Author details

Full Name

Scott A Lesley

Affiliation

Merck & Co., Inc.

ORCID

Career Start Year

1987

Papers

207

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
35939534	Nanoscale Mapping of EGFR and c-MET Protein Environments on Lung Cancer Cell Surfaces via Therapeutic Antibody Photocatalyst Conjugates.	ACS Chem Biol	2022
32822567	A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.	Cell	2020
31306512	Structures of single-layer Î²-sheet proteins evolved from Î²-hairpin repeats.	Protein Sci	2019
31267450	A High-Throughput System for Transient and Stable Protein Production in Mammalian Cells.	Methods Mol Biol	2019
30284939	Mammalian cell culture density determination using a laser through-beam sensor.	Biotechniques	2018
30072576	Co-regulatory networks of human serum proteins link genetics to disease.	Science	2018
29843542	A Fully Automated High-Throughput Flow Cytometry Screening System Enabling Phenotypic Drug Discovery.	SLAS Discov	2018
27050129	UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex.	Acta Crystallogr D Struct Biol	2016
26650892	Structure and functional characterization of a bile acid 7Î± dehydratase BaiE in secondary bile acid synthesis.	Proteins	2016
26940874	Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome.	J Biol Chem	2016
27062925	A Distinct Type of Pilus from the Human Microbiome.	Cell	2016
25466902	Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice.	FASEB J	2015
26588668	Efficient Preparation of Site-Specific Antibody-Drug Conjugates Using Phosphopantetheinyl Transferases.	Bioconjug Chem	2015
26374125	Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains.	mBio	2015
26177955	Cofactor-induced reversible folding of Flavodoxin-4 from Lactobacillus acidophilus.	Protein Sci	2015
26241692	Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis.	J Chem Inf Model	2015
25826626	Crystal structure of a two-subunit TrkA octameric gating ring assembly.	PLoS One	2015
25825768	Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.	Proc Natl Acad Sci U S A	2015
23836456	Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe.	Proteins	2014
25465128	Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family.	Structure	2014
25286848	Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications.	Acta Crystallogr D Biol Crystallogr	2014
25197798	Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin.	PLoS One	2014
25044324	Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake.	Protein Sci	2014
24888348	Molecular characterization of novel pyridoxal-5'-phosphate-dependent enzymes from the human microbiome.	Protein Sci	2014
24051416	Structures of a bifunctional cell wall hydrolase CwlT containing a novel bacterial lysozyme and an NlpC/P60 DL-endopeptidase.	J Mol Biol	2014
24174223	Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family.	Proteins	2014
23852666	Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site.	Proteins	2014
23572527	Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme.	J Biol Chem	2013
24123814	Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling.	J Bacteriol	2013
22411095	Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.	Proteins	2012
22940582	Identification of unknown protein function using metabolite cocktail screening.	Structure	2012
23019356	Folate binding site of flavin-dependent thymidylate synthase.	Proc Natl Acad Sci U S A	2012
22984442	Structure of a novel winged-helix like domain from human NFRKB protein.	PLoS One	2012
22844465	Structure of an MmyB-like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes.	PLoS One	2012
22467785	The structure of Mlc titration factor A (MtfA/YeeI) reveals a prototypical zinc metallopeptidase related to anthrax lethal factor.	J Bacteriol	2012
22211578	Structure of the pilus assembly protein TadZ from Eubacterium rectale: implications for polar localization.	Mol Microbiol	2012
22295882	Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase.	J Am Chem Soc	2012
21082721	Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima.	Protein Sci	2011
21799766	Structural analysis of papain-like NlpC/P60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites.	PLoS One	2011
21799754	Structural and sequence analysis of imelysin-like proteins implicated in bacterial iron uptake.	PLoS One	2011
21525873	D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine.	Nat Chem Biol	2011
21538547	Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity.	Proteins	2011
21740061	Solubilization of native integral membrane proteins in aqueous buffer by noncovalent chelation with monomethoxy poly(ethylene glycol) (mPEG) polymers.	Bioconjug Chem	2011
21670250	Site-specific protein modifications through pyrroline-carboxy-lysine residues.	Proc Natl Acad Sci U S A	2011
21445265	Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein.	PLoS One	2011
19913036	Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain.	J Mol Biol	2010
20836087	The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu.	Protein Sci	2010
20869368	Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids.	J Mol Biol	2010
20944232	Structure of the Î³-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-Î³-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2010
20944231	Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2010

