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Author Details

Elisabetta Manduchi
Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia
1999
62
26
PMIDPaper TitleJournal TitlePublished Year
36503150H3K27me3 Demethylases Maintain the Transcriptional and Epigenomic Landscape of the Intestinal Epithelium.Cell Mol Gastroenterol Hepatol2023
37584517Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors.Cancer Res2023
37037491Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy.Cancer Commun (Lond)2023
36869037Mu-opioid receptor-expressing neurons in the paraventricular thalamus modulate chronic morphine-induced wake alterations.Transl Psychiatry2023
34310318Genetic Analysis of Coronary Artery Disease Using Tree-Based Automated Machine Learning Informed By Biology-Based Feature Selection.IEEE/ACM Trans Comput Biol Bioinform2022
35642629α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals.J Clin Invest2022
35537191Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits.Sleep2022
35654975A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.Nat Genet2022
35986225Predictive value of common genetic variants in idiopathic pulmonary fibrosis survival.J Mol Med (Berl)2022
35883154Benchmarking AutoML frameworks for disease prediction using medical claims.BioData Min2022
34713318The promise of automated machine learning for the genetic analysis of complex traits.Hum Genet2022
34017831Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation.Front Cell Dev Biol2021
33653874A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for <i>Zfp800</i> in pancreas development.Development2021
34744577Leveraging Automated Machine Learning for the Analysis of Global Public Health Data: A Case Study in Malaria.Int J Public Health2021
31583758Embracing study heterogeneity for finding genetic interactions in large-scale research consortia.Genet Epidemiol2020
32027528How Computational Experiments Can Improve Our Understanding of the Genetic Architecture of Common Human Diseases.Artif Life2020
32998684Embedding covariate adjustments in tree-based automated machine learning for biomedical big data analyses.BMC Bioinformatics2020
32620744Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells.Nat Commun2020
32561546Collapse of the hepatic gene regulatory network in the absence of FoxA factors.Genes Dev2020
31145509A comparison of two workflows for regulome and transcriptome-based prioritization of genetic variants associated with myocardial mass.Genet Epidemiol2019
31320928Exploration of a diversity of computational and statistical measures of association for genome-wide genetic studies.BioData Min2019
31234232SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease.Mov Disord2019
30890710Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.Nat Commun2019
29218913Leveraging putative enhancer-promoter interactions to investigate two-way epistasis in Type 2 Diabetes GWAS.Pac Symp Biocomput2018
29797095Leveraging epigenomics and contactomics data to investigate SNP pairs in GWAS.Hum Genet2018
27916240Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress.J Biomech2017
29056226A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.Am J Hum Genet2017
27865480Biofluids, cell mechanics and epigenetics: Flow-induced epigenetic mechanisms of endothelial gene expression.J Biomech2017
27091183Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome.J Am Heart Assoc2016
27851966Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming.Cell Rep2016
27539148The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.Diabetologia2016
27128319The Ontology for Biomedical Investigations.PLoS One2016
25838424Endothelial epigenetics in biomechanical stress: disturbed flow-mediated epigenomic plasticity in vivo and in vitro.Arterioscler Thromb Vasc Biol2015
26148682Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo.BMC Genomics2015
24874278Emerging topic: flow-related epigenetic regulation of endothelial phenotype through DNA methylation.Vascul Pharmacol2014
25053427Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.Development2014
22865702Dual lineage-specific expression of Sox17 during mouse embryogenesis.Stem Cells2012
21266227Discovery approaches to UPR in athero-susceptible endothelium in vivo.Methods Enzymol2011
22190598AnnotCompute: annotation-based exploration and meta-analysis of genomics experiments.Database (Oxford)2011
21493819Coronary artery endothelial transcriptome in vivo: identification of endoplasmic reticulum stress and enhanced reactive oxygen species by gene connectivity network analysis.Circ Cardiovasc Genet2011
20176806Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages.Mol Cell Biol2010
20478996Propagation of adipogenic signals through an epigenomic transition state.Genes Dev2010
20624982MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro.Proc Natl Acad Sci U S A2010
19213738A flexible two-stage procedure for identifying gene sets that are differentially expressed.Bioinformatics2009
19661457Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis.Circ Res2009
19808022LKB1 regulates pancreatic beta cell size, polarity, and function.Cell Metab2009
19098026Matching methods for observational microarray studies.Bioinformatics2009
17185391Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.Mol Endocrinol2007
18265395Analysis and management of microarray gene expression data.Curr Protoc Mol Biol2007
17071715EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes.Nucleic Acids Res2007
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Collaborators

Christian J Stoeckert
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 29
Gregory R Grant
Perelman School of Medicine, University of Pennsylvania Philadelphia
Co-authored papers 14
Jason H Moore
Cedars-Sinai Medical Center
Co-authored papers 13
Struan F A Grant
Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia
Co-authored papers 9
Klaus H Kaestner
Department of Genetics and Institute for Diabetes, University of Pennsylvania
Co-authored papers 9
Andrew D Wells
Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Co-authored papers 8
Alessandra Chesi
Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia
Co-authored papers 7
Matthew E Johnson
Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Co-authored papers 6
Jonathan Schug
University of Pennsylvania Perelman School of Medicine
Co-authored papers 5
Angel Pizarro
The Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Co-authored papers 4
Mete Civelek
Center for Public Health Genomics, University of Virginia
Co-authored papers 4
Sumei Lu
China National Center for Biotechnology Development
Co-authored papers 3
James A Pippin
Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia
Co-authored papers 3
Michelle E Leonard
The Children's Hospital of Philadelphia
Co-authored papers 3
John Brestelli
University of Pennsylvania
Co-authored papers 3
Marshall Alan Permutt
Washington University School of Medicine
Co-authored papers 2
Christopher D Brown
Co-authored papers 2
Patricia L Whetzel
University of Colorado Anschutz Medical Campus
Co-authored papers 2
L M Scearce
University of Pennsylvania
Co-authored papers 2
Jie Zheng
University of Pennsylvania Perelman School of Medicine
Co-authored papers 2
Scott M Williams
Case Western Reserve University School of Medicine
Co-authored papers 2
Joan Mazzarelli
Center for Bioinformatics, University of Pennsylvania
Co-authored papers 2
Jonathan Crabtree
Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 2
Peter White
The Ohio State University
Co-authored papers 2
Deborah F Pinney
University of Pennsylvania
Co-authored papers 2
Joseph H Gorman
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Robert C Gorman
University of Pennsylvania
Co-authored papers 2
Daniel Schober
Institute of Forensic Medicine, University of Bern
Co-authored papers 1
Xiaohui Li
Co-authored papers 1
Braxton D Mitchell
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Release 1.2