Author details

Full Name

Frank J Gonzalez

Affiliation

ORCID

Career Start Year

1978

Papers

1257

H Index

172

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37035999	Implicit-explicit discrepancies regarding racial attitudes among U.S. Whites.		2023
35655096	Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity.	Acta Pharmacologica Sinica	2023
35460276	Intestinal peroxisome proliferator-activated receptor Î±-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis.	Hepatology	2023
36152789	Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule.	Journal of Steroid Biochemistry and Molecular Biology	2023
37738906	Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii.		2023
37626746	Oleuropein Promotes Neural Plasticity and Neuroprotection via PPARÎ±-Dependent and Independent Pathways.		2023
37623879	Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-Î± Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Transgenic Mice.		2023
37556879	Withdrawal: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.		2023
36779417	PPARÎ± activation partially drives NAFLD development in liver-specific Hnf4a-null mice.		2023
37151873	Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence.		2023
37334379	The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11.		2023
37398234	Changes in the Type 2 diabetes gut mycobiome associate with metformin treatment across populations.		2023
36765047	Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer.		2023
37328648	Cardiomyocyte peroxisome proliferator-activated receptor Î± prevents septic cardiomyopathy via improving mitochondrial function.		2023
36880546	Racial and ethnic variation in the negativity bias-ideology connection: .		2023
37326825	AKAP12 promotes cancer stem cell-like phenotypes and activates STAT3 in colorectal cancer.		2023
37005411	Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice.		2023
36626642	Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines.		2023
37239961	Hepatocyte Nuclear Factor 4Î± (HNF4Î±) Plays a Controlling Role in Expression of the Retinoic Acid Receptor Î² () Gene in Hepatocytes.		2023
36796223	Keratin 79 is a PPARA target that is highly expressed by liver damage.	Biochem Biophys Res Commun	2023
36926457	Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs.	ACS Pharmacol Transl Sci	2023
36789439	Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response.	bioRxiv	2023
37535747	Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.	Science	2023
37515840	Farnesoid X receptor activation inhibits pancreatic carcinogenesis.		2023
37219858	Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice.		2023
34995708	Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis.	Food and Chemical Toxicology	2022
35454993	Epigenome-Wide Analysis of DNA Methylation in Parkinson's Disease Cortex.	Life (Basel)	2022
35838048	Creatine riboside is a cancer cell-derived metabolite associated with arginine auxotrophy.	J Clin Invest	2022
35646522	Crosstalk between CYP2E1 and PPAR substrates and agonists modulate adipose browning and obesity.	Acta Pharmaceutica Sinica B	2022
35443180	HNF4A modulates glucocorticoid action in the liver.	Cell Rep	2022
36288692	Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting.	Cell Reports	2022
36209823	The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice.	J Biol Chem	2022
36207498	Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer.	npj Precision Oncology	2022
35991901	Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens.	Frontiers in Pharmacology	2022
35866568	Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice.	Hepatology Communications	2022
35414769	Disruption of peroxisome proliferator-activated receptor Î± in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway.	International Journal of Biological Sciences	2022
36261549	Gut bacteria alleviate smoking-related NASH by degrading gut nicotine.	Nature	2022
36196594	Glycine-Î²-muricholic acid antagonizes the intestinal farnesoid X receptor-ceramide axis and ameliorates NASH in mice.	Hepatology Communications	2022
35857504	Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.	Science advances	2022
36055192	Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal.		2022
35917881	Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in mouse liver.	Mol Cell Endocrinol	2022
36435799	Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins.	Nature Communications	2022
34870866	Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity.	Hepatology	2022
35283114	Postprandial Plasma Lipidomics Reveal Specific Alteration of Hepatic-derived Diacylglycerols in Nonalcoholic Fatty Liver Disease.	Gastroenterology	2022
34861291	The role of mouse and human peroxisome proliferator-activated receptor-Î± in modulating the hepatic effects of perfluorooctane sulfonate in mice.	Toxicology	2022
35271802	Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis.		2022
34615341	Critical role of peroxisome proliferator-activated receptor Î± in promoting platelet hyperreactivity and thrombosis under hyperlipidemia.	Haematologica	2022
34387904	YAP-TEAD mediates PPAR Î±-induced hepatomegaly and liver regeneration in mice.	Hepatology	2022
34376812	Cardiomyocyte peroxisome proliferator-activated receptor Î± is essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling.	Acta Pharmacologica Sinica	2022
34420370	6Î²-Hydroxytestosterone Promotes Angiotensin II-Induced Hypertension via Enhanced Cytosolic Phospholipase A<sub>2</sub>Î± Activity.	Hypertension	2021