1 - 50 of 207

Ashwani Kumar

Bhabha Atomic Research Centre

Career Start Year 2009

Number of shared co-authors 0

Lester G Carter

Stanford University

Career Start Year 2004

Number of shared co-authors 13

Elena Evdokimova

University of Toronto

Career Start Year 2002

Number of shared co-authors 15

Yufeng Zhai

ShanghaiTech University

Career Start Year 2000

Number of shared co-authors 4

Sergey M Vorobiev

Columbia University

Career Start Year 1998

Number of shared co-authors 14

Stephen A McMahon

University of St Andrews

Career Start Year 1998

Number of shared co-authors 1

David R Hall

Diamond Light Source Ltd, Harwell Science & Innovation Campus

Career Start Year 1998

Number of shared co-authors 2

Chad A Brautigam

UT Southwestern Medical Center

Career Start Year 1997

Number of shared co-authors 2

Andreas Bracher

Max-Planck-Institute of Biochemistry

Career Start Year 1995

Number of shared co-authors 1

Clemens Vonrhein

Global Phasing Ltd

Career Start Year 1995

Number of shared co-authors 2

Diana R Tomchick

University of Texas Southwestern Medical Center

Career Start Year 1993

Number of shared co-authors 3

Constance J Jeffery

University of Illinois at Chicago

Career Start Year 1993

Number of shared co-authors 0

Michael A Kennedy

Miami University

Career Start Year 1993

Number of shared co-authors 23

Stephen Matthews

Imperial College London

Career Start Year 1993

Number of shared co-authors 3

Gyorgy Babnigg

Argonne National Laboratory

Career Start Year 1992

Number of shared co-authors 8

Subbiah Parthasarathy

New York University Grossman School of Medicine

Career Start Year 1990

Number of shared co-authors 14

Karen N Allen

Boston University

Career Start Year 1989

Number of shared co-authors 5

Donald D Lorimer

Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Career Start Year 1986

Number of shared co-authors 12

Tomohiro Tamura

National Institute of Advanced Industrial Science and Technology (AIST)

Career Start Year 1985

Number of shared co-authors 1

Vladimir N Malashkevich

Albert Einstein College of Medicine

Career Start Year 1982

Number of shared co-authors 9

Alan R Davidson

University of Toronto, University Avenue

Career Start Year 1980

Number of shared co-authors 5

Enrique Querol

Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona

Career Start Year 1980

Number of shared co-authors 2

Hans J Vogel

University of Calgary

Career Start Year 1979

Number of shared co-authors 2

Tom Alber

University of California berkeley

Career Start Year 1976

Number of shared co-authors 7

Ivan Rayment

College of Agricultural and Life Sciences, University of Wisconsin-Madison

Career Start Year 1976

Number of shared co-authors 1

Ezra Peisach

The State University of New Jersey

Career Start Year 1975

Number of shared co-authors 2

George N Phillips

Rice University

Career Start Year 1974

Number of shared co-authors 9

Wayne A Hendrickson

Columbia University

Career Start Year 1968

Number of shared co-authors 11

Robert M Stroud

University of California San Francisco

Career Start Year 1965

Number of shared co-authors 6

David Eisenberg

university of california los angeles

Career Start Year 1963

Number of shared co-authors 11

row(s) 1 - 30 of 30

Ian A Wilson

The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology

Co-authored papers 131

Ashley M Deacon

Accelero Biostructures Inc., USA XPose Therapeutics Inc.

Co-authored papers 124

Heath E Klock

Merck & Co., Inc.

Co-authored papers 122

Marc-Andr?? Elsliger

Joint Center for Structural Genomics

Co-authored papers 121

Adam Godzik

University of California Riverside

Co-authored papers 121

Mitchell D Miller

Rice University

Co-authored papers 111

Lukasz Jaroszewski

University of California Riverside School of Medicine

Co-authored papers 110

Hsiu-Ju Chiu

Joint Center for Structural Genomics

Co-authored papers 98

Qingping Xu

Argonne National Laboratory

Co-authored papers 97

Daniel McMullan

Genomics Institute of the Novartis Research Foundation

Co-authored papers 95

John Wooley

University of California

Co-authored papers 93

Keith O Hodgson

Stanford University

Co-authored papers 90

Henry van den Bedem

University of California San Francisco

Co-authored papers 89

Andrew T Morse

Co-authored papers 78

Polat Abdubek

Regeneron Pharmaceuticals, Inc.

Co-authored papers 74

Mark W Knuth

Joint Center for Structural Genomics

Co-authored papers 72

Slawomir K Grzechnik

Co-authored papers 72

Ron Reyes

Co-authored papers 67

Edward Nigoghossian

Genomics Institute of the Novartis Research Foundation

Co-authored papers 63

Gye Won Han

Bridge Institute, University of Southern California

Co-authored papers 60

Herbert L Axelrod

Joint Center for Structural Genomics

Co-authored papers 59

Sanjay Krishna

Institute of Science, Banaras Hindu University

Co-authored papers 52

Peter Kuhn

University of Tubingen

Co-authored papers 51

Raymond C Stevens

iHuman Institute, ShanghaiTech University

Co-authored papers 51

Christopher L Rife

The Joint Center for Structural Genomics, Stanford University

Co-authored papers 50

Linda Okach

Co-authored papers 47

Julie Feuerhelm

Co-authored papers 47

Kevin K Jin

Cardiovascular Institute, Stanford University School of Medicine

Co-authored papers 47

Thomas Clayton

Celgene/Bristol-Myers Squibb Corporation

Co-authored papers 46

Lian Duan

Brown University

Co-authored papers 46

1 - 30

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