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Author Details

Kurt W??thrich
iHuman Institute, ShanghaiTech University
1964
592
119
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38072902<sup>19</sup>F-NMR studies of the impact of different detergents and nanodiscs on the A<sub>2A</sub> adenosine receptor.J Biomol NMR2024
37332600Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR.iScience2023
37513291Two-Dimensional NMR Spectroscopy of the G Protein-Coupled Receptor A<sub>2A</sub>AR in Lipid Nanodiscs.Molecules2023
37051308Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by <sup>19</sup>F-NMR and cryo-electron microscopy.MedComm (2020)2023
37276462Adenosine A<sub>2A</sub> Receptor (A<sub>2A</sub>AR) Ligand Screening Using the <sup>19</sup>F-NMR Probe FPPA.J Am Chem Soc2023
37073622Solvent accessibility of a GPCR transmembrane domain probed by in-membrane chemical modification (IMCM).FEBS Lett2023
36017890GPCR structural characterization by NMR spectroscopy in solution.Acta Biochim Biophys Sin (Shanghai)2022
35377814GPCR large-amplitude dynamics by <sup>19</sup>F-NMR of aprepitant bound to the neurokinin 1 receptor.Proc Natl Acad Sci U S A2022
35566006G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling.Molecules2022
35390714Dual-acting antitumor agents targeting the A<sub>2A</sub> adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives.Eur J Med Chem2022
32975902OCRE Domains of Splicing Factors RBM5 and RBM10: Tyrosine Ring-Flip Frequencies Determined by Integrated Use of <sup>1</sup> H NMR Spectroscopy and Molecular Dynamics Simulations.Chembiochem2021
34511337Richard R. Ernst (1933-2021) - A life of NMR, classical music and Tibetan art.J Magn Reson2021
34391647Brownian motion, spin diffusion and protein structure determination in solution.J Magn Reson2021
33369025Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for <sup>19</sup> F-NMR studies in solution.FEBS J2021
33238145A<sub>2A</sub> Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch.Structure2021
32911819Tumor Immunotherapy Using A<sub>2A</sub> Adenosine Receptor Antagonists.Pharmaceuticals (Basel)2020
31978323Biased Signaling of the G-Protein-Coupled Receptor β<sub>2</sub>AR Is Governed by Conformational Exchange Kinetics.Structure2020
30410121GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures.Nat Rev Drug Discov2019
31368214Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins.Chemistry2019
30733446Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.Nat Commun2019
29290469Allosteric Coupling of Drug Binding and Intracellular Signaling in the A<sub>2A</sub> Adenosine Receptor.Cell2018
30185622Molecular interactions connecting the function of the serine-arginine-rich protein SRSF1 to protein phosphatase 1.J Biol Chem2018
29874058Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor.J Am Chem Soc2018
30463958A<sub>2A</sub> adenosine receptor functional states characterized by <sup>19</sup>F-NMR.Proc Natl Acad Sci U S A2018
29450990Splicing Site Recognition by Synergy of Three Domains in Splicing Factor RBM10.Biochemistry2018
28827331Prion protein <i>β</i>2-<i>α</i>2 loop conformational landscape.Proc Natl Acad Sci U S A2017
28207746Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.PLoS One2017
28508109Solvent-accessibility of discrete residue positions in the polypeptide hormone glucagon by <sup>19</sup>F-NMR observation of 4-fluorophenylalanine.J Biomol NMR2017
27050129UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex.Acta Crystallogr D Struct Biol2016
27839952β<sub>2</sub>-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop.Structure2016
27396829Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA Binding.Structure2016
27240587Ring current shifts in (19)F-NMR of membrane proteins.J Biomol NMR2016
27237473The formation, function and regulation of amyloids: insights from structural biology.J Intern Med2016
27154589NMR in structural genomics to increase structural coverage of the protein universe: Delivered by Prof. Kurt Wüthrich on 7 July 2013 at the 38th FEBS Congress in St. Petersburg, Russia.FEBS J2016
