	Novel DNA Methylation Biomarker Panel for Detection of Esophageal Adenocarcinoma and High-Grade Dysplasia.	Clin Cancer Res	2022
35761024	Rare germline alterations of myeloperoxidase predispose to myeloid neoplasms.	Leukemia	2022
35941159	Adaptation to chronic ER stress enforces pancreatic Î²-cell plasticity.	Nat Commun	2022
35804437	SYSMut: decoding the functional significance of rare somatic mutations in cancer.	Briefings in Bioinformatics	2022
35870513	The Ephrin B2 Receptor Tyrosine Kinase Is a Regulator ofÂ Proto-oncogene MYC and Molecular Programs Central toÂ Barrett's Neoplasia.	Gastroenterology	2022
36266327	Significance of hereditary gene alterations for the pathogenesis of adult bone marrow failure versus myeloid neoplasia.	Leukemia	2022
35210415	Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes.	Nat Commun	2022
34748628	The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders.	Blood	2021
34236054	Clinical and basic implications of dynamic T cell receptor clonotyping in hematopoietic cell transplantation.	JCI insight	2021
33533264	Mitochondrial DNA Content Is Linked to Cardiovascular Disease Patient Phenotypes.	Journal of the American Heart Association	2021
34059054	Exonic variants undergoing allele-specific selection in cancers.	BMC Med Genomics	2021
34244611	Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression.	Leukemia	2021
33288657	Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury.	Cancer Res	2021
34638685	Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity.	International Journal of Molecular Sciences	2021
33004308	Complexities and pitfalls in analyzing and interpreting mitochondrial DNA content in human cancer.	Journal of Genetics and Genomics	2020
31911633	Rare germline variant contributions to myeloid malignancy susceptibility.	Leukemia	2020
33038980	Myeloid neoplasms with germline predisposition: Practical considerations and complications in the search for new susceptibility loci.	Best Practice and Research in Clinical Haematology	2020
30891747	Impact of germline CTC1 alterations on telomere length in acquired bone marrow failure.	British Journal of Haematology	2019
31772163	Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes.	Nat Commun	2019
30075297	Mitochondrial genomics in the cancer cell line encyclopedia and a scoring method to effectively pair cell lines for cytoplasmic hybridization.	Mitochondrion	2019
31510921	CytoConverter: a web-based tool to convert karyotypes to genomic coordinates.	BMC Bioinformatics	2019
29795413	Consequences of mutant TET2 on clonality and subclonal hierarchy.	Leukemia	2018
30348202	The DNMT1-associated lincRNA DACOR1 reprograms genome-wide DNA methylation in colon cancer.	Clinical Epigenetics	2018
30571798	Correction: A 32 kb Critical Region Excluding Y402H in CFH Mediates Risk for Age-Related Macular Degeneration.	PLoS One	2018
30322869	Germline loss-of-function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes.	Blood	2018
29343623	Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus.	Sci Transl Med	2018
29743621	Colon Cancer-Upregulated Long Non-Coding RNA lincDUSP Regulates Cell Cycle Genes and Potentiates Resistance to Apoptosis.	Sci Rep	2018
29684080	Unexpected cancer-predisposition gene variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients without underlying germline PTEN mutations.	PLoS Genetics	2018
28113734	Visually Meaningful Histopathological Features for Automatic Grading of Prostate Cancer.	IEEE J Biomed Health Inform	2017
28555081	Genomic determinants of chronic myelomonocytic leukemia.	Leukemia	2017
28368421	Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR<sup>mt</sup> to promote metastasis.	Oncogene	2017
28475717	Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection.	Human Molecular Genetics	2017
29072135	Detection and quantification of mitochondrial DNA deletions from next-generation sequence data.	BMC Bioinformatics	2017
27362987	Pluribus-Exploring the Limits of Error Correction Using a Suffix Tree.	IEEE/ACM Transactions on Computational Biology and Bioinformatics	2017
28011713	Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma.	Hum Mol Genet	2017
28255022	Molecular features of early onset adult myelodysplastic syndrome.	Haematologica	2017
27992414	Dynamics of clonal evolution in myelodysplastic syndromes.	Nat Genet	2017
28031539	Recurrent genetic defects on chromosome 5q in myeloid neoplasms.	Oncotarget	2017
27542211	Phase I/II study of azacitidine and capecitabine/oxaliplatin (CAPOX) in refractory CIMP-high metastatic colorectal cancer: evaluation of circulating methylated vimentin.	Oncotarget	2016
27243821	Correction: PCR-Free Enrichment of Mitochondrial DNA from Human Blood and Cell Lines for High Quality Next-Generation DNA Sequencing.	PLoS One	2016
27321283	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.	Nat Commun	2016
26488301	PCR-Free Enrichment of Mitochondrial DNA from Human Blood and Cell Lines for High Quality Next-Generation DNA Sequencing.	PLoS One	2015
25694510	Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer.	Endocr Relat Cancer	2015
26453823	Whole-exome sequencing enhances prognostic classification of myeloid malignancies.	J Biomed Inform	2015
24597945	DB2: a probabilistic approach for accurate detection of tandem duplication breakpoints using paired-end reads.	BMC Genomics	2014