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Author Details

Denise D Belsham
University of Toronto, 1 Kings College Circle
1988
148
45
PMIDPaper TitleJournal TitlePublished Year
37011479Phenylbutyric acid robustly increases Npy mRNA expression in hypothalamic neurons by increasing H3K9/14 acetylation at the Npy promoter.Biochem Biophys Res Commun2023
37761913Bisphenol A Alters the Levels of miRNAs That Directly and/or Indirectly Target Neuropeptide Y in Murine Hypothalamic Neurons.Genes (Basel)2023
37054963Palmitate alters miRNA content of small extracellular vesicles secreted from NPY/AgRP-expressing hypothalamic neurons.Brain Res2023
37453100Promise and Perils of MicroRNA Discovery Research: Working Toward Quality Over Quantity.Endocrinology2023
37044089Immortal orexin cell transplants restore motor-arousal synchrony during cataplexy.Curr Biol2023
37208960Palmitate alters miR-2137 and miR-503-5p to induce orexigenic Npy in hypothalamic neuronal cell models: Rescue by oleate and docosahexaenoic acid.J Neuroendocrinol2023
34624438Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models.Mol Cell Endocrinol2022
35569583Bisphenol S induces Agrp expression through GPER1 activation and alters transcription factor expression in immortalized hypothalamic neurons: A mechanism distinct from BPA-induced upregulation.Mol Cell Endocrinol2022
36467544Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, <i>in vitro</i>: A potential antagonist of corticotropin-releasing factor (CRF).Biochem Biophys Rep2022
35981630Oleate restores altered autophagic flux to rescue palmitate lipotoxicity in hypothalamic neurons.Mol Cell Endocrinol2022
36083576Neuroendocrine microRNAs linked to energy homeostasis: future therapeutic potential.Pharmacol Rep2022
34919671Hypothalamic miR-1983 Targets Insulin Receptor β and the Insulin-mediated miR-1983 Increase Is Blocked by Metformin.Endocrinology2022
34763011Spexin: Its role, regulation, and therapeutic potential in the hypothalamus.Pharmacol Ther2022
32575098Bisphenol A Induces Agrp Gene Expression in Hypothalamic Neurons through a Mechanism Involving ATF3.Neuroendocrinology2021
35059547The Regulation of Phoenixin: A Fascinating Multidimensional Peptide.J Endocr Soc2021
34482548Palmitate-mediated induction of neuropeptide Y expression occurs through intracellular metabolites and not direct exposure to proinflammatory cytokines.J Neurochem2021
34831343Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus.Cells2021
34327275Immunofluorescence of GFAP and TNF-α in the Mouse Hypothalamus.Bio Protoc2021
32114021Analysis of Western diet, palmitate and BMAL1 regulation of neuropeptide Y expression in the murine hypothalamus and BMAL1 knockout cell models.Mol Cell Endocrinol2020
31730796Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons.Neuroscience2020
33227171Insulin signalling in hypothalamic neurones.J Neuroendocrinol2020
33080217Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty.Cell Metab2020
33040385Acute effects of fatty acids on autophagy in NPY neurones.J Neuroendocrinol2020
32595600NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons.Front Endocrinol (Lausanne)2020
32960947BPA Differentially Regulates NPY Expression in Hypothalamic Neurons Through a Mechanism Involving Oxidative Stress.Endocrinology2020
32841709Palmitate differentially regulates Spexin, and its receptors Galr2 and Galr3, in GnRH neurons through mechanisms involving PKC, MAPKs, and TLR4.Mol Cell Endocrinol2020
32894767Hope in Hopeless Times: Gearing Up to Fight the Obesity Pandemic.Endocrinology2020
32750397Hypothalamic reproductive neurons communicate through signal transduction to control reproduction.Mol Cell Endocrinol2020
30500912Bisphenol A Alters Bmal1, Per2, and Rev-Erba mRNA and Requires Bmal1 to Increase Neuropeptide Y Expression in Hypothalamic Neurons.Endocrinology2019
31697675Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3.PLoS Biol2019
30149043Bisphenol A induces Pomc gene expression through neuroinflammatory and PPARγ nuclear receptor-mediated mechanisms in POMC-expressing hypothalamic neuronal models.Mol Cell Endocrinol2019
300628333-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) prevents high fat diet-induced insulin resistance via maintenance of hepatic lipid homeostasis.Diabetes Obes Metab2019
31404896Direct effects of antipsychotic drugs on insulin, energy sensing and inflammatory pathways in hypothalamic mouse neurons.Psychoneuroendocrinology2019
30802709Antipsychotics differentially regulate insulin, energy sensing, and inflammation pathways in hypothalamic rat neurons.Psychoneuroendocrinology2019
30716364Regulation of Gpr173 expression, a putative phoenixin receptor, by saturated fatty acid palmitate and endocrine-disrupting chemical bisphenol A through a p38-mediated mechanism in immortalized hypothalamic neurons.Mol Cell Endocrinol2019
30582235Tumour necrosis factor α induces neuroinflammation and insulin resistance in immortalised hypothalamic neurones through independent pathways.J Neuroendocrinol2019
29180108Palmitate induces neuroinflammation, ER stress, and Pomc mRNA expression in hypothalamic mHypoA-POMC/GFP neurons through novel mechanisms that are prevented by oleate.Mol Cell Endocrinol2018
30524225Phoenixin Expression Is Regulated by the Fatty Acids Palmitate, Docosahexaenoic Acid and Oleate, and the Endocrine Disrupting Chemical Bisphenol A in Immortalized Hypothalamic Neurons.Front Neurosci2018
30352432Palmitate Induces an Anti-Inflammatory Response in Immortalized Microglial BV-2 and IMG Cell Lines that Decreases TNFα Levels in mHypoE-46 Hypothalamic Neurons in Co-Culture.Neuroendocrinology2018
29671415Phoenixin: uncovering its receptor, signaling and functions.Acta Pharmacol Sin2018
29631363Role of the saturated fatty acid palmitate in the interconnected hypothalamic control of energy homeostasis and biological rhythms.Am J Physiol Endocrinol Metab2018
27773938High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons.Int J Obes (Lond)2017
26784927Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons.PLoS One2016
27893782Beneficial Effects of Metformin and/or Salicylate on Palmitate- or TNFα-Induced Neuroinflammatory Marker and Neuropeptide Gene Regulation in Immortalized NPY/AgRP Neurons.PLoS One2016
27863560Signaling in the hypothalamus: New concepts.Mol Cell Endocrinol2016
27306829Nutrient-sensing mechanisms in hypothalamic cell models: neuropeptide regulation and neuroinflammation in male- and female-derived cell lines.Am J Physiol Regul Integr Comp Physiol2016
27208620Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia.Mol Cell Endocrinol2016
27268078Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173.Mol Endocrinol2016
26930171Nitric Oxide Exerts Basal and Insulin-Dependent Anorexigenic Actions in POMC Hypothalamic Neurons.Mol Endocrinol2016
26923440Induction of Gnrh mRNA expression by the Ï¿-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP.Mol Cell Endocrinol2016
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Collaborators

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Co-authored papers 2
Center for Neurodegenerative Science, Van Andel Research Institute
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Ontario Institute for Cancer Research
Co-authored papers 1
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Tokai University School of Medicine
Co-authored papers 1
University of Guelph
Co-authored papers 1
Neurochemical Research Unit, University of Alberta
Co-authored papers 1
Children's Hospital of Eastern Ontario Research Institute
Co-authored papers 1
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Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
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