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Author Details

Stephen Fawell
Oncology R&D
1984
73
40
PMIDPaper TitleJournal TitlePublished Year
36912782Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners.Mol Cancer Ther2023
35929986Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper.Clin Cancer Res2022
32692162Challenges and Opportunities in Cancer Drug Resistance.Chem Rev2021
33718951How a new drug is born.Eur Heart J2021
33785652Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition.Mol Cancer Ther2021
33495510Design and optimisation of dendrimer-conjugated Bcl-2/x<sub>L</sub> inhibitor, AZD0466, with improved therapeutic index for cancer therapy.Commun Biol2021
34570508Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.J Med Chem2021
33273059AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in <i>KRAS</i>-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib.Mol Cancer Ther2021
33259592Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas.Blood2021
32297743Discovery of (2<i>R</i>)-<i>N</i>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<i>H</i>-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.J Med Chem2020
31786184EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.Cell Chem Biol2020
31699827AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells.Clin Cancer Res2020
32717371Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.Bioorg Med Chem Lett2020
32943458<i>STAT3</i> Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti-PD-L1.Clin Cancer Res2020
32910656Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.J Med Chem2020
32627965Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens.Mol Syst Biol2020
32988967AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.Clin Cancer Res2020
32727810Small molecule AZD4635 inhibitor of A<sub>2A</sub>R signaling rescues immune cell function including CD103<sup>+</sup> dendritic cells enhancing anti-tumor immunity.J Immunother Cancer2020
32350132Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.Sci Transl Med2020
31209238Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.Nat Commun2019
31699977AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.Nat Commun2019
29533782BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.Cancer Cell2018
30036377BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors.PLoS One2018
30297535Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.Cancer Res2018
30335946Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.ACS Chem Biol2018
29636547BRD4 facilitates replication stress-induced DNA damage response.Oncogene2018
29245897Comparative analysis of primary <i>versus</i> relapse/refractory DLBCL identifies shifts in mutation spectrum.Oncotarget2017
26832798Dissecting Therapeutic Resistance to ERK Inhibition.Mol Cancer Ther2016
27472462Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations.Oncotarget2016
27573426AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.Mol Cancer Ther2016
25537515Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers.Oncotarget2015
25779944The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models.Clin Cancer Res2015
25104330Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.Cancer Discov2014
25289887MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.PLoS One2014
23699655Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy.Mol Cancer Ther2013
23614898Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.Cancer Discov2013
23323157Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors.Transl Oncol2012
20127862Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: Defining molecular mechanisms of resistance.Int J Cancer2010
20713706Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.Proc Natl Acad Sci U S A2010
19759537Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.Nature2009
18199553Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.Cancer Res2008
18089776A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling.Cancer Res2007
17018619Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy.Cancer Res2006
16288033Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer.Cancer Res2005
11162308Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver.Mol Ther2001
11435460Systemic IFN-beta gene therapy results in long-term survival in mice with established colorectal liver metastases.J Clin Invest2001
9826714Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice.Proc Natl Acad Sci U S A1998
9395478Fibronectin type III repeats mediate RGD-independent adhesion and signaling through activated beta1 integrins.J Biol Chem1997
8647938The alpha1beta1 integrin is expressed during neointima formation in rat arteries and mediates collagen matrix reorganization.J Clin Invest1996
8970166Tat-mediated protein delivery can facilitate MHC class I presentation of antigens.Mol Biotechnol1996
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Collaborators

Repare Therapeutics Inc.
Co-authored papers 12
Wellcome Sanger Institute
Co-authored papers 4
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Co-authored papers 4
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Co-authored papers 4
Present Address: Tempus Labs Inc.
Co-authored papers 4
Oncology R&D
Co-authored papers 4
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Co-authored papers 4
Oncology R&D
Co-authored papers 4
Oncology R&D
Co-authored papers 4
Knight Cancer Institute, Oregon Health and Sciences University
Co-authored papers 4
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Co-authored papers 3
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Co-authored papers 3
Preclinical and Translational Sciences, Inc.
Co-authored papers 3
Oncology R&D
Co-authored papers 3
Wellcome Sanger Institute
Co-authored papers 3
Wellcome Sanger Institute
Co-authored papers 3
Co-authored papers 3
Oncology R&D
Co-authored papers 3
Oncology R&D
Co-authored papers 3
School of Clinical Sciences at Monash Health, Monash University
Co-authored papers 2
The University of Melbourne
Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
Co-authored papers 2
Oncology R&D
Co-authored papers 2
Co-authored papers 2
ALS Therapy Development Institute
Co-authored papers 2
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Oncology R&D
Co-authored papers 2