Author details

Full Name

Leanne E Felkin

Affiliation

ORCID

Career Start Year

2001

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35147166	Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.	Biochemical Journal	2022
35926050	Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.	Science	2022
34108253	Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.	Science Translational Medicine	2021
31983221	Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy.	Circulation	2020
31155234	The Translational Landscape of the Human Heart.	Cell	2019
29892087	A gene-centric strategy for identifying disease-causing rare variants in dilated cardiomyopathy.	Genet Med	2019
31284728	Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins.	Circulation	2019
30696458	Quantitative approaches to variant classification increase the yield and precision of genetic testing in Mendelian diseases: the case of hypertrophic cardiomyopathy.	Genome Med	2019
31501434	Author Correction: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.	Nat Commun	2019
31399586	WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.	Nat Commun	2019
28082330	Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes.	Eur Heart J	2017
28903782	Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.	Genome Biol	2017
27746127	The Calcineurin Variant CnAÎ²1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation.	Cell Chem Biol	2016
27437901	Recovery of Cardiac Function in Cardiomyopathy Caused by Titin Truncation.	JAMA Cardiology	2016
26175529	ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.	Circ Cardiovasc Genet	2015
25589632	Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.	Sci Transl Med	2015
24879379	Heat shock protein-27 delays acute rejection after cardiac transplantation: an experimental model.	Transplantation	2014
25516437	Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure.	Journal of the American Heart Association	2014
22915069	Follistatin-like 3 mediates paracrine fibroblast activation by cardiomyocytes.	J Cardiovasc Transl Res	2012
21979051	Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.	Nature	2011
21424859	Reverse remodelling and recovery from heart failure are associated with complex patterns of gene expression.	J Cardiovasc Transl Res	2011
21632490	Calcineurin splicing variant calcineurin AÎ²1 improves cardiac function after myocardial infarction without inducing hypertrophy.	Circulation	2011
21799151	Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.	Circ Res	2011
20577844	Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1.	Journal of Cardiovascular Translational Research	2010
20559987	A gene expression profile of the myocardial response to clenbuterol.	Journal of Cardiovascular Translational Research	2009
19201335	Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support.	Journal of Heart and Lung Transplantation	2009
19376125	Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice.	Journal of Molecular and Cellular Cardiology	2009
18728781	Choice of cell-delivery route for skeletal myoblast transplantation for treating post-infarction chronic heart failure in rat.	PLoS ONE	2008
18617621	Expression of follistatin-related genes is altered in heart failure.	Endocrinology	2008
18413147	Heterogeneic nature of adult cardiac side population cells.	Biochemical and Biophysical Research Communications	2008
18178572	Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure.	Cardiovascular Research	2008
17126612	Correlation between vascular responsivensss and expression of novel transcripts of the ETA-receptor in human vascular tissue.	Vascular Pharmacology	2007
17438152	Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model.	Circulation	2007
17132651	Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy.	Eur Heart J	2007
16790858	Real-time quantitative polymerase chain reaction in cardiac transplant research.	Methods in Molecular Biology	2006
17178334	A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support.	Journal of Heart and Lung Transplantation	2006
16820567	Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis.	Circulation	2006
15808844	Phenylephrine requires the TATA box to activate transcription of GLUT1 in neonatal rat cardiac myocytes.	Journal of Molecular and Cellular Cardiology	2005
16159864	Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy.	Circulation	2005
15809685	Expression of human membrane skeleton protein genes for protein 4.1 and betaIISigma2-spectrin assayed by real-time RT-PCR.	Cell Mol Biol Lett	2005
15753848	Sequential expression of three known protective genes in cardiac biopsies after transplantation.	Transplantation	2005
14761771	Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices.	Journal of Heart and Lung Transplantation	2004
27520668	The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart.	Molecular and Cellular Biochemistry	2004
15524170	The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart.	Molecular and Cellular Biochemistry	2004
12873541	Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure.	Journal of Heart and Lung Transplantation	2003
11568062	Quantitative myocardial cytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices.	Circulation	2001