Author details

Full Name

Wen-Ning Zhao

Affiliation

ORCID

Career Start Year

1996

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36039764	Chemically targeting the redox switch in AP1 transcription factor Î¿FOSB.	Nucleic Acids Research	2022
30990190	Deep Learning Benchmarks on L1000 Gene Expression Data.	IEEE/ACM Trans Comput Biol Bioinform	2020
32094324	Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion.	Transl Psychiatry	2020
31202891	Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA).	Mol Cell Neurosci	2019
31783699	An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration.	Cells	2019
29897904	Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.	PLoS One	2018
30510233	High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.	Nature Communications	2018
29932631	Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory.	ACS Chem Neurosci	2018
30046097	Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling.	Translational Psychiatry	2018
29195078	A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.	Cell	2017
28500272	Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.	Proc Natl Acad Sci U S A	2017
28979942	HDAC6 Brain Mapping with [F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination.	ACS Central Science	2017
28712747	Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.	Cell Chemical Biology	2017
28879201	WNT/Î²-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene .		2017
29162813	Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability.	Nat Commun	2017
27377864	Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.	Bioorganic and Medicinal Chemistry	2016
26804233	Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.	Bioorg Med Chem Lett	2016
26219339	A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas.	Oncotarget	2015
25878248	Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function.	J Biol Chem	2015
25642316	Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers.	Chem Sci	2015
23967191	A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.	PLoS ONE	2013
22771460	Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.	Neuropharmacology	2013
22923789	A high-throughput screen for Wnt/Î²-catenin signaling pathway modulators in human iPSC-derived neural progenitors.	J Biomol Screen	2012
21685895	A screen for regulators of survival of motor neuron protein levels.	Nature Chemical Biology	2011
21874153	Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.	ACS Med Chem Lett	2010
21067169	An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.	Journal of the American Chemical Society	2010
17310242	CIPC is a mammalian circadian clock protein without invertebrate homologues.	Nature Cell Biology	2007
17046689	Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.	Neuron	2006
14682243	Labeling of three different mouse ES cell lines with the green fluorescent protein.		2003
12621548	[RNA interference in three ES cell lines from different mouse strains].	Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)	2003
9268311	Affinity purification and kinetic analysis of mutant forms of yeast NAD+-specific isocitrate dehydrogenase.	Journal of Biological Chemistry	1997
8626605	Assembly and function of a cytosolic form of NADH-specific isocitrate dehydrogenase in yeast.	Journal of Biological Chemistry	1996