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Author Details

Akhil B Vaidya
Center for Molecular Parasitology, Drexel University College of Medicine
1971
108
43
PMIDPaper TitleJournal TitlePublished Year
36788578Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors.Malar J2023
37556486Inducing indigestion in malaria parasites: Genetic manipulations of a proton pump.Proc Natl Acad Sci U S A2023
37406344Unique Properties of Apicomplexan Mitochondria.Annu Rev Microbiol2023
35196803Dramatic Consequences of Reducing Erythrocyte Membrane Cholesterol on Plasmodium falciparum.Microbiol Spectr2022
35984838Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum.PLoS One2022
35064153Metabolic adjustments of blood-stage Plasmodium falciparum in response to sublethal pyrazoleamide exposure.Sci Rep2022
33361312Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum.Antimicrob Agents Chemother2021
34339273Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.Antimicrob Agents Chemother2021
30638365Diverse Chemical Compounds Target Plasmodium falciparum Plasma Membrane Lipid Homeostasis.ACS Infect Dis2019
30888318<i>Plasmodium</i> Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis.Elife2019
30964863Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages.PLoS One2019
29626096The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion in <i>Plasmodium falciparum</i>.J Biol Chem2018
29902252Reflections on an inflection: From virology to parasitology guided by POLARIS.PLoS Pathog2018
28927276Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.ACS Infect Dis2017
28708996Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.Cell2017
27015086Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p.PLoS One2016
27799215Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity.Antimicrob Agents Chemother2016
27270285Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.Antimicrob Agents Chemother2016
27227970Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum.PLoS Pathog2016
25605352Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.Antimicrob Agents Chemother2015
26711768Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050.Antimicrob Agents Chemother2015
26124159ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.Antimicrob Agents Chemother2015
25843709Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle.Cell Rep2015
25918204Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.Am J Trop Med Hyg2015
25662767Host erythrocyte environment influences the localization of exported protein 2, an essential component of the Plasmodium translocon.Eukaryot Cell2015
24720377Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.J Med Chem2014
25422853Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.Nat Commun2014
25295216Antirelapse Efficacy of Various Primaquine Regimens for Plasmodium vivax.Malar Res Treat2014
25352601The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.J Biol Chem2014
23515079Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med2013
23927894The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.Curr Opin Microbiol2013
23615611Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.Nature2013
23439633The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.Antimicrob Agents Chemother2013
22387043Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.J Struct Biol2012
22866913Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria.Malar J2012
22640832Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.Mol Biochem Parasitol2012
21251930Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.Mol Biochem Parasitol2011
21984828ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.J Biol Chem2011
22004680Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control.Genome Biol2011
21866942A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor.ACS Chem Biol2011
21685321Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.Eukaryot Cell2011
20426475Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum.J Chem Inf Model2010
20686576Branched tricarboxylic acid metabolism in Plasmodium falciparum.Nature2010
20855748Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum.Antimicrob Agents Chemother2010
20674615Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.Mol Biochem Parasitol2010
20644710Highly divergent mitochondrial ATP synthase complexes in Tetrahymena thermophila.PLoS Biol2010
19218089Host-parasite interactions revealed by Plasmodium falciparum metabolomics.Cell Host Microbe2009
19575561Mitochondrial evolution and functions in malaria parasites.Annu Rev Microbiol2009
19320831Complex inheritance of the plasmodial surface anion channel in a Plasmodium falciparum genetic cross.Mol Microbiol2009
18023619The validity of mitochondrial dehydrogenases as antimalarial drug targets.Trends Parasitol2008
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Collaborators

Center for Molecular Parasitology, Drexel University College of Medicine
Co-authored papers 33
The University of Melbourne
Co-authored papers 3
Lewis Sigler Institute for Integrative Genomics, Princeton University
Co-authored papers 3
Center for Biomolecular Science and Engineering, University of California
Co-authored papers 2
US Military Malaria Vaccine Program, Naval Medical Research Center
Co-authored papers 2
Center for Computational Biology, Johns Hopkins University
Co-authored papers 2
Inc., 9800 Medical Center Drive
Co-authored papers 2
The Institute for Genomic Research
Co-authored papers 2
J. Craig Venter Institute
Co-authored papers 2
University of California San Diego
Co-authored papers 2
Clinical Center
Co-authored papers 2
The J. Craig Venter Institute
Co-authored papers 2
Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 2
Center for Computational Biology, Johns Hopkins University
Co-authored papers 2
Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 2
The Institute for Genomic Research, 9712 Medical Center Drive
Co-authored papers 2
Center for Genomics and Systems Biology
Co-authored papers 2
Personal Genome Diagnostics Inc.
Co-authored papers 2
University of Pennsylvania
Co-authored papers 2
Institute for Genome Research
Co-authored papers 2
Craig Venter Institute, 9704 Medical Center Drive
Co-authored papers 2
University of Pennsylvania
Co-authored papers 2
Wellcome Sanger Institute
Co-authored papers 2
Macquarie University
Co-authored papers 1
University of Cambridge
Co-authored papers 1
Julius-Maximilians-Universitat Wurzburg
Co-authored papers 1
University of Oxford
Co-authored papers 1
Harvard T. H. Chan School of Public Health
Co-authored papers 1
University of Dundee
Co-authored papers 1
Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Co-authored papers 1