Author details

Full Name

Erik J Sontheimer

Affiliation

ORCID

Career Start Year

1992

Papers

109

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37889041	CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes.	Nucleic Acids Res	2024
38033325	Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.	Nucleic Acids Res	2024
37291100	Template-jumping prime editing enables large insertion and exon rewriting in vivo.		2023
35932276	Multiomics characterization of mouse hepatoblastoma identifies yes-associated protein 1 target genes.	Hepatology	2023
37853195	Viruses use RNA decoys to thwart CRISPR defences.		2023
37904991	Addressing the dNTP bottleneck restricting prime editing activity.		2023
37794046	PAM-flexible genome editing with an engineered chimeric Cas9.	Nat Commun	2023
37709915	Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates.		2023
37961518	Modular vector assembly enables rapid assessment of emerging CRISPR technologies.		2023
37156841	Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.		2023
37131611	Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope.		2023
36945419	PAM-Flexible Genome Editing with an Engineered Chimeric Cas9.	Res Sq	2023
36993169	Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing <i>in vivo</i>.	bioRxiv	2023
37100169	Applications of Anti-CRISPR Proteins in Genome Editing and Biotechnology.		2023
34735006	Orthogonal CRISPR-Cas tools for genome editing, inhibition, and CRISPR recording in zebrafish embryos.	Genetics	2022
35446558	Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing.	ACS Chemical Biology	2022
35379962	A split prime editor with untethered reverse transcriptase and circular RNA template.	Nature Biotechnology	2022
35811581	Adenine Base Editing with a Single Adeno-Associated Virus Vector.		2022
36271076	CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.	Nat Commun	2022
36070530	Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors.	CRISPR Journal	2022
35920332	Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.	Nucleic Acids Res	2022
35064134	Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.	Nat Commun	2022
34836963	CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease.	Nature Communications	2021
32452550	YAP1 Withdrawal in Hepatoblastoma Drives Therapeutic Differentiation of Tumor Cells to Functional Hepatocyte-Like Cells.	Hepatology	2021
33837189	Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.	Nature Communications	2021
33828315	The NIH Somatic Cell Genome Editing program.	Nature	2021
34725353	Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo.	Nature Communications	2021
34665130	5'-Modifications improve potency and efficacy of DNA donors for precision genome editing.	eLife	2021
32561876	Publisher Correction: An engineered ScCas9 with broad PAM range and high specificity and activity.	Nature Biotechnology	2020
32142691	CRISPR Shields: Fending Off Diverse Cas Nucleases with Nucleus-like Structures.	Mol Cell	2020
32424114	A Cas9 with PAM recognition for adenine dinucleotides.	Nature Communications	2020
32186918	Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems.	Annu Rev Biochem	2020
32393822	An engineered ScCas9 with broad PAM range and high specificity and activity.	Nature Biotechnology	2020
32631881	Shutting down RNA-targeting CRISPR.	Science	2020
31243272	Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.	Nat Commun	2019
31722192	Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing.	Cell Rep	2019
31668930	Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.	Molecular Cell	2019
30581144	A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for InÂ Vivo Genome Editing.	Molecular Cell	2019
31225753	X-Tracting a New CRISPR-Cas Genome-Editing Platform from Metagenomic Data Sets.	CRISPR Journal	2019
30691651	Adapting dCas9-APEX2 for subnuclear proteomic profiling.	Methods in Enzymology	2019
29779790	A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein.	Structure	2018
30514786	Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.	mBio	2018
29980686	Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing.	Nat Commun	2018
30451839	Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing.	Nature Communications	2018
30531933	Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing.	Nature Communications	2018
30231914	All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo.		2018
30518407	NmeCas9 is an intrinsically high-fidelity genome-editing platform.		2018
29463924	CRISPRs from scratch.	Nature Microbiology	2018
29202216	Type II-C CRISPR-Cas9 Biology, Mechanism, and Application.	ACS Chemical Biology	2018
29735996	C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2.	Nat Methods	2018