26749007NMR reveals structural rearrangements associated to substrate insertion in nucleotide-adding enzymes.Protein Sci2016
27091468Directional Phosphorylation and Nuclear Transport of the Splicing Factor SRSF1 Is Regulated by an RNA Recognition Motif.J Mol Biol2016
26712279Nuclear Magnetic Resonance Structure of a Novel Globular Domain in RBM10 Containing OCRE, the Octamer Repeat Sequence Motif.Structure2016
26829219Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome.J Mol Biol2016
27081926The acidic domain is a unique structural feature of the splicing factor SYNCRIP.Protein Sci2016
25428764APSY-NMR for protein backbone assignment in high-throughput structural biology.J Biomol NMR2015
26545333In-Membrane Chemical Modification (IMCM) for Site-Specific Chromophore Labeling of GPCRs.Angew Chem Int Ed Engl2015
26372966NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor.Proc Natl Acad Sci U S A2015
26578769Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.Proc Natl Acad Sci U S A2015
27077076Micro-scale NMR Experiments for Monitoring the Optimization of Membrane Protein Solutions for Structural Biology.Bio Protoc2015
26177955Cofactor-induced reversible folding of Flavodoxin-4 from Lactobacillus acidophilus.Protein Sci2015
26227870Non-Uniform Sampling and J-UNIO Automation for Efficient Protein NMR Structure Determination.Chemistry2015
25924193Q&amp;A: Science regeneration.Nature2015
25430057NMR structure determination of the protein NP_344798.1 as the first representative of Pfam PF06042.J Biomol NMR2015
25428766J-UNIO protocol used for NMR structure determination of the 206-residue protein NP_346487.1 from Streptococcus pneumoniae TIGR4.J Biomol NMR2015
24431459Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC.J Neurosci2014
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Collaborators

Roland Riek
ETH Zurich
Co-authored papers 27
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 20
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 14
Sebastian Hiller
University of Basel
Co-authored papers 11
Marc-Andr?? Elsliger
Joint Center for Structural Genomics
Co-authored papers 9
Robert Kaptein
Utrecht University
Co-authored papers 7
Peter Kuhn
University of Tubingen
Co-authored papers 6
David Neuhaus
Medical Research Council - Laboratory of Molecular Biology
Co-authored papers 6
Walter J Chazin
and Center for Structural Biology, Vanderbilt University
Co-authored papers 6
Scott A Lesley
Merck & Co., Inc.
Co-authored papers 5
Harold A Scheraga
Co-authored papers 5
Ad Bax
National Institutes of Health
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Adam Godzik
University of California Riverside
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Francesc X Avil??s
Clinical Institute of Hematology and Oncology, Hospital Clinic Barcelona
Co-authored papers 4
John L Markley
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Lawrence Berkeley National Laboratory
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Ashley M Deacon
Accelero Biostructures Inc., USA XPose Therapeutics Inc.
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Gaetano T Montelione
Rensselaer Polytechnic Institute
Co-authored papers 4
Mike P Williamson
The University of Sheffield
Co-authored papers 4
Herbert L Axelrod
Joint Center for Structural Genomics
Co-authored papers 3
Ralph A Bradshaw
Co-authored papers 3
Edouard C Nice
Monash University
Co-authored papers 3
Volker D??tsch
Institute for Biophysical Chemistry, Goethe-University
Co-authored papers 3
Brandon E Aubol
University of California San Diego
Co-authored papers 2
Udo Seedorf
Co-authored papers 2
Rolf Boelens
Utrecht University
Co-authored papers 2
Heath E Klock
Merck & Co., Inc.
Co-authored papers 2
Zhan-Guo Gao
National Institutes of Health
Co-authored papers 2
Lukasz Jaroszewski
University of California Riverside School of Medicine
Co-authored papers 2
Kenneth A Jacobson
National Institutes of Health
Co-authored papers 2
Release 1.2