Author details

Full Name

Cyrus Chothia

Affiliation

ORCID

Career Start Year

1968

Papers

158

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
25348407	Genome3D: exploiting structure to help users understand their sequences.	Nucleic Acids Res	2015
25754991	Investigating Protein Structure and Evolution with SCOP2.	Current Protocols in Bioinformatics	2015
24293656	SCOP2 prototype: a new approach to protein structure mining.	Nucleic Acids Research	2014
23203986	Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains.	Nucleic Acids Res	2013
22566652	Evolution of oligomeric state through geometric coupling of protein interfaces.	Proc Natl Acad Sci U S A	2012
21062816	SUPERFAMILY 1.75 including a domain-centric gene ontology method.	Nucleic Acids Res	2011
20456943	Ubiquitin--molecular mechanisms for recognition of different structures.	Curr Opin Struct Biol	2010
19272021	Genomic and structural aspects of protein evolution.	Biochem J	2009
19036790	SUPERFAMILY--sophisticated comparative genomics, data mining, visualization and phylogeny.	Nucleic Acids Res	2009
18000004	Data growth and its impact on the SCOP database: new developments.	Nucleic Acids Res	2008
17098927	The SUPERFAMILY database in 2007: families and functions.	Nucleic Acids Res	2007
17223535	The generation of new protein functions by the combination of domains.	Structure	2007
17540730	The selection of acceptable protein mutations.	Proc Natl Acad Sci U S A	2007
17112313	3D complex: a structural classification of protein complexes.	PLoS Comput Biol	2006
16698554	Divergence of interdomain geometry in two-domain proteins.	Structure	2006
16733546	Protein family expansions and biological complexity.	PLoS Comput Biol	2006
15093836	Structure, function and evolution of multidomain proteins.	Curr Opin Struct Biol	2004
15274913	The linked conservation of structure and function in a family of high diversity: the monomeric cupredoxins.	Structure	2004
15313612	VH gene segments in the mouse and human genomes.	Journal of Molecular Biology	2004
14681402	The SUPERFAMILY database in 2004: additions and improvements.	Nucleic Acids Res	2004
14681400	SCOP database in 2004: refinements integrate structure and sequence family data.	Nucleic Acids Res	2004
14576296	Exegesis: a procedure to improve gene predictions and its use to find immunoglobulin superfamily proteins in the human and mouse genomes.	Nucleic Acids Research	2003
14623821	The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity.	Development	2003
12805536	Evolution of the protein repertoire.	Science	2003
12466851	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Nature	2002
12045145	Comparison of the small molecule metabolic enzymes of Escherichia coli and Saccharomyces cerevisiae.	Genome Res	2002
12215425	Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes.	Journal of Molecular Biology	2002
11812158	The geometry of domain combination in proteins.	Journal of Molecular Biology	2002
11752311	SCOP database in 2002: refinements accommodate structural genomics.	Nucleic Acids Res	2002
11752312	SUPERFAMILY: HMMs representing all proteins of known structure. SCOP sequence searches, alignments and genome assignments.	Nucleic Acids Res	2002
11162110	Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster.	Journal of Molecular Biology	2001
11406387	Determination of protein function, evolution and interactions by structural genomics.	Curr Opin Struct Biol	2001
11711174	Small-molecule metabolism: an enzyme mosaic.	Trends Biotechnol	2001
11518524	The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli.	J Mol Biol	2001
11697912	Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure.	J Mol Biol	2001
11514671	The sequence determinants of cadherin molecules.	Protein Science	2001
10842730	Sequence search algorithm assessment and testing toolkit (SAT).	Bioinformatics	2000
11153093	Geometric invariant core for the CL and CH1 domains of immunoglobulin molecules.	J Comput Biol	2000
10698639	Immunoglobulin superfamily proteins in Caenorhabditis elegans.	J Mol Biol	2000
10623553	Conservation of folding and stability within a protein family: the tyrosine corner as an evolutionary cul-de-sac.	Journal of Molecular Biology	2000
10871268	RSDB: representative protein sequence databases have high information content.	Bioinformatics	2000
10656805	Canonical structures for the hypervariable regions of T cell alphabeta receptors.	J Mol Biol	2000
10592240	SCOP: a structural classification of proteins database.	Nucleic Acids Res	2000
10842732	Fast assignment of protein structures to sequences using the intermediate sequence library PDB-ISL.	Bioinformatics	2000
10523185	Perspectives: signal transduction. Proteins in motion.	Science	1999
9847194	SCOP: a Structural Classification of Proteins database.	Nucleic Acids Res	1999
9925793	The atomic structure of protein-protein recognition sites.	Journal of Molecular Biology	1999
9889186	The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.	EMBO J	1999
10388571	The packing density in proteins: standard radii and volumes.	J Mol Biol	1999
10361097	Advances in structural genomics.	Curr Opin Struct Biol	1999