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Author Details

Nikola P Pavletich
Memorial Sloan Kettering Cancer Center
1991
83
66
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35076389Structure of the human ATM kinase and mechanism of Nbs1 binding.Elife2022
34592688Insights into homology search from cryo-EM structures of RecA-DNA recombination intermediates.Curr Opin Genet Dev2021
33686268Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.Nat Struct Mol Biol2021
32269332DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex.Nature2020
33057191Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures.Nature2020
31577956A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.Cell Rep2019
29236692Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.Nature2017
27006647N-Terminal Amino Acid Sequence Determination of Proteins by N-Terminal Dimethyl Labeling: Pitfalls and Advantages When Compared with Edman Degradation Sequence Analysis.J Biomol Tech2016
26328598Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent.J Med Chem2015
26491943Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.Elife2015
25430771DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.Science2014
23636326mTOR kinase structure, mechanism and regulation.Nature2013
23070815Structure and conformational change of a replication protein A heterotrimer bound to ssDNA.Genes Dev2012
21764741Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway.Science2011
20801936Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.Genes Dev2010
19782031Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.Mol Cell2009
18497818Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.Nature2008
19109893Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.Cell2008
17218261Ubiquitination regulates PTEN nuclear import and tumor suppression.Cell2007
17882165Recognition of DNA damage by the Rad4 nucleotide excision repair protein.Nature2007
17434132Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.Mol Cell2007
17170710The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.EMBO J2007
15806108Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54.Nat Struct Mol Biol2005
16209941Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.Mol Cell2005
16275325High-level expression and purification of recombinant SCF ubiquitin ligases.Methods Enzymol2005
16360038Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.Cell2005
15703751The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction.Nature2005
15027863N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.J Med Chem2004
15242600Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.Structure2004
12820959Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.Mol Cell2003
12962634Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways.Structure2003
14534320Werner syndrome protein contains three structure-specific DNA binding domains.J Biol Chem2003
14580353The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis.Mol Cell2003
12686552Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding.J Biol Chem2003
11877378Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.Genes Dev2002
16033158Structural biology of ubiquitin-protein ligases.Harvey Lect2002
12190313Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.J Med Chem2002
12228710BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.Science2002
12467573Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.Structure2002
11961546Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.Nature2002
12004076Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.Science2002
12121644Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.Structure2002
11029468Kinetic basis for activation of CDK2/cyclin A by phosphorylation.J Biol Chem2001
11226270Role of the F-box protein Skp2 in lymphomagenesis.Proc Natl Acad Sci U S A2001
11427894Structure of the histone deacetylase SIRT2.Nat Struct Biol2001
11156408Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.Cancer Res2000
10860994Identification and characterization of a p53 homologue in Drosophila melanogaster.Proc Natl Acad Sci U S A2000
10878807Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein.Nat Cell Biol2000
10966114Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.Cell2000
11099048Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.Nature2000
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Collaborators

University of Washington
Co-authored papers 7
Harvard Medical School
Co-authored papers 4
Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 4
Simons Center for Systems Biology, Institute for Advanced Study
Co-authored papers 3
Neuroscience Institute, NYU Grossman School of Medicine
Co-authored papers 3
Memorial Sloan-Kettering Cancer Center
Co-authored papers 3
Instituto de Investigacion Sanitaria Hospital 12 de Octubre (imas12)
Co-authored papers 2
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
MRC - University of Glasgow Centre for Virus Research, University of Glasgow
Co-authored papers 2
Cardiovascular Research Institute, University of California san francisco
Co-authored papers 2
University of California san francisco
Co-authored papers 2
Co-authored papers 2
Indiana University School of Medicine
Co-authored papers 2
Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 1
Memorial Sloan-Kettering Cancer Center
Co-authored papers 1
Co-authored papers 1
Herbert Irving Comprehensive Cancer Center, Columbia University
Co-authored papers 1
Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
Co-authored papers 1
Joint Center for Structural Genomics
Co-authored papers 1
Memorial Sloan Kettering Cancer Center
Co-authored papers 1
Co-authored papers 1
Broad Institute of MIT and Harvard
Co-authored papers 1
Co-authored papers 1
University of California Irvine
Co-authored papers 1
Rockefeller University
Co-authored papers 1
Discovery and Preclinical Sciences
Co-authored papers 1
Robert Wood Johnson Medical School
Co-authored papers 1
The Rockefeller University
Co-authored papers 1
Memorial Sloan Kettering Cancer Center
Co-authored papers 1
Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
Co-authored papers 1