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| 27078104 | Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides. | Proc Natl Acad Sci U S A | 2016 |
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| 26470919 | Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. | J Mol Biol | 2015 |
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| 24994900 | Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. | Proc Natl Acad Sci U S A | 2014 |
| 24613931 | Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. | Proc Natl Acad Sci U S A | 2014 |
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| 23707380 | In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities. | J Mol Biol | 2013 |
| 23611499 | Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. | J Am Chem Soc | 2013 |
| 23710599 | Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. | J Med Chem | 2013 |
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| 23075414 | Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. | J Med Chem | 2012 |
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| 21795602 | EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. | Proc Natl Acad Sci U S A | 2011 |
| 21729334 | Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. | BMC Biol | 2011 |
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| 16204883 | The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. | Acta Crystallogr D Biol Crystallogr | 2005 |
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| 14566049 | Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. | Proc Natl Acad Sci U S A | 2003 |
| 12702803 | The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity. | Protein Eng | 2003 |
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| 12033935 | Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. | Biochemistry | 2002 |
| 11697906 | Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases. | J Mol Biol | 2001 |
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| 10653645 | Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance". | Biochemistry | 2000 |
| 10890912 | Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. | Proc Natl Acad Sci U S A | 2000 |
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| 9468142 | Design of potent selective zinc-mediated serine protease inhibitors. | Nature | 1998 |
| 9613841 | The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. | Protein Eng | 1998 |
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