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Author Details

Jan Rehwinkel
MRC Weatherall Institute of Molecular Medicine, University of Oxford
2004
85
45
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36863752Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider.RMD Open2023
37450010The Z-nucleic acid sensor ZBP1 in health and disease.J Exp Med2023
368588212022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice.Ann Rheum Dis2023
36882218Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider.RMD Open2023
36442623A simple transwell-based infection system for obtaining pure populations of VZV-infected cells.J Virol Methods2023
35291294Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.bioRxiv2022
35475759The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses.Elife2022
36241425Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.Life Sci Alliance2022
36268590Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.EMBO Rep2022
34253898Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.Nat Cell Biol2021
33746960Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype.Front Immunol2021
34525337Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.Immunity2021
34611323Publisher Correction: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration.Nat Cell Biol2021
34686311Interferon induction held captive in tumor cells.Mol Cell2021
34211037The RNA sensor MDA5 detects SARS-CoV-2 infection.Sci Rep2021
34234126Fractional response analysis reveals logarithmic cytokine responses in cellular populations.Nat Commun2021
34142428Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.EMBO Rep2021
31608988Deoxyguanosine is a TLR7 agonist.Eur J Immunol2020
34192267Innate immunology in COVID-19-a living review. Part I: viral entry, sensing and evasion.Oxf Open Immunol2020
31786265Nucleic Acid Sensors and Programmed Cell Death.J Mol Biol2020
33115807Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types.Cancer Res2020
33087717Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.Nat Commun2020
33155371Regulation and inhibition of the DNA sensor cGAS.EMBO Rep2020
33235905PNP inhibitors selectively kill cancer cells lacking SAMHD1.Mol Cell Oncol2020
33230297cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing.Nat Genet2020
32725128Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.J Exp Med2020
33009401SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.Nat Commun2020
32205315Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells.Cancer Immunol Res2020
32203325RIG-I-like receptors: their regulation and roles in RNA sensing.Nat Rev Immunol2020
32560274RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death.Cells2020
32541831Redox homeostasis maintained by GPX4 facilitates STING activation.Nat Immunol2020
32402273SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.Cell Rep2020
32511795SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.EMBO J2020
32315377Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.J Exp Med2020
30510168Antiviral activity of bone morphogenetic proteins and activins.Nat Microbiol2019
30201512A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation.Trends Microbiol2019
30918010A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis.Life Sci Alliance2019
31076606PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection.Sci Rep2019
29161093B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis.Am J Respir Crit Care Med2018
30046113Mitochondrial double-stranded RNA triggers antiviral signalling in humans.Nature2018
30061387Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.Proc Natl Acad Sci U S A2018
29572905Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.Eur J Immunol2018
28759028Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.Nat Cell Biol2017
28279982A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.Genes Dev2017
28329697RECONsidering Sensing of Cyclic Dinucleotides.Immunity2017
28122869A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.EMBO J2017
29168145Erratum to: Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.Methods Mol Biol2017
28808967Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.Methods Mol Biol2017
28716805Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.EMBO J2017
27477283Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.Cell Rep2016
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Collaborators

Peer Bork
University of Wurzburg
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Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
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University of Oxford
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Max Planck Institute of Immunobiology and Epigenetics
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University College London
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University of California San Francisco
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Jeroen Raes
KU Leuven - University of Leuven
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Jack Ng Marshall
Sheffield Institute for Translational Neuroscience, University of Sheffield
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Andrew Peden
University of Sheffield
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Michael P Snyder
Stanford University School of Medicine
Co-authored papers 1
David E Gordon
Emory University
Co-authored papers 1
Calum Harvey
Sheffield Institute for Translational Neuroscience, University of Sheffield
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John Franklin
Sheffield Institute for Translational Neuroscience, University of Sheffield
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Lars Zender
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Eleni Giannoulatou
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Michael Boutros
German Cancer Research Center (DKFZ) and Heidelberg University
Co-authored papers 1
Steven E Brenner
University of California berkeley
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Robertus A M de Bruin
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