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Author Details

Garth Powis
PHusis Therapeutics Inc.
1970
363
79
PMIDPaper TitleJournal TitlePublished Year
37399719Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease.Biomed Pharmacother2023
34800542PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.Exp Cell Res2021
33878292Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.Structure2021
32462959A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A.SLAS Discov2020
31040156An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.Cancer Res2019
31803426Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples.Chem Sci2019
31615811Correction: An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.Cancer Res2019
31585939Absence of HIF1A Leads to Glycogen Accumulation and an Inflammatory Response That Enables Pancreatic Tumor Growth.Cancer Res2019
28820953A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents Targeting Fructose-1,6-Bisphosphate Aldolase.SLAS Discov2018
26983373Clinically Evaluated Cancer Drugs Inhibiting Redox Signaling.Antioxid Redox Signal2017
28468778Modeling of Patient-Derived Xenografts in Colorectal Cancer.Mol Cancer Ther2017
25410163HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer.Gut2016
27806312Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer.Oncotarget2016
27261507Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target.Cancer Res2016
27167191Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models.Oncotarget2016
27187615ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation.Nat Commun2016
26799785A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice.Hepatology2016
26955870Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems.BMC Cancer2016
25421578Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma.Cancer Res2015
26460303Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.J Clin Oncol2015
25449779A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer.Cancer Lett2015
24177031FXR silencing in human colon cancer by DNA methylation and KRAS signaling.Am J Physiol Gastrointest Liver Physiol2014
25344581The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression.Mol Cancer Ther2014
24681952PATHOME: an algorithm for accurately detecting differentially expressed subpathways.Oncogene2014
23251002Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.Clin Cancer Res2013
23859776Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [(131)I] analogue as useful PET tracers for PI3-kinase.Bioorg Med Chem2013
23633488Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer.Cancer Res2013
22247021Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.J Natl Cancer Inst2012
22741038Tumor Xenograft Response to Redox-Active Therapies Assessed by Magnetic Resonance Imaging Using a Thiol-Bearing DOTA Complex of Gadolinium.Transl Oncol2012
22912394The promise of patient-derived xenografts: the best laid plans of mice and men.Clin Cancer Res2012
22818162Passing the baton: the HIF switch.Trends Biochem Sci2012
22434430AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer.Cancer Res2012
22275514Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells.Mol Cancer Res2012
20473884Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma.Int J Cancer2011
21867428Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010.Radiat Res2011
21512133The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.Cancer Res2011
21740251Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities: Report of an NCI Workshop held September 1-3, 2010.Radiat Res2011
21353784Development of sulfonamide AKT PH domain inhibitors.Bioorg Med Chem2011
21364021HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance.Mol Cancer Res2011
21430111Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM.Neuro Oncol2011
21110830Recent development of anticancer therapeutics targeting Akt.Recent Pat Anticancer Drug Discov2011
21069338Antitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase.Cancer Chemother Pharmacol2011
21158718PI-3-Kinase inhibitors in colorectal cancer.Curr Cancer Drug Targets2011
20047145The biological effects of isoform-specific PI3-kinase inhibition.Curr Opin Drug Discov Devel2010
20545760IL-24 is expressed during wound repair and inhibits TGFalpha-induced migration and proliferation of keratinocytes.Exp Dermatol2010
20512076Treatment with HIF-1alpha antagonist PX-478 inhibits progression and spread of orthotopic human small cell lung cancer and lung adenocarcinoma in mice.J Thorac Oncol2010
20587661Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer.Mol Cancer Ther2010
20156803Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma.Neuro Oncol2010
20176047Inhibitors of phosphatidylinositol-3-kinase in cancer therapy.Mol Aspects Med2010
20197390Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.Mol Cancer Ther2010
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Collaborators

University of Texas MD Anderson Cancer Center
Co-authored papers 7
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 6
MD Anderson Cancer Center
Co-authored papers 5
The Institute of Cancer Research
Co-authored papers 4
Stanford University School of Medicine
Co-authored papers 4
University of Texas M.D. Anderson Cancer Center
Co-authored papers 3
The University of Texas MD Anderson Cancer Center
Co-authored papers 3
Mayo Clinic College of Medicine
Co-authored papers 3
Co-authored papers 3
Princess Margaret Cancer Centre
Co-authored papers 3
University of Oxford
Co-authored papers 3
Co-authored papers 3
Yale School of Medicine
Co-authored papers 3
The University of Texas MD Anderson Cancer Center
Co-authored papers 3
Karmanos Cancer Institute (KCI), Wayne State University
Co-authored papers 3
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Moores Cancer Center, university of california san diego
Co-authored papers 2
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
NSABP Foundation
Co-authored papers 2
Co-authored papers 2
Inje University Haeundae Paik Hospital
Co-authored papers 2
University of Toronto
Co-authored papers 2
The University of Sheffield
Co-authored papers 2
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Co-authored papers 2
University of California san francisco
Co-authored papers 2
The Ohio State University Wexner Medical Center
Co-authored papers 2
Knight Cancer Institute, Oregon Health and Sciences University
Co-authored papers 2
Institute of Regeneration and Repair, The University of Edinburgh
Co-authored papers 2
The University of Texas MD Anderson Cancer Center
Co-authored papers 1