Author details

Full Name

Diana Carvalho

Affiliation

ORCID

Career Start Year

2010

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37001527	Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities.	Cancer Cell	2023
35105861	PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.	Nat Commun	2022
34737188	DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition.	Cancer Discovery	2022
34551970	Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma.	Cancer Discov	2022
34003511	Pathogenic ACVR1<sup>R206H</sup> activation by Activin A-induced receptor clustering and autophosphorylation.	EMBO J	2021
34169282	Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients.	Neurooncol Adv	2021
32238360	Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.	Cancer Discov	2020
31098401	ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.	Commun Biol	2019
30446898	International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma.	J Neurooncol	2019
30484110	Correction to: International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma.	J Neurooncol	2019
31439867	PPM1D mutations silence NAPRT geneÂ expression and confer NAMPT inhibitor sensitivity in glioma.	Nat Commun	2019
29348602	The ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion.	Scientific Reports	2018
29967352	Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells.	Nat Med	2018
30085668	Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept.	Journal of Medicinal Chemistry	2018
28966033	Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.	Cancer Cell	2017
26919435	New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.	Cell	2016
24705252	Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma.	Nat Genet	2014
24548782	The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma.	Acta neuropathologica communications	2014
23539269	Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.	Cancer Discov	2013
23970477	Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas.	Cancer Res	2013
22389665	Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.	PLoS One	2012
20570930	A distinct spectrum of copy number aberrations in pediatric high-grade gliomas.	Clin Cancer Res	2010